Search Results - "Blackwood, Erik A."

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis by Blackwood, Erik A., Azizi, Khalid, Thuerauf, Donna J., Paxman, Ryan J., Plate, Lars, Kelly, Jeffery W., Wiseman, R. Luke, Glembotski, Christopher C.

“…Pharmacologic activation of stress-responsive signaling pathways provides a promising approach for ameliorating imbalances in proteostasis associated with…”
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ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb by Blackwood, Erik A, Hofmann, Christoph, Santo Domingo, Michelle, Bilal, Alina S, Sarakki, Anup, Stauffer, Winston, Arrieta, Adrian, Thuerauf, Donna J, Kolkhorst, Fred W, Müller, Oliver J, Jakobi, Tobias, Dieterich, Christoph, Katus, Hugo A, Doroudgar, Shirin, Glembotski, Christopher C

“…RATIONALE:Endoplasmic reticulum (ER) stress dysregulates ER proteostasis, which activates the transcription factor, ATF6 (activating transcription factor 6α),…”
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Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins by Paxman, Ryan, Plate, Lars, Blackwood, Erik A, Glembotski, Chris, Powers, Evan T, Wiseman, R Luke, Kelly, Jeffery W

“…Pharmacologic arm-selective unfolded protein response (UPR) signaling pathway activation is emerging as a promising strategy to ameliorate imbalances in…”
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Dietary choline intake is necessary to prevent systems‐wide organ pathology and reduce Alzheimer's disease hallmarks by Dave, Nikhil, Judd, Jessica M., Decker, Annika, Winslow, Wendy, Sarette, Patrick, Villarreal Espinosa, Oscar, Tallino, Savannah, Bartholomew, Samantha K., Bilal, Alina, Sandler, Jessica, McDonough, Ian, Winstone, Joanna K., Blackwood, Erik A., Glembotski, Christopher, Karr, Timothy, Velazquez, Ramon

“…There is an urgent need to identify modifiable environmental risk factors that reduce the incidence of Alzheimer's disease (AD). The B‐like vitamin choline…”
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ATF6 as a Nodal Regulator of Proteostasis in the Heart by Glembotski, Christopher C, Arrieta, Adrian, Blackwood, Erik A, Stauffer, Winston T

“…Proteostasis encompasses a homeostatic cellular network in all cells that maintains the integrity of the proteome, which is critical for optimal cellular…”
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The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts by Stauffer, Winston T, Blackwood, Erik A, Azizi, Khalid, Kaufman, Randal J, Glembotski, Christopher C

“…Activating transcription factor-6 α (ATF6) is one of the three main sensors and effectors of the endoplasmic reticulum (ER) stress response and, as such, it is…”
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Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses via Transcriptional Regulation of the ER-Stress Master Regulator ATF6α by Stauffer, Winston T, Arrieta, Adrian, Blackwood, Erik A, Glembotski, Christopher C

“…There are more than 2000 transcription factors in eukaryotes, many of which are subject to complex mechanisms fine-tuning their activity and their…”
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Integrating ER and Mitochondrial Proteostasis in the Healthy and Diseased Heart by Arrieta, Adrian, Blackwood, Erik A, Stauffer, Winston T, Glembotski, Christopher C

“…The integrity of the proteome in cardiac myocytes is critical for robust heart function. Proteome integrity in all cells is managed by protein homeostasis or…”
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Designing Novel Therapies to Mend Broken Hearts: ATF6 and Cardiac Proteostasis by Blackwood, Erik A, Bilal, Alina S, Stauffer, Winston T, Arrieta, Adrian, Glembotski, Christopher C

“…The heart exhibits incredible plasticity in response to both environmental and genetic alterations that affect workload. Over the course of development, or in…”
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Modeling heart failure with preserved ejection fraction in female mice: an elusive target by Hale, Taben M, Blackwood, Erik A

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ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart by Jin, Jung-Kang, Blackwood, Erik A, Azizi, Khalid, Thuerauf, Donna J, Fahem, Asal G, Hofmann, Christoph, Kaufman, Randal J, Doroudgar, Shirin, Glembotski, Christopher C

“…RATIONALE:ER stress causes accumulation of misfolded proteins in the ER, activating the transcription factor, ATF6, which induces ER stress response genes…”
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Unfolding the Roles of Mitochondria as Therapeutic Targets for Heart Disease by Glembotski, Christopher C., Arrieta, Adrian, Blackwood, Erik A.

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The peroxisomal enzyme, FAR1, is induced during ER stress in an ATF6-dependent manner in cardiac myocytes by Marsh, Kayleigh G, Arrieta, Adrian, Thuerauf, Donna J, Blackwood, Erik A, MacDonnell, Lauren, Glembotski, Christopher C

“…Although peroxisomes have been extensively studied in other cell types, their presence and function have gone virtually unexamined in cardiac myocytes. Here,…”
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Optimizing Adeno-Associated Virus Serotype 9 for Studies of Cardiac Chamber–Specific Gene Regulation by Bilal, Alina S., Blackwood, Erik A., Thuerauf, Donna J., Glembotski, Christopher C.

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Mesencephalic astrocyte–derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart by Arrieta, Adrian, Blackwood, Erik A., Stauffer, Winston T., Santo Domingo, Michelle, Bilal, Alina S., Thuerauf, Donna J., Pentoney, Amber N., Aivati, Cathrine, Sarakki, Anup V., Doroudgar, Shirin, Glembotski, Christopher C.

“…We have previously demonstrated that ischemia/reperfusion (I/R) impairs endoplasmic reticulum (ER)-based protein folding in the heart and thereby activates an…”
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Design and Production of Heart Chamber-Specific AAV9 Vectors by Bilal, Alina S, Thuerauf, Donna J, Blackwood, Erik A, Glembotski, Christopher C

“…Adeno-associated virus serotype 9 (AAV9) is often used in heart research involving gene delivery due to its cardiotropism, high transduction efficiency, and…”
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ATF6 protects against protein misfolding during cardiac hypertrophy by Hofmann, Christoph, Aghajani, Marjan, Alcock, Cecily D., Blackwood, Erik A., Sandmann, Clara, Herzog, Nicole, Groß, Julia, Plate, Lars, Wiseman, R. Luke, Kaufman, Randal J., Katus, Hugo A., Jakobi, Tobias, Völkers, Mirko, Glembotski, Christopher C., Doroudgar, Shirin

“…Cardiomyocytes activate the unfolded protein response (UPR) transcription factor ATF6 during pressure overload-induced hypertrophic growth. The UPR is thought…”
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CaMKIIδ subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-κB and TNF-α by Gray, Charles B.B, Suetomi, Takeshi, Xiang, Sunny, Blackwood, Erik A, Glembotski, Christopher C, Miyamoto, Shigeki, Daan Westenbrink, B, Brown, Joan Heller

“…Abstract Deletion of Ca 2 +/ calmodulin-dependent protein kinase II delta (CaMKIIδ) has been shown to protect against in vivo ischemia/reperfusion (I/R)…”
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Noncanonical Form of ERAD Regulates Cardiac Hypertrophy by Blackwood, Erik A., MacDonnell, Lauren F., Thuerauf, Donna J., Bilal, Alina S., Murray, Victoria B., Bedi, Kenneth C., Margulies, Kenneth B., Glembotski, Christopher C.

“…Cardiac hypertrophy increases demands on protein folding, which causes an accumulation of misfolded proteins in the endoplasmic reticulum (ER). These misfolded…”
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ER-Specific Autophagy or ER-Phagy in Cardiac Myocytes Protects the Heart Against Doxorubicin-Induced Cardiotoxicity by Glembotski, Christopher C., Bagchi, Sukriti, Blackwood, Erik A.

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