Search Results - "Blagg, B"

Natural product inhibitors of Hsp90: potential leads for drug discovery by Amolins, M W, Blagg, B S J

“…Heat shock protein 90 has emerged as a promising target for the treatment of cancer and neurodegenerative diseases. This review summarizes recent advancements…”
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Selective HSP90β inhibition results in TNF and TRAIL mediated HIF1α degradation by Heck, A.L., Mishra, S., Prenzel, T., Feulner, L., Achhammer, E., Särchen, V., Blagg, B.S.J., Schneider-Brachert, W., Schütze, S., Fritsch, J.

“…Signaling via TNF-R1 mediates pleiotropic biological outcomes ranging from inflammation and proliferation to cell death. Previous reports demonstrated that…”
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Novel C-Terminal Heat Shock Protein 90 Inhibitors (KU711 and Ku757) Are Effective in Targeting Head and Neck Squamous Cell Carcinoma Cancer Stem cells by Subramanian, C., Kovatch, K.J., Sim, M.W., Wang, G., Prince, M.E., Carey, T.E., Davis, R., Blagg, B.S.J., Cohen, M.S.

“…Advanced head and neck squamous cell carcinoma (HNSCC) remains a therapeutic challenge due to the development of therapy resistance. Several studies have…”
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Dimeric approaches to anti-cancer chemotherapeutics by Hadden, M K, Blagg, B S J

“…Numerous proteins responsible for cell proliferation and differentiation exist either as hetero or homodimers or become activated through dimerization as a key…”
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KU135 a HPS90 Inhibitor Induced Cell Death In Melanoma Cells by Samadi, A.K, Mukerji, R, Zhang, X, Blagg, B, Cohen, M.S

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1-Deoxy-D-xylulose 5-phosphate synthase, the gene product of open reading frame (ORF) 2816 and ORF 2895 in Rhodobacter capsulatus by Hahn, F M, Eubanks, L M, Testa, C A, Blagg, B S, Baker, J A, Poulter, C D

“…In eubacteria, green algae, and plant chloroplasts, isopentenyl diphosphate, a key intermediate in the biosynthesis of isoprenoids, is synthesized by the…”
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P123The rescue of Ca2+ cycling abnormalities conferred by HCM-causing mutations with analogues of the green tea polyphenol epigallocatechin-3-gallate by Robinson, P, Liu, X, Zhang, Y-H, Khandelwal, A, Blagg, B, Casadei, B, Watkins, H, Redwood, C

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E. coli MEP Synthase:  Steady-State Kinetic Analysis and Substrate Binding by Koppisch, Andrew T, Fox, David T, Blagg, Brian S. J, Poulter, C. D

“…2-C-Methyl-d-erythritol-4-phosphate synthase (MEP synthase) catalyzes the rearrangement/reduction of 1-d-deoxyxylulose-5-phosphate (DXP) to…”
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Synthesis of 2-C-Methyl-d-erythritol 4-Phosphate:  The First Pathway-Specific Intermediate in the Methylerythritol Phosphate Route to Isoprenoids by Koppisch, Andrew T, Blagg, Brian S. J, Poulter, C. Dale

“…2-C-Methyl-d-erythritol 4-phosphate (4), formed from 1-deoxy-d-xylulose 5-phosphate (3), is the first pathway-specific intermediate in the methylerythritol…”
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