Search Results - "Blair, Paul A."

A Regulatory Feedback between Plasmacytoid Dendritic Cells and Regulatory B Cells Is Aberrant in Systemic Lupus Erythematosus by Menon, Madhvi, Blair, Paul A., Isenberg, David A., Mauri, Claudia

“…Signals controlling the generation of regulatory B (Breg) cells remain ill-defined. Here we report an “auto”-regulatory feedback mechanism between plasmacytoid…”
Get full text

Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells by Rosser, Elizabeth C., Piper, Christopher J.M., Matei, Diana E., Blair, Paul A., Rendeiro, André F., Orford, Michael, Alber, Dagmar G., Krausgruber, Thomas, Catalan, Diego, Klein, Nigel, Manson, Jessica J., Drozdov, Ignat, Bock, Christoph, Wedderburn, Lucy R., Eaton, Simon, Mauri, Claudia

“…The differentiation of IL-10-producing regulatory B cells (Bregs) in response to gut-microbiota-derived signals supports the maintenance of tolerance. However,…”
Get full text

Circulating and intrahepatic antiviral B cells are defective in hepatitis B by Burton, Alice R, Pallett, Laura J, McCoy, Laura E, Suveizdyte, Kornelija, Amin, Oliver E, Swadling, Leo, Alberts, Elena, Davidson, Brian R, Kennedy, Patrick Tf, Gill, Upkar S, Mauri, Claudia, Blair, Paul A, Pelletier, Nadege, Maini, Mala K

“…B cells are increasingly recognized as playing an important role in the ongoing control of hepatitis B virus (HBV). The development of antibodies against the…”
Get full text

The Incognito Journey of a Regulatory B Cell by Mauri, Claudia, Blair, Paul A.

“…Regulatory B cells have largely been reported as B cells at a developmental stage before plasma cell differentiation. Matsumoto et al. (2014) report that…”
Get full text

Regulatory B cells in autoimmunity: developments and controversies by Mauri, Claudia, Blair, Paul A

“…Knowledge of the role of regulatory B (B REG ) cells in immune suppression and autoimmunity has improved. In this Review, the authors describe the advances in…”
Get full text

Cellular targets of regulatory B cell-mediated suppression by Rosser, Elizabeth C, Blair, Paul A, Mauri, Claudia

“…Regulatory B cells (Bregs) are defined by their ability to restrain inflammatory responses both in vivo and in vitro. Interleukin 10 (IL-10) production by…”
Get full text

CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients by Blair, Paul A, Noreña, Lina Yassin, Flores-Borja, Fabian, Rawlings, David J, Isenberg, David A, Ehrenstein, Michael R, Mauri, Claudia

“…The immunosuppressive function of regulatory B cells has been shown in several murine models of chronic inflammation, including collagen-induced arthritis,…”
Get full text

Regulatory B cells in CVID patients fail to suppress multifunctional IFN-γ+ TNF-α+ CD4+ T cells differentiation by Vlkova, Marcela, Ticha, Olga, Nechvatalova, Jana, Kalina, Tomas, Litzman, Jiri, Mauri, Claudia, Blair, Paul A

“…Abstract Common variable immunodeficiency (CVID) refers to primary hypogammaglobulinemia with unknown pathogenesis. Although there is evidence for intrinsic B…”
Get full text

Editorial: Regulatory B Cells: Are We Really Ready to Manipulate Them for the Benefit of Patients With Autoimmune Diseases? by Mauri, Claudia, Blair, Paul A.

Get full text

Selective Targeting of B Cells with Agonistic Anti-CD40 Is an Efficacious Strategy for the Generation of Induced Regulatory T2-Like B Cells and for the Suppression of Lupus in MRL/lpr Mice by Blair, Paul A, Chavez-Rueda, Karina A, Evans, Jamie G, Shlomchik, Mark J, Eddaoudi, Ayad, Isenberg, David A, Ehrenstein, Michael R, Mauri, Claudia

“…We have previously reported that IL-10(+) regulatory B cells, known to play an important role in controlling autoimmunity and inflammatory disorders, are…”
Get full text

Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease by Matei, Diana E, Menon, Madhvi, Alber, Dagmar G, Smith, Andrew M, Nedjat-Shokouhi, Bahman, Fasano, Alessio, Magill, Laura, Duhlin, Amanda, Bitoun, Samuel, Gleizes, Aude, Hacein-Bey-Abina, Salima, Manson, Jessica J, Rosser, Elizabeth C, Klein, Nigel, Blair, Paul A, Mauri, Claudia

“…Evidence suggests an important role for gut-microbiota dysbiosis in the development of rheumatoid arthritis (RA). The link between changes in gut bacteria and…”
Get more information

CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients by Blair, Paul A., Noreña, Lina Yassin, Flores-Borja, Fabian, Rawlings, David J., Isenberg, David A., Ehrenstein, Michael R., Mauri, Claudia

“…The immunosuppressive function of regulatory B cells has been shown in several murine models of chronic inflammation, including collagen-induced arthritis,…”
Get full text

A role for gut-associated lymphoid tissue in shaping the human B cell repertoire by Vossenkämper, Anna, Blair, Paul A, Safinia, Niloufar, Fraser, Louise D, Das, Lisa, Sanders, Theodore J, Stagg, Andrew J, Sanderson, Jeremy D, Taylor, Kirstin, Chang, Fuju, Choong, Lee M, D'Cruz, David P, Macdonald, Thomas T, Lombardi, Giovanna, Spencer, Jo

“…We have tracked the fate of immature human B cells at a critical stage in their development when the mature B cell repertoire is shaped. We show that a major…”
Get full text

B regulatory cells are increased in hypercholesterolaemic mice and protect from lesion development via IL-10 by Strom, Asa C, Cross, Amanda J, Cole, Jennifer E, Blair, Paul A, Leib, Christoph, Goddard, Michael E, Rosser, Elizabeth C, Park, Inhye, Hultgårdh Nilsson, Anna, Nilsson, Jan, Mauri, Claudia, Monaco, Claudia

“…Whilst innate B1-B cells are atheroprotective, adaptive B2-B cells are considered pro-atherogenic. Different subsets of B regulatory cells (B(reg)) have been…”
Get more information

Transitional‐2 B cells acquire regulatory function during tolerance induction and contribute to allograft survival by Moreau, Aurélie, Blair, Paul A., Chai, Jian‐Guo, Ratnasothy, Kulachelvy, Stolarczyk, Emilie, Alhabbab, Rowa, Rackham, Chloe L., Jones, Peter M., Smyth, Lesley, Elgueta, Raul, Howard, Jane K., Lechler, Robert I., Lombardi, Giovanna

“…In humans, tolerance to renal transplants has been associated with alterations in B‐cell gene transcription and maintenance of the numbers of circulating…”
Get full text

IL-10 secreting regulatory B cells are potent arbiters of autoimmunity in both mouse and man by Mauri, Claudia, Flores-Borja, Fabian, Blair, Paul A, Carter, Natalie A

Get full text

B Cell Activation and B Cell Tolerance by Oleinika, Kristine, Mauri, Claudia, Blair, Paul A

Get full text

Circulating and intrahepatic antiviral B cells are defective in hepatitis B by Burton, Alice R, Pallett, Laura J, McCoy, Laura E, Suveizdyte, Kornelija, Amin, Oliver E, Swadling, Leo, Alberts, Elena, Davidson, Brian R, Kennedy, Patrick T F, Gill, Upkar S, Mauri, Claudia, Blair, Paul A, Pelletier, Nadege, Maini, Mala K

“…B cells are increasingly recognized as playing an important role in the ongoing control of hepatitis B virus (HBV). The development of antibodies against the…”
Get full text

CD19 +CD24 hiCD38 hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients by Blair, Paul A., Noreña, Lina Yassin, Flores-Borja, Fabian, Rawlings, David J., Isenberg, David A., Ehrenstein, Michael R., Mauri, Claudia

“…The immunosuppressive function of regulatory B cells has been shown in several murine models of chronic inflammation, including collagen-induced arthritis,…”
Get full text

Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice1 by Blair, Paul A., Chavez-Rueda, Karina A., Evans, Jamie G., Shlomchik, Mark J., Eddaoudi, Ayad, Isenberg, David A., Ehrenstein, Michael R., Mauri, Claudia

“…We have previously reported that IL10 + regulatory B cells, known to play an important role in controlling autoimmunity and inflammatory disorders, are…”
Get full text