Heritability and Genetic Linkage of Left Ventricular Mass, Systolic and Diastolic Function in Hypertensive African Americans (From the GENOA Study)

Heritability and Genetic Linkage of Left Ventricular Mass, Systolic and Diastolic Function in Hypertensive African Americans (From the GENOA Study)

Background Much of the interindividual variation in left ventricular (LV) structure and function is unexplained by established risk factors and may be due to novel or genetic factors. We used pedigree information from 454 tandem markers across the genome to estimate the heritability and linkage of v...

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Bibliographic Details
Published in:American journal of hypertension Vol. 23; no. 8; pp. 870 - 875
Main Authors: Fox, Ervin R., Klos, Kathy L., Penman, Alan D., Blair, George J., Blossom, Benjamin D., Arnett, Donna, Devereux, Richard B., Samdarshi, Tandaw, Boerwinkle, Eric, Mosley, Thomas H.
Format: Journal Article
Language:English
Published: United States Oxford University Press 01-08-2010
Subjects:
African Americans
African Americans - genetics
Aged
blood pressure
Cohort Studies
Diastole - genetics
Echocardiography
Female
Genetic Linkage
genetics
Heart Ventricles - anatomy & histology
Heart Ventricles - diagnostic imaging
Humans
hypertension
Hypertension - diagnostic imaging
Hypertension - genetics
Hypertension - pathology
Hypertrophy, Left Ventricular - genetics
left ventricular mass
Lod Score
Male
Middle Aged
Pedigree
Systole - genetics
Ventricular Function, Left - genetics
African Americans
blood pressure
genetics
hypertension
left ventricular mass
echocardiography
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Summary:Background Much of the interindividual variation in left ventricular (LV) structure and function is unexplained by established risk factors and may be due to novel or genetic factors. We used pedigree information from 454 tandem markers across the genome to estimate the heritability and linkage of various echocardiographic measures of LV structure and function in a cohort of African-American hypertensive siblings. Methods LV mass was calculated according to the American Society of Echocardiography (ASE) simplified cubed equation and indexed to height2.7. Fractional shortening (FS) was calculated as the percent change in the internal diameter between diastole and systole. Ejection fraction (EF) was calculated from ventricular diameters. Peak mitral early and late diastolic filling velocities were measured from the transmitral pulsed Doppler profile. The maximum-likelihood heritability estimate for each phenotype was obtained using a variance components method. Linkage analyses were performed using the multipoint variance components-based approach. Results There was moderate heritability for LV mass index (34%), interventricular septal thickness (29%), diastolic diameter (42%), EF (40%), FS (39%), and mitral early and late diastolic filling velocities (37 and 45%, respectively). The greatest evidence of genetic linkage was observed for LV mass index on chromosome 3 (logarithm of odds (LOD) score = 2.38), LV EF on chromosome 12 (LOD score = 2.39), and mitral E-wave velocity (MVE) on chromosome 19 (LOD score = 2.69). Conclusions In this African-American cohort of hypertensive siblings, the greatest evidence for linkage of LV structure and function was on chromosomes 3, 12, and 19.
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ISSN:0895-7061
1941-7225
1879-1905
DOI:10.1038/ajh.2010.67