Search Results - "Blair, Paul W."

Differential Cytokine Signatures of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Influenza Infection Highlight Key Differences in Pathobiology by Karaba, Andrew H, Zhou, Weiqiang, Hsieh, Leon L, Figueroa, Alexis, Massaccesi, Guido, Rothman, Richard E, Fenstermacher, Katherine Z J, Sauer, Lauren, Shaw-Saliba, Kathryn, Blair, Paul W, Robinson, Matthew L, Leung, Sherry, Wesson, Russell, Alachkar, Nada, El-Diwany, Ramy, Ji, Hongkai, Cox, Andrea L

“…Abstract Background Several inflammatory cytokines are upregulated in severe coronavirus disease 2019 (COVID-19). We compared cytokines in COVID-19 versus…”
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Evidence of Orientia spp. Endemicity among Severe Infectious Disease Cohorts, Uganda by Blair, Paul W, Kobba, Kenneth, Okello, Stephen, Alharthi, Sultanah, Naluyima, Prossy, Clemens, Emily, Kibuuka, Hannah, Clark, Danielle V, Kakooza, Francis, Lamorde, Mohammed, Manabe, Yukari C, Dumler, J Stephen, Illness, Acute Febrile

“…At 3 severe infection cohort sites in Uganda, Orientia seropositivity was common. We identified 4 seroconversion cases and 1 PCR-positive case. These results…”
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Long COVID brain fog and muscle pain are associated with longer time to clearance of SARS-CoV-2 RNA from the upper respiratory tract during acute infection by Antar, Annukka A R, Yu, Tong, Demko, Zoe O, Hu, Chen, Tornheim, Jeffrey A, Blair, Paul W, Thomas, David L, Manabe, Yukari C

“…The incidence of long COVID is substantial, even in people with mild to moderate acute COVID-19. The role of early viral kinetics in the subsequent development…”
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Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes by Chenoweth, Josh G., Colantuoni, Carlo, Striegel, Deborah A., Genzor, Pavol, Brandsma, Joost, Blair, Paul W., Krishnan, Subramaniam, Chiyka, Elizabeth, Fazli, Mehran, Mehta, Rittal, Considine, Michael, Cope, Leslie, Knight, Audrey C., Elayadi, Anissa, Fox, Anne, Hertzano, Ronna, Letizia, Andrew G., Owusu-Ofori, Alex, Boakye, Isaac, Aduboffour, Albert A., Ansong, Daniel, Biney, Eno, Oduro, George, Schully, Kevin L., Clark, Danielle V.

“…Our limited understanding of the pathophysiological mechanisms that operate during sepsis is an obstacle to rational treatment and clinical trial design. There…”
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Metagenomic next generation sequencing of plasma RNA for diagnosis of unexplained, acute febrile illness in Uganda by Kandathil, Abraham J, Blair, Paul W, Lu, Jennifer, Anantharam, Raghavendran, Kobba, Kenneth, Robinson, Matthew L, Alharthi, Sultanah, Ndawula, Edgar C, Dumler, J Stephen, Kakooza, Francis, Lamorde, Mohammed, Thomas, David L, Salzberg, Steven L, Manabe, Yukari C

“…Metagenomic next generation metagenomic sequencing (mNGS) has proven to be a useful tool in the diagnosis and identification of novel human pathogens and…”
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Assessing the use of a micro-sampling device for measuring blood protein levels in healthy subjects and COVID-19 patients by Brandsma, Joost, Chenoweth, Josh G, Gregory, Melissa K, Krishnan, Subramaniam, Blair, Paul W, Striegel, Deborah A, Mehta, Rittal, Schully, Kevin L, Dumler, J. Stephen, Sikorski, CDR Cynthia S, O'Connor, Kelsey, Reichert-Scrivner, Susan A, Paguirigan, Carmen M, Uyehara, Catherine F. T, Ngauy, COL Viseth, Myers, Christopher A, Clark, Danielle V

“…Background Venous phlebotomy performed by trained personnel is critical for patient diagnosis and monitoring of chronic disease, but has limitations in…”
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Aetiology of hospitalized fever and risk of death at Arua and Mubende tertiary care hospitals in Uganda from August 2019 to August 2020 by Blair, Paul W, Kobba, Kenneth, Kakooza, Francis, Robinson, Matthew L, Candia, Emmanuel, Mayito, Jonathan, Ndawula, Edgar C, Kandathil, Abraham J, Matovu, Alphonsus, Aniku, Gilbert, Manabe, Yukari C, Lamorde, Mohammed

“…Epidemiology of febrile illness in Uganda is shifting due to increased HIV treatment access, emerging viruses, and increased surveillance. We investigated the…”
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A proof of concept for a targeted enrichment approach to the simultaneous detection and characterization of rickettsial pathogens from clinical specimens by Paskey, Adrian C, Schully, Kevin L, Voegtly, Logan J, Arnold, Catherine E, Cer, Regina Z, Frey, Kenneth G, Blair, Paul W, Clark, Danielle V, Ge, Hong, Richards, Allen L, Farris, Christina M, Bishop-Lilly, Kimberly A

“…Infection with either or is common, yet diagnostic capabilities are limited due to the short window for positive identification. Until now, although targeted…”
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Screening tools for predicting mortality of adults with suspected sepsis: an international sepsis cohort validation study by Blair, Paul W, Mehta, Rittal, Oppong, Chris Kwaku, Tin, Som, Ko, Emily, Tsalik, Ephraim L, Chenoweth, Josh, Rozo, Michelle, Adams, Nehkonti, Beckett, Charmagne, Woods, Christopher W, Striegel, Deborah A, Salvador, Mark G, Brandsma, Joost, McKean, Lauren, Mahle, Rachael E, Hulsey, William R, Krishnan, Subramaniam, Prouty, Michael, Letizia, Andrew, Fox, Anne, Faix, Dennis, Lawler, James V, Duplessis, Chris, Gregory, Michael G, Vantha, Te, Owusu-Ofori, Alex Kwame, Ansong, Daniel, Oduro, George, Schully, Kevin L, Clark, Danielle V

“…ObjectivesWe evaluated the performance of commonly used sepsis screening tools across prospective sepsis cohorts in the USA, Cambodia and…”
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Additive value of lung ultrasound to clinical parameters for prognosticating COVID-19 by Siddharthan, Trishul, Blair, Paul W, Cui, Erjia, Pearce, Jackson, Herrera, Phabiola, Liu, Gigi, East, Joshua, Crainiceanu, Ciprian, Clark, Danielle V

“…https://bit.ly/3InePYK…”
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Virulence of Marburg Virus Angola Compared to Mt. Elgon (Musoke) in Macaques: A Pooled Survival Analysis by Blair, Paul W, Keshtkar-Jahromi, Maryam, Psoter, Kevin J, Reisler, Ronald B, Warren, Travis K, Johnston, Sara C, Goff, Arthur J, Downey, Lydia G, Bavari, Sina, Cardile, Anthony P

“…Angola variant (MARV/Ang) has replaced Mt. Elgon variant Musoke isolate (MARV/MtE-Mus) as the consensus standard variant for Marburg virus research and is…”
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Sepsis endotypes identified by host gene expression across global cohorts by Chenoweth, Josh G., Brandsma, Joost, Striegel, Deborah A., Genzor, Pavol, Chiyka, Elizabeth, Blair, Paul W., Krishnan, Subramaniam, Dogbe, Elliot, Boakye, Isaac, Fogel, Gary B., Tsalik, Ephraim L., Woods, Christopher W., Owusu-Ofori, Alex, Oppong, Chris, Oduro, George, Vantha, Te, Letizia, Andrew G., Beckett, Charmagne G., Schully, Kevin L., Clark, Danielle V.

“…Background Sepsis from infection is a global health priority and clinical trials have failed to deliver effective therapeutic interventions. To address…”
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Do worsening lung ultrasound scans identify severe COVID-19 trajectories? by Blair, Paul W, Hwang, Jimin, Pearce, Jackson, Fong, Tiffany C, Cui, Erjia, Herrera, Phabiola, Liu, Gigi, Crainiceanu, Ciprian, Siddharthan, Trishul, Clark, Danielle V

“…While point-of-care ultrasound (POCUS) has been used to track worsening COVID-19 disease it is unclear if there are dynamic differences between severity…”
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Point-of-Care Lung Ultrasound Predicts Severe Disease and Death Due to COVID-19: A Prospective Cohort Study by Blair, Paul W, Siddharthan, Trishul, Liu, Gigi, Bai, Jiawei, Cui, Erja, East, Joshua, Herrera, Phabiola, Anova, Lalaine, Mahadevan, Varun, Hwang, Jimin, Hossen, Shakir, Seo, Stefanie, Sonuga, Olamide, Lawrence, Joshua, Peters, Jillian, Cox, Andrea L, Manabe, Yukari C, Fenstermacher, Katherine, Shea, Sophia, Rothman, Richard E, Hansoti, Bhakti, Sauer, Lauren, Crainiceanu, Ciprian, Clark, Danielle V

“…The clinical utility of point-of-care lung ultrasound (LUS) among hospitalized patients with COVID-19 is unclear. Prospective cohort study. A large tertiary…”
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Rickettsioses and Q Fever in Tanzania: Estimating the Burden of Pervasive and Neglected Causes of Severe Febrile Illness in Sub-Saharan Africa by Blair, Paul W, Lamorde, Mohammed, Dumler, J Stephen

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Durable SARS-CoV-2 B cell immunity after mild or severe disease by Ogega, Clinton O, Skinner, Nicole E, Blair, Paul W, Park, Han-Sol, Littlefield, Kirsten, Ganesan, Abhinaya, Dhakal, Santosh, Ladiwala, Pranay, Antar, Annukka Ar, Ray, Stuart C, Betenbaugh, Michael J, Pekosz, Andrew, Klein, Sabra L, Manabe, Yukari C, Cox, Andrea L, Bailey, Justin R

“…Multiple studies have shown loss of severe acute respiratory syndrome coronavirus 2-specific (SARS-CoV-2-specific) antibodies over time after infection,…”
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Implementation of an International Severe Infection Point-of-Care Ultrasound Research Network by Herrera, Phabiola M, Blair, Paul W, Siddharthan, Trishul, Fong, Tiffany, Pollett, Simon, Clark, Danielle V

“…Point-of-care ultrasound (POCUS) is a rapid, readily available, and cost-effective diagnostic and prognostic modality in a range of clinical settings. However,…”
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Distinct Cytokine and Chemokine Dysregulation in Hospitalized Children With Acute Coronavirus Disease 2019 and Multisystem Inflammatory Syndrome With Similar Levels of Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 Shedding by Peart Akindele, Nadine, Kouo, Theodore, Karaba, Andrew H, Gordon, Oren, Fenstermacher, Katherine Z J, Beaudry, Jeanette, Rubens, Jessica H, Atik, Christine C, Zhou, Weiqiang, Ji, Hongkai, Tao, Xueting, Vaidya, Dhananjay, Mostafa, Heba, Caturegli, Patrizio, Blair, Paul W, Sauer, Lauren, Cox, Andrea L, Persaud, Deborah

“…Abstract Background Multisystem inflammatory syndrome in children (MIS-C) is a severe clinical phenotype of severe acute respiratory syndrome coronavirus 2…”
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Validation of Lung Ultrasound for Coronavirus Disease 2019 Prognostication in an International Multicenter Cohort Study by Blair, Paul W, Siddharthan, Trishul, Herrera, Phabiola M, Cui, Erjia, Waitt, Peter, Hossen, Shakir, Fong, Tiffany C, Anova, Lalaine, Erazo, Hector, Mount, Cristin, Pettrone, Kristen, Rothman, Richard E, Pollett, Simon D, Crainiceanu, Ciprian, Clark, Danielle V, Kayiira, Mubaraka, Wailagala, Abdullah, Okello, Stephen, Kibuuka, Hannah, Dalzell, Molly, Liu, Gigi, Woods, Chris, Columbo, Rhonda, Ganesan, Anu, Hull, Aicha M, Richard, Stephanie A

“…Abstract Background Despite many studies evaluating lung ultrasound (LUS) for coronavirus disease 2019 (COVID-19) prognostication, the generalizability and…”
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Transfusing Convalescent Plasma as Post-Exposure Prophylaxis Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Double-Blinded, Phase 2 Randomized, Controlled Trial by Shoham, Shmuel, Bloch, Evan M, Casadevall, Arturo, Hanley, Daniel, Lau, Bryan, Gebo, Kelly, Cachay, Edward, Kassaye, Seble G, Paxton, James H, Gerber, Jonathan, Levine, Adam C, Naeim, Arash, Currier, Judith, Patel, Bela, Allen, Elizabeth S, Anjan, Shweta, Appel, Lawrence, Baksh, Sheriza, Blair, Paul W, Bowen, Anthony, Broderick, Patrick, Caputo, Christopher A, Cluzet, Valerie, Cordisco, Marie Elena, Cruser, Daniel, Ehrhardt, Stephan, Forthal, Donald, Fukuta, Yuriko, Gawad, Amy L, Gniadek, Thomas, Hammel, Jean, Huaman, Moises A, Jabs, Douglas A, Jedlicka, Anne, Karlen, Nicky, Klein, Sabra, Laeyendecker, Oliver, Lane, Karen, McBee, Nichol, Meisenberg, Barry, Merlo, Christian, Mosnaim, Giselle, Park, Han-Sol, Pekosz, Andrew, Petrini, Joann, Rausch, William, Shade, David M, Shapiro, Janna R, Singleton, J Robinson, Sutcliffe, Catherine, Thomas, David L, Yarava, Anusha, Zand, Martin, Zenilman, Jonathan M, Tobian, Aaron A R, Sullivan, David J

“…The efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) convalescent plasma (CCP) for preventing infection in exposed, uninfected…”
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