Search Results - "Blake, RA"

In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship by MENDEL, Dirk B, LAIRD, A. Douglas, MURRAY, Lesley J, CARVER, Jeremy, CHAN, Emily, MOSS, Katherine G, HAZNEDAR, Joshua Ö, SUKBUNTHERNG, Juthamas, BLAKE, Robert A, LI SUN, CHO TANG, MILLER, Todd, XIAOHUA XIN, SHIRAZIAN, Sheri, MCMAHON, Gerald, CHERRINGTON, Julie M, LOUIE, Sharianne G, CHRISTENSEN, James G, GUANGMIN LI, SCHRECK, Randall E, ABRAMS, Tinya J, NGAI, Theresa J, LEE, Leslie B

“…One challenging aspect in the clinical development of molecularly targeted therapies, which represent a new and promising approach to treating cancers, has…”
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Abstract P4-04-07: Characterization of the effects of estrogen receptor alpha Y537S and D538G mutations on receptor function and pharmacology by Blake, RA, Hartman, SJ, Kleinheinz, TL, White, J, Daly, S, Goodwin, R, Zhou, W, Liang, J, Wang, X, O'Rourke, M, Metcalfe, C, Friedman, L

“…Abstract The frontline therapy for estrogen receptor alpha (ERα) positive Breast Cancer (ER+BC) involves various forms of endocrine therapy, consisting of…”
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Abstract GS3-05: Prospective optimization of estrogen receptor degradation yields ER ligands with variable capacities for ER transcriptional suppression by Metcalfe, C, Zhou, W, Guan, J, Daemen, A, Hafner, M, Blake, RA, Ingalla, E, Young, A, Oeh, J, De Bruyn, T, Ubhayakar, S, Chen, I, Giltnane, JM, Li, J, Wang, X, Sampath, D, Hager, JH, Friedman, LS

“…Abstract ER+ breast cancers can depend on ER signaling throughout disease progression, including after acquired resistance to existing endocrine agents,…”
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Abstract P5-04-07: GDC-9545: A novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes by Metcalfe, C, Ingalla, E, Blake, RA, Chang, J, Daemen, A, De Bruyn, T, Giltnane, JM, Guan, J, Hafner, M, Hartman, S, Kategaya, L, Kleinheinz, T, Liang, J, Mody, V, Nannini, M, Oeh, J, Ubhayakar, S, Wertz, I, Young, A, Zbieg, J, Zhou, W, Sampath, D, Friedman, LS, Wang, X

“…Abstract ER+ breast cancers depend on ER signaling throughout disease progression, including after acquired resistance to existing endocrine agents, providing…”
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SU6656, a Selective Src Family Kinase Inhibitor, Used To Probe Growth Factor Signaling by Blake, Robert A., Broome, Martin A., Liu, Xiangdong, Wu, Jianming, Gishizky, Mikhail, Sun, Li, Courtneidge, Sara A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors by LAIRD, A. D, VAJKOCZY, P, FONG, T. A. T, STRAWN, L. M, LI SUN, CHO TANG, HAWTIN, R, TANG, F, SHENOY, N, HIRTH, K. P, MCMAHON, G, CHERRINGTON, J. M, SHAWVER, L. K, THURNHER, A, CONGXIN LIANG, MOHAMMADI, M, SCHLESSINGER, J, ULLRICH, A, HUBBARD, S. R, BLAKE, R. A

“…Vascular endothelial growth factor, fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF) and their cognate receptor tyrosine kinases are…”
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Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion by Wang, Xueyan, Le, Phuong, Liang, Congxin, Chan, Julie, Kiewlich, David, Miller, Todd, Harris, Dave, Sun, Li, Rice, Audie, Vasile, Stefan, Blake, Robert A, Howlett, Anthony R, Patel, Neela, McMahon, Gerald, Lipson, Kenneth E

“…The hepatocyte growth factor/scatter factor (HGF/SF) receptor, Met, mediates various cellular responses on activation with its ligand, including proliferation,…”
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Src family kinase activity is required for signal tranducer and activator of transcription 3 and focal adhesion kinase phosphorylation and vascular endothelial growth factor signaling in vivo and for anchorage-dependent and -independent growth of human tumor cells by Laird, A Douglas, Li, Guangmin, Moss, Katherine G, Blake, Robert A, Broome, Martin A, Cherrington, Julie M, Mendel, Dirk B

“…The Src family kinases (SFKs) Src and Yes are believed to play critical roles in tumor growth, angiogenesis, invasion, and dissemination. Using a panel of…”
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The management of inappropriate vocalisation in dementia: a hierarchical approach by Barton, Sue, Findlay, David, Blake, Roger A.

“…Background Patients with dementia can demonstrate noisy behaviours such as screaming, repetitive speech, moaning and singing. Such behaviours can be grouped…”
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Design and synthesis of aminopropyl tetrahydroindole-based indolin-2-ones as selective and potent inhibitors of Src and Yes tyrosine kinase by Guan, Huiping, Laird, A.Douglas, Blake, Robert A., Tang, Cho, Liang, Chris

“…A novel series of substituted 3-[3-(aminopropyl)-4,5,6,7-tetrahydro-1 H-indol-2-ylmethylene]-1,3-dihydro-indole-2-ones was discovered as potent inhibitors of…”
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Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent by Mendel, D B, Laird, A D, Smolich, B D, Blake, R A, Liang, C, Hannah, A L, Shaheen, R M, Ellis, L M, Weitman, S, Shawver, L K, Cherrington, J M

“…Angiogenesis, or the sprouting of new blood vessels, is a central process in the growth of solid tumors. For many cancers, the extent of vascularization of a…”
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Collagen stimulates tyrosine phosphorylation of phospholipase C-gamma 2 but not phospholipase C-gamma 1 in human platelets by Blake, R A, Schieven, G L, Watson, S P

“…Collagen is an important primary stimulus of platelets during the process of hemostasis. As with many other platelet stimuli, collagen signal transduction…”
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A widely applicable, high-throughput TR-FRET assay for the measurement of kinase autophosphorylation: VEGFR-2 as a prototype by Moshinsky, Deborah J, Ruslim, Lany, Blake, Robert A, Tang, Flora

“…Homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET) assays represent a highly sensitive and robust high-throughput screening (HTS)…”
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An automated image capture and quantitation approach to identify proteins affecting tumor cell proliferation by Bhawe, Kaumudi M, Blake, Robert A, Clary, Douglas O, Flanagan, Peter M

“…To facilitate the characterization of proteins that negatively regulate tumor cell proliferation in vitro, the authors have implemented a high-throughput…”
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Activation of human platelets by peroxovanadate is associated with tyrosine phosphorylation of phospholipase Cγ and formation of inositol phosphates by BLAKE, R. A, WALKER, T. R, WATSON, S. P

“…Vanadate ions in the presence of H2O2 (peroxovanadate) induce a marked increase in the degree of tyrosine phosphorylation of proteins in human platelets. This…”
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Fcγ receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor by Blake, Robert A., Asselin, Judith, Walker, Trevor, Watson, Steve P.

“…We report that activation of phospholipase C (PLC) by cross-linking of the platelet low-affinity Fcγ receptor II (Fcγ RII) is inhibited by two structurally…”
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The use of inhibitors of protein kinases and protein phosphatases to investigate the role of protein phosphorylation in platelet activation by Watson, S P, Blake, R A, Lane, T, Walker, T R

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Src promotes PKCδ degradation by BLAKE, R. A, GARCIA-PARAMIO, P, PARKER, P. J, COURTNEIDGE, S. A

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Visualization of a recanalized umbilical vein on hepatobiliary imaging with CT correlation by Alexander, M S, Blake, R A, Gelman, R

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A method of integrating family nursing in an undergraduate curriculum by Blake, R A, Druck, A, Harsanyi, B, Hutchinson, S, Russell, P

“…The authors describe integrating theoretical content of families into an undergraduate curriculum based on the biopsychosocial spheres. Using audiovisual…”
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