Search Results - "Blair, Jessica M.A."

Molecular mechanisms of antibiotic resistance by Blair, Jessica M. A., Webber, Mark A., Baylay, Alison J., Ogbolu, David O., Piddock, Laura J. V.

“…Key Points Antibiotic resistance is a global health emergency. Resistance mechanisms exist for all current antibiotics, and few new drugs are in development…”
Get full text

The role of bacterial transport systems in the removal of host antimicrobial peptides in Gram-negative bacteria by Blair, Jessica M A, Zeth, Kornelius, Bavro, Vassiliy N, Sancho-Vaello, Enea

“…Abstract Antibiotic resistance is a global issue that threatens our progress in healthcare and life expectancy. In recent years, antimicrobial peptides (AMPs)…”
Get full text

Antiviral, Antimicrobial and Antibiofilm Activity of Selenoesters and Selenoanhydrides by Spengler, Gabriella, Kincses, Annamária, Mosolygó, Tímea, Marć, Małgorzata Anna, Nové, Márta, Gajdács, Márió, Sanmartín, Carmen, McNeil, Helen E, Blair, Jessica M A, Domínguez-Álvarez, Enrique

“…Selenoesters and the selenium isostere of phthalic anhydride are bioactive selenium compounds with a reported promising activity in cancer, both due to their…”
Get full text

Bacterial flagellin promotes viral entry via an NF-kB and Toll Like Receptor 5 dependent pathway by Benedikz, Elizabeth K., Bailey, Dalan, Cook, Charlotte N. L., Gonçalves-Carneiro, Daniel, Buckner, Michelle M. C., Blair, Jessica M. A., Wells, Timothy J., Fletcher, Nicola F., Goodall, Margaret, Flores-Langarica, Adriana, Kingsley, Robert A., Madsen, Jens, Teeling, Jessica, Johnston, Sebastian L., MacLennan, Calman A., Balfe, Peter, Henderson, Ian R., Piddock, Laura J. V., Cunningham, Adam F., McKeating, Jane A.

“…Viruses and bacteria colonize hosts by invading epithelial barriers. Recent studies have shown that interactions between the microbiota, pathogens and the host…”
Get full text

Molecular mechanisms of antibiotic resistance revisited by Darby, Elizabeth M., Trampari, Eleftheria, Siasat, Pauline, Gaya, Maria Solsona, Alav, Ilyas, Webber, Mark A., Blair, Jessica M. A.

“…Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics currently in clinical use and only a few novel drugs in the…”
Get full text

Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria by Alav, Ilyas, Kobylka, Jessica, Kuth, Miriam S, Pos, Klaas M, Picard, Martin, Blair, Jessica M. A, Bavro, Vassiliy N

“…Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative organisms are diverse in function, energization, and structural…”
Get full text

Microbial Primer: Multidrug efflux pumps by Siasat, Pauline Ann, Blair, Jessica M A

“…Multidrug efflux pumps are molecular machines that sit in the bacterial cell membrane and pump molecules out from either the periplasm or cytoplasm to outside…”
Get full text

Interchangeability of periplasmic adaptor proteins AcrA and AcrE in forming functional efflux pumps with AcrD in Salmonella enterica serovar Typhimurium by Alav, Ilyas, Bavro, Vassiliy N, Blair, Jessica M A

“…Abstract Background Resistance-nodulation-division (RND) efflux pumps are important mediators of antibiotic resistance. RND pumps, including the principal…”
Get full text

Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance by Blair, Jessica M A, Richmond, Grace E, Piddock, Laura J V

“…Gram-negative bacteria express a plethora of efflux pumps that are capable of transporting structurally varied molecules, including antibiotics, out of the…”
Get more information

E. coli ST11 (O157:H7) does not encode a functional AcrF efflux pump by Pugh, Hannah L, Connor, Christopher, Siasat, Pauline, McNally, Alan, Blair, Jessica M A

“…is a facultative anaerobe found in a wide range of environments. Commonly described as the laboratory workhorse, is one of the best characterized bacterial…”
Get full text

Antibiotic entrapment in antibacterial micelles as a novel strategy for the delivery of challenging antibiotics from silica nanoparticles by Muguruza, Asier R., Odyniec, Maria L., Manhota, Menisha, Habib, Zaina, Rurack, Knut, Blair, Jessica M.A., Kuehne, Sarah A., Walmsley, A. Damien, Pikramenou, Zoe

“…Silica materials are popular in biomedical applications as composites and drug delivery platforms due to their low toxicity and biocompatibility. Mesoporous…”
Get full text

Candida albicans enhances meropenem tolerance of Pseudomonas aeruginosa in a dual-species biofilm by Alam, Farhana, Catlow, Dominic, Di Maio, Alessandro, Blair, Jessica M A, Hall, Rebecca A

“…Abstract Background Pseudomonas aeruginosa is an opportunistic bacterium that infects the airways of cystic fibrosis patients, surfaces of surgical and burn…”
Get full text

How to Measure Export via Bacterial Multidrug Resistance Efflux Pumps by Blair, Jessica M A, Piddock, Laura J V

“…Bacterial multidrug resistance (MDR) efflux pumps are an important mechanism of antibiotic resistance and are required for many pathogens to cause infection…”
Get full text

Transcriptional profiling of Pseudomonas aeruginosa mature single- and dual-species biofilms in response to meropenem by Alam, Farhana, Blair, Jessica M A, Hall, Rebecca A

“…is a Gram-negative opportunistic pathogen frequently isolated from chronic infections of the cystic fibrosis lung and burn wounds, and is a major cause of…”
Get full text

A climate for antibiotic resistance by Blair, Jessica M. A.

“…Antibiotic resistance is a growing global health crisis. Research now suggests that higher local temperatures are associated with a greater incidence of…”
Get full text

RND efflux pumps in Gram-negative bacteria; regulation, structure and role in antibiotic resistance by Colclough, Abigail L, Alav, Ilyas, Whittle, Emily E, Pugh, Hannah L, Darby, Elizabeth M, Legood, Simon W, McNeil, Helen E, Blair, Jessica Ma

“…Rresistance-nodulation-division (RND) efflux pumps in Gram-negative bacteria remove multiple, structurally distinct classes of antimicrobials from inside…”
Get full text

Contribution of the efflux pump AcrAB-TolC to the tolerance of chlorhexidine and other biocides in Klebsiella spp by Wand, Matthew E, Darby, Elizabeth M, Blair, Jessica M A, Sutton, J Mark

“…We are becoming increasingly reliant on the effectiveness of biocides to combat the spread of Gram-negative multi-drug-resistant (MDR) pathogens, including …”
Get full text

Transferable Acinetobacter baumannii plasmid pDETAB2 encodes OXA-58 and NDM-1 and represents a new class of antibiotic resistance plasmids by Liu, Haiyang, Moran, Robert A, Chen, Ying, Doughty, Emma L, Hua, Xiaoting, Jiang, Yan, Xu, Qingye, Zhang, Linghong, Blair, Jessica M A, McNally, Alan, van Schaik, Willem, Yu, Yunsong

“…Abstract Objectives To characterize a blaOXA-58- and blaNDM-1-containing MDR plasmid from a rare Acinetobacter baumannii lineage and compare it with related…”
Get full text

Dynamic Boolean modelling reveals the influence of energy supply on bacterial efflux pump expression by Kerr, Ryan, Jabbari, Sara, Blair, Jessica M A, Johnston, Iain G

“…Antimicrobial resistance (AMR) is a global health issue. One key factor contributing to AMR is the ability of bacteria to export drugs through efflux pumps,…”
Get full text

AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity by Blair, Jessica M. A., Bavro, Vassiliy N., Ricci, Vito, Modi, Niraj, Cacciotto, Pierpaolo, Kleinekathӧfer, Ulrich, Ruggerone, Paolo, Vargiu, Attilio V., Baylay, Alison J., Smith, Helen E., Brandon, Yvonne, Galloway, David, Piddock, Laura J. V.

“…Significance Genome sequencing of a multidrug-resistant clinical isolate of Salmonella Typhimurium from a patient that failed ciprofloxacin therapy revealed a…”
Get full text