Search Results - "Blaine, Logan J."

Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing by Leibowitz, Mitchell L., Papathanasiou, Stamatis, Doerfler, Phillip A., Blaine, Logan J., Sun, Lili, Yao, Yu, Zhang, Cheng-Zhong, Weiss, Mitchell J., Pellman, David

“…Genome editing has therapeutic potential for treating genetic diseases and cancer. However, the currently most practicable approaches rely on the generation of…”
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Mechanisms generating cancer genome complexity from a single cell division error by Umbreit, Neil T, Zhang, Cheng-Zhong, Lynch, Luke D, Blaine, Logan J, Cheng, Anna M, Tourdot, Richard, Sun, Lili, Almubarak, Hannah F, Judge, Kim, Mitchell, Thomas J, Spektor, Alexander, Pellman, David

“…The chromosome breakage-fusion-bridge (BFB) cycle is a mutational process that produces gene amplification and genome instability. Signatures of BFB cycles can…”
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Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing by Papathanasiou, Stamatis, Markoulaki, Styliani, Blaine, Logan J., Leibowitz, Mitchell L., Zhang, Cheng-Zhong, Jaenisch, Rudolf, Pellman, David

“…Karyotype alterations have emerged as on-target complications from CRISPR-Cas9 genome editing. However, the events that lead to these karyotypic changes in…”
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