Search Results - "Blaisdell, Thomas P"

Hydroxyl-Directed Cross-Coupling: A Scalable Synthesis of Debromohamigeran E and Other Targets of Interest by Blaisdell, Thomas P, Morken, James P

“…A hydroxyl functional group positioned β to a pinacol boronate can serve to direct palladium-catalyzed cross-coupling reactions. This feature can be used to…”
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EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model by Rhodin, Michael H J, McAllister, Nicole V, Castillo, Jonathan, Noton, Sarah L, Fearns, Rachel, Kim, In Jong, Yu, Jianming, Blaisdell, Thomas P, Panarese, Joseph, Shook, Brian C, Or, Yat Sun, Goodwin, Bryan, Lin, Kai

“…EDP-938 is a novel non-fusion replication inhibitor of respiratory syncytial virus (RSV). It is highly active against all RSV-A and B laboratory strains and…”
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Practical Silyl Protection of Ribonucleosides by Blaisdell, Thomas P, Lee, Sunggi, Kasaplar, Pinar, Sun, Xixi, Tan, Kian L

“…Herein we report the site-selective silylation of the ribonucelosides. The method enables a simple and efficient procedure for accessing suitably protected…”
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Hydroxyl-Directed Stereoselective Diboration of Alkenes by Blaisdell, Thomas P, Caya, Thomas C, Zhang, Liang, Sanz-Marco, Amparo, Morken, James P

“…An alkoxide-catalyzed directed diboration of alkenyl alcohols is described. This reaction occurs in a stereoselective fashion and is demonstrated with cyclic…”
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Distal-Selective Hydroformylation using Scaffolding Catalysis by Joe, Candice L, Blaisdell, Thomas P, Geoghan, Allison F, Tan, Kian L

“…In hydroformylation, phosphorus-based directing groups have been consistently successful at placing the aldehyde on the carbon proximal to the directing group…”
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Synthesis of 5'-O-DMT-2'-O-TBS Mononucleosides Using an Organic Catalyst by Lee, Sunggi, Blaisdell, Thomas P, Kasaplar, Pinar, Sun, Xixi, Tan, Kian L

“…This unit describes a highly effective method to produce 5'-O-DMT-2'-O-TBS mononucleosides selectively using a small organic catalyst. This methodology avoids…”
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