Search Results - "Blakely, R.D."

Natural and engineered coding variation in antidepressant-sensitive serotonin transporters by Ye, R, Blakely, R.D

“…Abstract The presynaptic serotonin (5-HT) transporter (SERT) is a key regulator of 5-HT signaling and is a major target for antidepressant medications and…”
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Cocaine modulates mammalian circadian clock timing by decreasing serotonin transport in the SCN by Prosser, R.A, Stowie, A, Amicarelli, M, Nackenoff, A.G, Blakely, R.D, Glass, J.D

“…Highlights • Cocaine in the day and night alters circadian clock phase regulation in vivo and in vitro. • Pharmacological experiments suggest that this…”
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Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75 by Hoard, J.L, Hoover, D.B, Mabe, A.M, Blakely, R.D, Feng, N, Paolocci, N

“…Abstract Half of the cholinergic neurons of human and primate intrinsic cardiac ganglia (ICG) have a dual cholinergic/noradrenergic phenotype. Likewise, a…”
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Motor neuron-specific overexpression of the presynaptic choline transporter: impact on motor endurance and evoked muscle activity by Lund, D, Ruggiero, A.M, Ferguson, S.M, Wright, J, English, B.A, Reisz, P.A, Whitaker, S.M, Peltier, A.C, Blakely, R.D

“…Abstract The presynaptic, hemicholinium-3 sensitive, high-affinity choline transporter (CHT) supplies choline for acetylcholine (ACh) synthesis. In mice, a…”
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Novel fluorescence-based approaches for the study of biogenic amine transporter localization, activity, and regulation by Mason, J.N., Farmer, H., Tomlinson, I.D., Schwartz, J.W., Savchenko, V., DeFelice, L.J., Rosenthal, S.J., Blakely, R.D.

“…Pre-synaptic norepinephrine (NE) and dopamine (DA) transporters (NET and DAT) terminate catecholamine synaptic transmission through reuptake of released…”
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Drosophila Serotonin Transporters Have Voltage-Dependent Uptake Coupled to a Serotonin-Gated Ion Channel by Galli, A, Petersen, C.I, deBlaquiere, M, Blakely, R.D, DeFelice, L.J

“…Serotonin (5HT) transporters (SERTs) couple to existing ion gradients to transport 5HT into presynaptic terminals. In mammalian SERTs, the transport cycle is…”
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Developmental expression of the high affinity choline transporter in cholinergic sympathetic neurons by Guidry, G., Willison, B.D., Blakely, R.D., Landis, S.C., Habecker, B.A.

“…Choline uptake by the high affinity choline transporter (CHT) is the rate-limiting step in acetylcholine synthesis. Induction of CHT is therefore a critical…”
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Regulation of the human serotonin transporter. Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding by Ramamoorthy, S, Cool, D R, Mahesh, V B, Leibach, F H, Melikian, H E, Blakely, R D, Ganapathy, V

“…Treatment of confluent cultures of JAR human placental choriocarcinoma cells with cholera toxin or forskolin for 16 h markedly stimulated (2.4-fold) serotonin…”
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Human norepinephrine transporter. Biosynthetic studies using a site-directed polyclonal antibody by MELIKIAN, H. E, MCDONALD, J. K, GU, H, RUDNICK, G, MOORE, K. R, BLAKELY, R. D

“…Antibodies have been raised against synthetic peptides derived from the predicted primary sequence of the human cocaine- and antidepressant-sensitive…”
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Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity by Ellegood, J, Anagnostou, E, Babineau, B A, Crawley, J N, Lin, L, Genestine, M, DiCicco-Bloom, E, Lai, J K Y, Foster, J A, Peñagarikano, O, Geschwind, D H, Pacey, L K, Hampson, D R, Laliberté, C L, Mills, A A, Tam, E, Osborne, L R, Kouser, M, Espinosa-Becerra, F, Xuan, Z, Powell, C M, Raznahan, A, Robins, D M, Nakai, N, Nakatani, J, Takumi, T, van Eede, M C, Kerr, T M, Muller, C, Blakely, R D, Veenstra-VanderWeele, J, Henkelman, R M, Lerch, J P

“…Autism is a heritable disorder, with over 250 associated genes identified to date, yet no single gene accounts for >1–2% of cases. The clinical presentation,…”
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Do neuroinflammatory pathways contribute to serotoninergic alterations in autism? p38alpha MAPK signaling drives perturbed serotonin clearance, receptor hypersensitivity, and social behavior deficits in the SERT Ala56 mouse by Robson, M.J., Quinlan, M.A., Veenstra-VanderWeele, J., Watterson, D.M., Blakely, R.D.

“…Autism Spectrum Disorder (ASD) is a prevalent neurodevelopmental disorder with no FDA approved medications that alleviate core symptoms. Aberrant…”
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Linkage and association analysis at the serotonin transporter (SLC6A4) locus in a rigid-compulsive subset of autism by McCauley, J.L., Olson, L.M., Dowd, M., Amin, T., Steele, A., Blakely, R.D., Folstein, S.E., Haines, J.L., Sutcliffe, J.S.

“…Autism is a complex genetic neurodevelopmental disorder in which affected individuals display deficits in language, social relationships, and patterns of…”
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Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders by HAHN, M. K, BLAKELY, R. D

“…The norepinephrine, dopamine and serotonin transporters (NET, DAT and SERT, respectively), limit cellular signaling by recapturing released neurotransmitter,…”
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Norepinephrine transporter-deficient mice respond to anxiety producing and fearful environments with bradycardia and hypotension by Keller, N.R., Diedrich, A., Appalsamy, M., Miller, L.C., Caron, M.G., McDonald, M.P., Shelton, R.C., Blakely, R.D., Robertson, D.

“…The study of anxiety and fear involves complex interrelationships between psychiatry and the autonomic nervous system. Altered noradrenergic signaling is…”
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C. elegans: a novel pharmacogenetic model to study Parkinson's disease by Nass, R., Miller, D.M., Blakely, R.D.

“…Parkinson's disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta. Although the use of vertebrate and…”
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Pore models for transporters? by DeFelice, L.J., Blakely, R.D.

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Cloning, expression, and localization of a chloride-facilitated, cocaine-sensitive serotonin transporter from Drosophila melanogaster by Demchyshyn, L.L, Pristupa, Z.B, Sugamori, K.S, Barker, E.L, Blakely, R.D, Wolfgang, W.J, Forte, M.A, Niznik, H.B

“…We report here on the isolation and characterization of a serotonin (5HT) transporter from Drosophila melanogaster. A 3.1-kb complementary DNA done (dSERT) was…”
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Autocrine Regulation of Norepinephrine Transporter Expression by Ren, Z.G., Pörzgen, P., Zhang, J.M., Chen, X.R., Amara, S.G., Blakely, R.D., Sieber-Blum, M.

“…Thenorepinephrine transporter (NET) is a neurotransmitter scavenger and site of drug action in noradrenergic neurons. The aim of this study was to identify…”
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