Search Results - "Blakeley, D"

Simulating the influence of plasma protein on measured receptor affinity in biochemical assays reveals the utility of Schild analysis for estimating compound affinity for plasma proteins by Blakeley, D, Sykes, D A, Ensor, P, Bertran, E, Aston, P J, Charlton, S J

“…Background and Purpose Plasma protein binding (PPB) influences the free fraction of drug available to bind to its target and is therefore an important…”
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Impacts of landscape structure on butterfly range expansion by Hill, J.K., Collingham, Y.C., Thomas, C.D., Blakeley, D.S., Fox, R., Moss, D., Huntley, B.

“…Since the 1940s, the distributions of several butterfly species have been expanding in northern Europe, probably in response to climate warming. We focus on…”
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Design and characterization of a high affinity and selective bicyclic peptide binder to MT1-MMP for development of a treatment for solid tumours by Harrison, H, Chen, L, Teufel, D, Van Rietschoten, K, Campbell, S, Brown, A, Blakeley, D, Bennett, G, Langford, G, Bonny, C

“…A proprietary phage display and cyclic peptide technology (Bicycle... technology) was utilized to identify high-affinity binding peptides to membrane type…”
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Evolution of flight morphology in a butterfly that has recently expanded its geographic range by Hill, J.K, Thomas, C.D, Blakeley, D.S

“…Individuals colonizing unoccupied habitats typically possess characters associated with increased dispersal and, in insects, colonization success has been…”
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Noninvasive carotid artery testing : a meta-analytic review by BLAKELEY, D. D, ODDONE, E. Z, HASSELBLAD, V, SIMEL, D. L, MATCHAR, D. B

“…To compare the operating characteristics of six noninvasive tests for carotid artery stenosis. A structured search was done using MEDLINE, reference lists from…”
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A Genetically Inactivated Herpes Simplex Virus Type 2 (HSV-2) Vaccine Provides Effective Protection against Primary and Recurrent HSV-2 Disease by Boursnell, M. E. G., Entwisle, C., Blakeley, D., Roberts, C., Duncan, I. A., Chisholm, S. E., Martin, G. M., Jennings, R., Ní Challanaín, D., Sobek, I., Inglis, S. C., McLean, C. S.

“…A glycoprotein H (gH)-deleted herpes simplex virus type 2 (HSV-2) was evaluated as a vaccine for the prevention of HSV-induced disease. This virus, which we…”
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Geometric frustration in the myosin superlattice of vertebrate muscle by Millane, Rick P, Wojtas, David H, Hong Yoon, Chun, Blakeley, Nicholas D, Bones, Philip J, Goyal, Abhishek, Squire, John M, Luther, Pradeep K

“…Geometric frustration results from an incompatibility between minimum energy arrangements and the geometry of a system, and gives rise to interesting and novel…”
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Split-superpositive GFP reassembly is a fast, efficient, and robust method for detecting protein-protein interactions in vivo by Blakeley, Brett D, Chapman, Alex M, McNaughton, Brian R

“…Split-GFP reassembly is an operationally simple in vivo technique used to identify and study interactions involving proteins and/or peptides. However, the…”
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Synthetic RNA Recognition Motifs That Selectively Recognize HIV‑1 Trans-Activation Response Element Hairpin RNA by Blakeley, Brett D, McNaughton, Brian R

“…A multitude of RNA hairpins are directly implicated in human disease. Many of these RNAs are potentially valuable targets for drug discovery and basic…”
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Methods for identifying and characterizing interactions involving RNA by Blakeley, Brett D., DePorter, Sandra M., Mohan, Utpal, Burai, Ritwik, Tolbert, Blanton S., McNaughton, Brian R.

“…[Display omitted]…”
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An Evolved RNA Recognition Motif That Suppresses HIV‑1 Tat/TAR-Dependent Transcription by Crawford, David W, Blakeley, Brett D, Chen, Po-Han, Sherpa, Chringma, Le Grice, Stuart F.J, Laird-Offringa, Ite A, McNaughton, Brian R

“…Potent and selective recognition and modulation of disease-relevant RNAs remain a daunting challenge. We previously examined the utility of the U1A N-terminal…”
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Preclinical evaluation of whole cell vaccines for prophylaxis and therapy using a disabled infectious single cycle-herpes simplex virus vector to transduce cytokine genes by ALI, S. A, MCLEAN, C. S, VILE, R, ROBINS, R. A, REES, R. C, BOURSNELL, M. E. G, MARTIN, G, HOLMES, C. L, REEDER, S, ENTWISLE, C, BLAKELEY, D. M, SHIELDS, J. G, TODRYK, S

“…The development of genetically modified "whole" tumor cell vaccines for cancer therapy relies on the efficient transduction and expression of genes by vectors…”
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Transit Peptides Play a Major Role in the Preferential Import of Proteins into Leucoplasts and Chloroplasts by Wan, Jiangxin, Blakeley, Stephen D., Dennis, David T., Ko, Kenton

“…The in vitro import characteristics of six different precursors of plastid proteins were assessed to determine differences in the protein import pathways of…”
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Analysis of Protein–RNA Complexes Involving a RNA Recognition Motif Engineered To Bind Hairpins with Seven- and Eight-Nucleotide Loops by Blakeley, Brett D, Shattuck, Jenifer, Coates, Melissa B, Tran, Evelyn, Laird-Offringa, Ite A, McNaughton, Brian R

“…U1A binds U1hpII, a hairpin RNA with a 10-nucleotide loop. A U1A mutant (ΔK50ΔM51) binds U1hpII-derived hairpins with shorter loops, making it an interesting…”
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Normal growth of transgenic tobacco plants in the absence of cytosolic pyruvate kinase by Gottlob-McHugh, S.G, Sangwan, R.S, Blakeley, S.D, Vanlerberghe, G.C, Ko, K, Turpin, D.H, Plaxton, W.C, Miki, B.L, Dennis, D.T

“…The coding sequence of the cytosolic isozyme of Potato tuber pyruvate kinase (PK) was attached to the transit peptide of the small subunit of pea…”
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Effects of bombesin and insulin on inositol (1,4,5)trisphosphate and inositol (1,3,4)trisphosphate formation in Swiss 3T3 cells by Heslop, J P, Blakeley, D M, Brown, K D, Irvine, R F, Berridge, M J

“…The effects of bombesin and insulin, separately and in combination, have been studied in Swiss mouse 3T3 cells. Bombesin caused a rapid transfer of 3H from the…”
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Effect of freeze temperature on ice formation and long-term survival of the woolly bear caterpillar ( Pyrrharctia isabella) by Layne, Jack R, Blakeley, Deborah L

“…Tissue ice content and post-freeze survival were documented for caterpillars of the arctiid moth Pyrrharctia isabella. Tissue ice content was inversely…”
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Protein kinase C-mediated negative-feedback inhibition of unstimulated and bombesin-stimulated polyphosphoinositide hydrolysis in Swiss-mouse 3T3 cells by Brown, K D, Blakeley, D M, Hamon, M H, Laurie, M S, Corps, A N

“…Bombesin-related peptides stimulate a rapid increase in polyphosphoinositide hydrolysis in Swiss-mouse 3T3 cells. These peptides generate an increase in the…”
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Population differentiation and conservation of endemic races: the butterfly, Plebejus argus by Thomas, C D, Glen, SWT, Lewis, O T, Hill, J K, Blakeley, D S

“…Five races of the Eurasian silver-studded blue butterfly, Plebejus argus, are restricted to different habitats in north Wales and north-west England. One of…”
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Pyrophosphate-dependent phosphofructokinase. Conservation of protein sequence between the alpha- and beta-subunits and with the ATP-dependent phosphofructokinase by Carlisle, S M, Blakeley, S D, Hemmingsen, S M, Trevanion, S J, Hiyoshi, T, Kruger, N J, Dennis, D T

“…Full-length cDNA clones for the alpha- and beta-subunits of pyrophosphate-fructose 6-phosphate 1-phosphotransferase have been isolated from a cDNA expression…”
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