Search Results - "Blair, Tiffany"

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors by Duhen, Thomas, Duhen, Rebekka, Montler, Ryan, Moses, Jake, Moudgil, Tarsem, de Miranda, Noel F., Goodall, Cheri P., Blair, Tiffany C., Fox, Bernard A., McDermott, Jason E., Chang, Shu-Ching, Grunkemeier, Gary, Leidner, Rom, Bell, Richard Bryan, Weinberg, Andrew D.

“…Identifying tumor antigen-specific T cells from cancer patients has important implications for immunotherapy diagnostics and therapeutics. Here, we show that…”
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Cutting edge: the pathogenicity of IFN-γ-producing Th17 cells is independent of T-bet by Duhen, Rebekka, Glatigny, Simon, Arbelaez, Carlos A, Blair, Tiffany C, Oukka, Mohamed, Bettelli, Estelle

“…During the development of experimental autoimmune encephalomyelitis (EAE), the proportion of pathogenic and myelin-specific cells within CNS-infiltrating…”
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Evaluation of explant responses to STING ligands: personalized immunosurgical therapy for head and neck squamous cell carcinoma by Baird, Jason R, Bell, R Bryan, Troesch, Victoria, Friedman, David J, Bambina, Shelly, Kramer, Gwen, Blair, Tiffany, Medler, Terry R, Wu, Yaping, Sun, Zhaoyu, de Gruijl, Tanja D, van de Ven, Rieneke, Leidner, Rom, Crittenden, Marka R, Gough, Michael J

“…Surgeons have unique in situ access to tumors enabling them to apply immunotherapies to resection margins as a means to prevent local recurrence. Here we…”
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TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking by Gunderson, Andrew J., Yamazaki, Tomoko, McCarty, Kayla, Fox, Nathaniel, Phillips, Michaela, Alice, Alejandro, Blair, Tiffany, Whiteford, Mark, O’Brien, David, Ahmad, Rehan, Kiely, Maria X., Hayman, Amanda, Crocenzi, Todd, Gough, Michael J., Crittenden, Marka R., Young, Kristina H.

“…Transforming growth factor beta (TGFβ) is a multipotent immunosuppressive cytokine. TGFβ excludes immune cells from tumors, and TGFβ inhibition improves the…”
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Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors to Radiation Therapy by Blair, Tiffany C, Bambina, Shelly, Alice, Alejandro F, Kramer, Gwen F, Medler, Terry R, Baird, Jason R, Broz, Miranda L, Tormoen, Garth W, Troesch, Victoria, Crittenden, Marka R, Gough, Michael J

“…Radiation therapy is capable of directing adaptive immune responses against tumors by stimulating the release of endogenous adjuvants and tumor-associated Ags…”
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Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity by Crittenden, Marka R., Zebertavage, Lauren, Kramer, Gwen, Bambina, Shelly, Friedman, David, Troesch, Victoria, Blair, Tiffany, Baird, Jason R., Alice, Alejandro, Gough, Michael J.

“…Radiation therapy is a source of tumor antigen release that has the potential to serve as an endogenous tumor vaccination event. In preclinical models…”
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Defining Immunogenic and Radioimmunogenic Tumors by Medler, Terry R, Blair, Tiffany C, Crittenden, Marka R, Gough, Michael J

“…In the cancer literature tumors are inconsistently labeled as 'immunogenic', and experimental results are occasionally dismissed since they are only tested in…”
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Myeloid MyD88 restricts CD8+ T cell response to radiation therapy in pancreatic cancer by Medler, Terry R., Blair, Tiffany C., Alice, Alejandro F., Dowdell, Alexa K., Piening, Brian D., Crittenden, Marka R., Gough, Michael J.

“…Radiation therapy induces immunogenic cell death in cancer cells, whereby released endogenous adjuvants are sensed by immune cells to direct adaptive immune…”
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Targeting MerTK Enhances Adaptive Immune Responses After Radiation Therapy by Tormoen, Garth W., Blair, Tiffany C., Bambina, Shelly, Kramer, Gwen, Baird, Jason, Rahmani, Ramtin, Holland, John M., McCarty, Owen J.T., Baine, Michael J., Verma, Vivek, Nabavizadeh, Nima, Gough, Michael J., Crittenden, Marka

“…The role of MerTK, a member of the Tyro3-Axl-MerTK family of receptor tyrosine kinase, in the immune response to radiation therapy (RT) is unclear. We…”
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The Dynamic Entropy of Tumor Immune Infiltrates: The Impact of Recirculation, Antigen-Specific Interactions, and Retention on T Cells in Tumors by Blair, Tiffany C, Alice, Alejandro F, Zebertavage, Lauren, Crittenden, Marka R, Gough, Michael J

“…Analysis of tumor infiltration using conventional methods reveals a snapshot view of lymphocyte interactions with the tumor environment. However, lymphocytes…”
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Non‐Redundant Roles of T Cell Costimulation Pathways in Inflammatory Arthritis Revealed by Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN‐101) by Dillon, Stacey R., Evans, Lawrence S., Lewis, Katherine E., Debrot, Susan, Blair, Tiffany C., Mudri, Sherri, Kleist, Kayla, Levin, Steven D., Bhandari, Janhavi G., Garrett, Logan, Wolfson, Martin F., Holland, Pamela M., Rixon, Mark W., Peng, Stanford L.

“…Objective CD28 and inducible T cell costimulator (ICOS) appear to have nonredundant roles in T cell activation and adaptive immunity. We undertook this study…”
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ICOS is upregulated on T cells following radiation and agonism combined with radiation results in enhanced tumor control by Blair, Tiffany, Baird, Jason, Bambina, Shelly, Kramer, Gwen, Gostissa, Monica, Harvey, Christopher J., Gough, Michael J., Crittenden, Marka R.

“…Multiple preclinical studies have shown improved outcomes when radiation therapy is combined with immune modulating antibodies. However, to date, many of these…”
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Fluorescence tracking demonstrates T cell recirculation is transiently impaired by radiation therapy to the tumor by Kramer, Gwen, Blair, Tiffany, Bambina, Shelly, Kaur, Aanchal Preet, Alice, Alejandro, Baird, Jason, Friedman, David, Dowdell, Alexa K., Tomura, Michio, Grassberger, Clemens, Piening, Brian D., Crittenden, Marka R., Gough, Michael J.

“…T cells recirculate through tissues and lymphatic organs to scan for their cognate antigen. Radiation therapy provides site-specific cytotoxicity to kill…”
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Tumor resident memory CD8 T cells and concomitant tumor immunity develop independently of CD4 help by Medler, Terry R., Kramer, Gwen, Bambina, Shelly, Gunderson, Andrew J., Alice, Alejandro, Blair, Tiffany, Zebertavage, Lauren, Duhen, Thomas, Duhen, Rebekka, Young, Kristina, Crittenden, Marka R., Gough, Michael J.

“…Tissue resident memory (Trm) CD8 T cells infiltrating tumors represent an enriched population of tumor antigen-specific T cells, and their presence is…”
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Membrane-associated and secreted forms of the Rhesus macaque rhadinovirus-encoded CD200 homologue and cellular CD200 demonstrate differential effects on Rhesus Macaque CD200 Receptor signaling and regulation of myeloid cell activation by Estep, Ryan D, Govindan, Aparna N, Fitzpatrick, Kristin, Blair, Tiffany C, Rezaee, S A Rahim, Blackbourn, David J, Wong, Scott W

“…The CD200-CD200R pathway is involved in inhibition of immune responses, and the importance of this pathway to infectious disease is highlighted by the fact…”
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A platform for locoregional T-cell immunotherapy to control HNSCC recurrence following tumor resection by Sharon, Shay, Baird, Jason R, Bambina, Shelly, Kramer, Gwen, Blair, Tiffany C, Jensen, Shawn M, Leidner, Rom S, Bell, R Bryan, Casap, Nardy, Crittenden, Marka R, Gough, Michael J

“…Surgical resection of head and neck squamous-cell carcinoma (HNSCC) is associated with high rates of local and distant recurrence, partially mitigated by…”
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Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapy by Blair, Tiffany C, Bambina, Shelly, Kramer, Gwen F, Dowdell, Alexa K, Alice, Alejandro F, Baird, Jason R, Lund, Amanda W, Piening, Brian D, Crittenden, Marka R, Gough, Michael J

“…Radiation therapy generates extensive cancer cell death capable of promoting tumor-specific immunity. Within the tumor, conventional dendritic cells (cDCs) are…”
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Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis by Blair, Tiffany C, Manoharan, Minsha, Rawlings-Rhea, Stephanie D, Tagge, Ian, Kohama, Steven G, Hollister-Smith, Julie, Ferguson, Betsy, Woltjer, Randall L, Frederick, Meredith C, Pollaro, James, Rooney, William D, Sherman, Larry S, Bourdette, Dennis N, Wong, Scott W

“…Abstract Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at…”
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S276: POVETACICEPT (ALPN‐303), A POTENT DUAL BAFF/APRIL ANTAGONIST, FOR THE TREATMENT OF AUTOIMMUNE CYTOPENIAS AND OTHER ANTIBODY‐RELATED DISEASES by Dillon, Stacey, Davies, Rupert, Lickliter, Jason, Mclendon, Kristi, Manjarrez, Kristi Kristi L., Smith, Alina, Hudson, Krystalyn, Blanchfield, Lori, Sanderson, Russel, Chunyk, Allison, Blair, Tiffany, Enstrom, Amanda, Zayed, Hany, Peng, Stanford

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MRI of auto-transplantation of bone marrow-derived stem-progenitor cells for potential repair of injured arteries by Meng, Yanfeng, Zhang, Feng, Blair, Tiffany, Gu, Huidong, Feng, Hongqing, Wang, Jinnan, Yuan, Chun, Zhang, Zhaoqi, Qiu, Bensheng, Yang, Xiaoming

“…This study was to validate the feasibility of using clinical 3.0T MRI to monitor the migration of autotransplanted bone marrow (BM)-derived stem-progenitor…”
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