Search Results - "Blaesius, Rainer"

High accuracy gene expression profiling of sorted cell subpopulations from breast cancer PDX model tissue by Porter, Warren, Snowden, Eileen, Hahn, Friedrich, Ferguson, Mitchell, Tong, Frances, Dillmore, W. Shannon, Blaesius, Rainer

“…Intratumor Heterogeneity (ITH) is a functionally important property of tumor tissue and may be involved in drug resistance mechanisms. Although descriptions of…”
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Growth, differentiation capacity, and function of mesenchymal stem cells expanded in serum-free medium developed via combinatorial screening by Crapnell, Kirsten, Blaesius, Rainer, Hastings, Abel, Lennon, Donald P., Caplan, Arnold I., Bruder, Scott P.

“…The presence of serum in cell culture medium presents an obstacle to safe and efficient production of hMSCs for therapeutic purposes. Availability of defined…”
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Immunophenotyping and Transcriptomic Outcomes in PDX-Derived TNBC Tissue by Snowden, Eileen, Porter, Warren, Hahn, Friedrich, Ferguson, Mitchell, Tong, Frances, Parker, Joel S, Middlebrook, Aaron, Ghanekar, Smita, Dillmore, W Shannon, Blaesius, Rainer

“…Cancer tissue functions as an ecosystem of a diverse set of cells that interact in a complex tumor microenvironment. Genomic tools applied to biopsies in bulk…”
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Ex Vivo Drug Screening Informed Targeted Therapy for Metastatic Parotid Squamous Cell Carcinoma by Nykänen, Noora, Mäkelä, Rami, Arjonen, Antti, Härmä, Ville, Lewandowski, Laura, Snowden, Eileen, Blaesius, Rainer, Jantunen, Ismo, Kuopio, Teijo, Kononen, Juha, Rantala, Juha K.

“…The purpose of ex vivo drug screening in the context of precision oncology is to serve as a functional diagnostic method for therapy efficacy modeling directly…”
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Flow based single cell analysis of the immune landscape distinguishes Barrett's esophagus from adjacent normal tissue by Sen, Moen, Hahn, Friedrich, Black, Taylor A, DeMarshall, Maureen, Porter, Warren, Snowden, Eileen, Yee, Stephanie S, Tong, Frances, Ferguson, Mitchell, Fleshman, Emylee N, Nakagawa, Hiroshi, Falk, Gary W, Ginsberg, Gregory G, Kochman, Michael L, Blaesius, Rainer, Rustgi, Anil K, Carpenter, Erica L

“…Barrett's esophagus (BE) is metaplasia of the squamous epithelium to a specialized columnar epithelium. BE progresses through low- and high-grade dysplasia…”
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State-selective binding peptides for heterotrimeric G-protein subunits: novel tools for investigating G-protein signaling dynamics by Johnston, Christopher A, Willard, Francis S, Ramer, J Kevin, Blaesius, Rainer, Roques, C Natalia, Siderovski, David P

“…Heterotrimeric G-proteins, comprising Galpha, Gbeta, and Ggamma subunits, are molecular switches that regulate numerous signaling pathways involved in cellular…”
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Delineation of ligand binding and receptor signaling activities of purified P2Y receptors reconstituted with heterotrimeric G proteins by Bodor, Erik T, Waldo, Gary L, Blaesius, Rainer, Harden, T Kendall

“…P2Y receptors are G protein coupled receptors that respond to extracellular nucleotides to promote a multitude of signaling events. Our laboratory has purified…”
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Abstract 4710: Surface protein marker and single cell gene expression profiling of individual tumor cells dissociated from small cell lung cancer pdx mouse models can be correlated with in vivo sensitivity to the p70S6K/AKT1/3 inhibitor M2698 by Porter, Warren, Snowden, Eileen, Hahn, Friedrich, Ferguson, Mitchell, Tong, Frances, Dillmore, William S., Clark, Anderson, Zhang, Hong, Blaesius, Rainer

“…Abstract Small Cell Lung Cancer (SCLC) is characterized by rapid tumor growth and currently, there are few therapeutic options or predictive biomarkers…”
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Abstract 2000: Targeted characterization of tumor heterogeneity through RNA-Seq analysis of phenotypically defined subpopulations by Porter, Warren, Snowden, Eileen, Hahn, Friedrich, Ferguson, Mitchell, Tong, Frances, Dillmore, Shannon, Blaesius, Rainer

“…Abstract Cancer progression and metastases have been linked to the complex heterogeneity found within many solid tumors. In order to understand the…”
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Abstract 2197: Surface marker and gene expression profiling of tumors from PDX models of small cell lung cancer with varying sensitivity to growth inhibition by the p70S6K/AKT1/3 inhibitor M2698 by Hahn, Friedrich, Porter, Warren, Snowden, Eileen, Ferguson, Mitchell, Tong, Frances, Dillmore, William S., Clark, Anderson, Zhang, Hong, Blaesius, Rainer

“…Abstract Small Cell Lung Cancer (SCLC) is characterized by rapid tumor growth and currently, there are few therapeutic options. As part of the development of…”
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Abstract 2113: The effects of enzymatic digestion on epitope detection by flow cytometry by Middlebrook, Aaron J., Austin, Caitlin, Santos, Daniel, Snowden, Eileen, Porter, Warren, Hahn, Friedrich, Ferguson, Mitchell, Blaesius, Rainer, Ghanekar, Smita

“…Abstract The heterogeneous nature of solid tumors, coupled with the relatively small sample size of available biopsies, has led to an emerging need to glean as…”
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Abstract 2423: Deep phenotyping of dissociated solid tumor cells from breast cancer specimens by Middlebrook, Aaron J., Llontop, Peter, Hanley, Mary Beth, Porter, Warren, Hahn, Friedrich, Snowden, Eileen, Blaesius, Rainer, Ghanekar, Smita

“…Abstract Exploring tumor heterogeneity with the goal of improving outcome has led to the need to glean as much information as possible at an individual cell…”
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Abstract 1656: Comprehensive evaluation of human immune system reconstitution in NSGTM and NSGTM-SGM3 toward the development of a novel Onco-HuTM xenograft model by Middlebrook, Aaron J., Snowden, Eileen, Porter, Warren, Hahn, Friedrich, Ferguson, Mitchell, Soper, Brian, Keck, James, Malcolm, Joan, Dillmore, Shannon, Ghanekar, Smita, Blaesius, Rainer

“…Abstract The recent successes of immunotherapeutic approaches to the treatment of melanoma and the promise of similar treatments in a variety of other cancers…”
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Abstract 2391: Flow cytometric sorting of subpopulations followed by RNASeq reveals distinct phenotypes in PDX model of basal breast cancer by Porter, Warren, Hahn, Friedrich, Snowden, Eileen, Ferguson, Mitchell, Tong, Frances, Dillmore, Shannon, Parker, Joel S., Middlebrook, Aaron, Ghanekar, Smita, Blaesius, Rainer

“…Abstract The recognition of tumor tissue as an interactive ecosystem of distinct cell types has recently emerged as a very promising basis for more successful…”
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Abstract B11: Deep phenotyping of dissociated cells from PDX model solid tumors and human breast tumors using flow cytometry by Hahn, Friedrich, Snowden, Eileen, Porter, Warren, Ferguson, Mitchell, Dillmore, Shannon, Middlebrook, Aaron, Niknam, Shahryar, Llontop, Peter, Ghanekar, Smita, Blaesius, Rainer

“…Abstract The model of solid tumors as monolithic entities under the control of a handful of driver genes which seemed to dominate the general perception of…”
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Abstract 3949: Deep immunophenotyping using flow cytometry of dissociated cells from Barrett's esophagus and matched adjacent squamous epithelium defines distinct phenotypic clusters by Hahn, Friedrich G., Snowden, Eileen, Porter, Warren, Ferguson, Mitchell, Dillmore, William S., Yee, Stephanie S., Black, Taylor, DeMarshall, Maureen, Middlebrook, Aaron, Ghanekar, Smita, Rustgi, Anil, Carpenter, Erica L., Blaesius, Rainer

“…Abstract Barrett's esophagus (BE) is defined as metaplasia of the squamous epithelium to a specialized columnar epithelium with risk factors of…”
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Abstract B37: Phenotypic analysis of single cells dissociated from solid tumors by Ruitenberg, Joyce J., Middlebrook, Aaron, Suni, Maria, Hahn, Friedrich, Snowden, Eileen, Porter, Warren, Ferguson, Mitchell, Blaesius, Rainer, Ghanekar, Smita A.

“…Abstract Current methods for solid tumor analysis may be inadequate for addressing both the heterogeneity of tumor cells and the components of the tumor…”
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Abstract 227: Characterization of single cells from dissociated solid tumors by Middlebrook, Aaron J., Niknam, Shahryar, Ruitenberg, Joyce, Mach, Albert J., Suni, Maria, Porter, Warren, Hahn, Friedrich, Snowden, Eileen, Blaesius, Rainer, Ghanekar, Smita

“…Abstract The heterogeneous nature of solid tumors, coupled with the relatively small sample size of available biopsies, has led to an emerging need to glean as…”
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Abstract A38: Optimization of whole-genome amplification for analysis of single cells using next-generation sequencing by Amiss, Terry J., Tong, Frances, Snowden, Eileen, Kelly, Richard, Blaesius, Rainer, Herrmann, Nick, Hahn, Friedrich, Porter, Warren, Ferguson, Mitchell, Chang, Chen, Clancy, Daphne, Jurgensen, Stewart

“…Abstract The accurate analysis of both genotypic variation in tumors and tumor evolution due to selective pressure is important in determining treatment…”
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Correction: Flow based single cell analysis of the immune landscape distinguishes Barrett's esophagus from adjacent normal tissue by Sen, Moen, Hahn, Friedrich, Black, Taylor A, DeMarshall, Maureen, Porter, Warren, Snowden, Eileen, Yee, Stephanie S, Tong, Frances, Ferguson, Mitchell, Fleshman, Emylee N, Nakagawa, Hiroshi, Falk, Gary W, Ginsberg, Gregory G, Kochman, Michael L, Blaesius, Rainer, Rustgi, Anil K, Carpenter, Erica L

“…[This corrects the article DOI: 10.18632/oncotarget.26911.]…”
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