Search Results - "Blake, E T"

Variably methylated retrotransposons are refractory to a range of environmental perturbations by Bertozzi, Tessa M., Becker, Jessica L., Blake, Georgina E. T., Bansal, Amita, Nguyen, Duy K., Fernandez-Twinn, Denise S., Ozanne, Susan E., Bartolomei, Marisa S., Simmons, Rebecca A., Watson, Erica D., Ferguson-Smith, Anne C.

“…The agouti viable yellow ( A vy ) allele is an insertional mutation in the mouse genome caused by a variably methylated intracisternal A particle (VM-IAP)…”
Get full text

Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker by Blake, Georgina E. T., Zhao, Xiaohui, Yung, Hong wa, Burton, Graham J., Ferguson-Smith, Anne C., Hamilton, Russell S., Watson, Erica D.

“…The mechanism behind transgenerational epigenetic inheritance is unclear, particularly through the maternal grandparental line. We previously showed that…”
Get full text

Quantifying the proportion of different cell types in the human cortex using DNA methylation profiles by Hannon, Eilis, Dempster, Emma L, Davies, Jonathan P, Chioza, Barry, Blake, Georgina E T, Burrage, Joe, Policicchio, Stefania, Franklin, Alice, Walker, Emma M, Bamford, Rosemary A, Schalkwyk, Leonard C, Mill, Jonathan

“…Due to interindividual variation in the cellular composition of the human cortex, it is essential that covariates that capture these differences are included…”
Get full text

Unravelling the complex mechanisms of transgenerational epigenetic inheritance by Blake, Georgina ET, Watson, Erica D

“…[Display omitted] •Epigenetic information can be altered by environmental stressors.•The mechanisms of epigenetic inheritance are complex and unclear.•DNA and…”
Get full text

Abnormal folate metabolism causes age‐, sex‐ and parent‐of‐origin‐specific haematological defects in mice by Padmanabhan, Nisha, Menelaou, Katerina, Gao, Jiali, Anderson, Alexander, Blake, Georgina E. T., Li, Tanya, Daw, B. Nuala, Watson, Erica D.

“…Key points Folate (folic acid) deficiency and mutations in folate‐related genes in humans result in megaloblastic anaemia. Folate metabolism, which requires…”
Get full text

Analysis of spermatogenesis and fertility in adult mice with a hypomorphic mutation in the Mtrr gene by Blake, Georgina E T, Hall, Jessica, Petkovic, Grace E, Watson, Erica D

“…Recent research has focussed on the significance of folate metabolism in male fertility. Knocking down the mouse gene Mtrr impedes the progression of folate…”
Get more information

Blastocyst transfer in mice alters the placental transcriptome and growth by Menelaou, Katerina, Prater, Malwina, Tunster, Simon J, Blake, Georgina E T, Geary Joo, Colleen, Cross, James C, Hamilton, Russell S, Watson, Erica D

“…Assisted reproduction technologies (ARTs) are becoming increasingly common. Therefore, how these procedures influence gene regulation and foeto-placental…”
Get full text

Multigenerational analysis of sex-specific phenotypic differences at midgestation caused by abnormal folate metabolism by Padmanabhan, Nisha, Rakoczy, Joanna, Kondratowicz, Monika, Menelaou, Katerina, Blake, Georgina E T, Watson, Erica D

“…The exposure to adverse environmental conditions (e.g. poor nutrition) may lead to increased disease risk in an individual and their descendants. In some…”
Get full text

Postcoital detection of a male-specific semen protein. Application to the investigation of rape by Graves, H C, Sensabaugh, G F, Blake, E T

“…Identification of semen in vaginal fluid may provide documentation of sexual contact in alleged victims of rape. We describe an enzyme-linked immunosorbent…”
Get more information

Anthelmintic profile of the cyclodepsipeptide PF1022A in in vitro and in vivo models by Conder, G A, Johnson, S S, Nowakowski, D S, Blake, T E, Dutton, F E, Nelson, S J, Thomas, E M, Davis, J P, Thompson, D P

“…A novel cyclodepsipeptide of fungal origin, PF1022A, recently was reported to have anthelmintic activity. To supplement published reports and determine…”
Get more information

Seminal plasma protein p30: simplified purification and evidence for identity with prostate specific antigen by Sensabaugh, G F, Blake, E T

“…A rapid high yield purification scheme is described for the major 30,000 molecular weight glycoprotein (p30) in human seminal plasma. Immunological and protein…”
Get more information

Using forensic techniques to verify self-reports of needle-sharing by Gibson, D R, Guydish, J R, Wraxall, B G, Blake, E T, Clark, G, Case, P

Get more information

Progressive desialidation of human transferrin by Blake, E T

“…Transferrin is a serum glycoprotein which contains four sialic acid residues located at the end of two branched carbohydrate structures. The presence of these…”
Get more information

Evidence that "vaginal peptidase" is a bacterial gene product by Blake, E T, Cook, Jr, C E, Bashinski, J S

“…A peptidase has been described in vaginal samples, termed "vaginal peptidase." This enzyme has been proposed as a tissue specific marker for vaginal debris. We…”
Get more information

Genetic markers in human semen. II: quantitation of polymorphic proteins by Blake, E T, Sensabaugh, G F

Get more information

Genetic markers in semen. III: Alteration of phosphoglucomutase isozyme patterns in semen contaminated with saliva by Sensabaugh, G F, Blake, E T, Northey, D H

“…Contamination of semen by saliva can result in the alteration of seminal phosphoglucomutase (PGM1) isozyme patterns. The alteration is characterized by the…”
Get more information

A microliter oxygen electrode system for sperm suspensions by Katz, D F, Blake, E T, Mills, R N, Fatt, I

“…A new polarographic oxygen electrode system is described which can accept sperm suspensions with volumes as low as 50 microliters. In this configuration, the…”
Get more information

Haptoglobin typing of bloodstains: electrophoresis of immunoprecipitated haptoglobin by Blake, E T, Sensabaugh, G F

Get more information

Discussion of "Effects of presumptive test reagents on the ability to obtain restriction fragment length polymorphism (RFLP) patterns from human blood and semen stains" by Barnett, P D, Blake, E T, Super-Mihalovich, J, Harmor, G, Rawlinson, L, Wraxall, B

Get more information

Sperm Diaphorase: Genetic Polymorphism of a Sperm-Specific Enzyme in Man by Caldwell, Kevin, Blake, Edward T., Sensabaugh, G. F.

“…Human sperm contains an enzyme with diaphorase activity that appears to be unique to sperm. Electrophoretic analysis of the diaphorase activity in sperm of…”
Get full text