Search Results - "Blackwood, Elizabeth M."

An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer by MCCLELAND, Mark L, ADLER, Adam S, BELVIN, Marcia, HATZIVASSILIOU, Georgia, BLACKWOOD, Elizabeth M, CORSON, Laura, EVANGELISTA, Marie, JIPING ZHA, FIRESTEIN, Ron, YONGLEI SHANG, HUNSAKER, Thomas, TRUONG, Tom, PETERSON, David, TORRES, Eric, LI LI, HALEY, Benjamin, STEPHAN, Jean-Philippe

“…Breast cancer has been redefined into three clinically relevant subclasses: (i) estrogen/progesterone receptor positive (ER+/PR+), (ii) HER2/ERRB2 positive,…”
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Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells by Ong, Christy C, Jubb, Adrian M, Haverty, Peter M, Zhou, Wei, Tran, Victoria, Truong, Tom, Turley, Helen, O'Brien, Tom, Vucic, Domagoj, Harris, Adrian L, Belvin, Marcia, Friedman, Lori S, Blackwood, Elizabeth M, Koeppen, Hartmut, Hoeflich, Klaus P

“…p21-activated kinases (PAKs) are serine/threonine protein kinases that serve as important mediators of Rac and Cdc42 GTPase function as well as pathways…”
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Lactate Dehydrogenase B Is Required for the Growth of KRAS-Dependent Lung Adenocarcinomas by MCCLELAND, Mark L, ADLER, Adam S, JACKSON, Erica, FORREST, William F, FIRESTEIN, Ron, DEMING, Laura, COSINO, Ely, LEE, Leslie, BLACKWOOD, Elizabeth M, SOLON, Margaret, TAO, Janet, LI LI, SHAMES, David

“…This study is aimed to identify genes within the KRAS genomic amplicon that are both coupregulated and essential for cell proliferation when KRAS is amplified…”
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An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth by Adler, Adam S, McCleland, Mark L, Yee, Sharon, Yaylaoglu, Murat, Hussain, Sofia, Cosino, Ely, Quinones, Gabriel, Modrusan, Zora, Seshagiri, Somasekar, Torres, Eric, Chopra, Vivek S, Haley, Benjamin, Zhang, Zemin, Blackwood, Elizabeth M, Singh, Mallika, Junttila, Melissa, Stephan, Jean-Philippe, Liu, Jinfeng, Pau, Gregoire, Fearon, Eric R, Jiang, Zhaoshi, Firestein, Ron

“…The spliceosome machinery is composed of multimeric protein complexes that generate a diverse repertoire of mRNA through coordinated splicing of heteronuclear…”
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CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency by Adler, Adam S, McCleland, Mark L, Truong, Tom, Lau, Shari, Modrusan, Zora, Soukup, Tim M, Roose-Girma, Merone, Blackwood, Elizabeth M, Firestein, Ron

“…CDK8 is a cyclin-dependent kinase that mediates transcriptional control of pathways linked to both cancer and stem cells. In this study, we show that CDK8 is…”
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Going the Distance: A Current View of Enhancer Action by Blackwood, Elizabeth M., Kadonaga, James T.

“…In eukaryotes, transcription of genes by RNA polymerase II yields messenger RNA intermediates from which protein products are synthesized. Transcriptional…”
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The Nck-Interacting Kinase Phosphorylates ERM Proteins for Formation of Lamellipodium by Growth Factors by Baumgartner, Martin, Sillman, Amy L., Blackwood, Elizabeth M., Srivastava, Jyoti, Madson, Nikki, Schilling, James W., Wright, Jocelyn H., Barber, Diane L.

“…The mammalian Ste20-like Nck-interacting kinase (NIK) and its orthologs Misshapen in Drosophila and Mig-15 in Caenorhabditis elegans have a conserved function…”
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Myc and Max proteins possess distinct transcriptional activities by Kretzner, Leo, Blackwood, Elizabeth M, Eisenman, Robert N

“…The Myc family proteins are thought to be involved in transcription because they have both a carboxy-terminal basic-helix-loop-helix-zipper (bHLH-Z) domain,…”
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Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors by Infante, Jeffrey R, Hollebecque, Antoine, Postel-Vinay, Sophie, Bauer, Todd M, Blackwood, Elizabeth M, Evangelista, Marie, Mahrus, Sami, Peale, Franklin V, Lu, Xuyang, Sahasranaman, Srikumar, Zhu, Rui, Chen, Yuan, Ding, Xiao, Murray, Elaine R, Schutzman, Jennifer L, Lauchle, Jennifer O, Soria, Jean-Charles, LoRusso, Patricia M

“…Chk1 inhibition potentiates DNA-damaging chemotherapy by overriding cell-cycle arrest and genome repair. This phase I study evaluated the Chk1 inhibitor…”
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Sequence-Specific DNA Binding by the c-Myc Protein by Blackwell, T. Keith, Kretzner, Leo, Blackwood, Elizabeth M., Eisenman, Robert N., Weintraub, Harold

“…While it has been known for some time that the c-Myc protein binds to random DNA sequences, no sequence-specific binding activity has been detected. At its…”
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P21-Activated Kinase 1 (PAK1) as a Therapeutic Target in BRAF Wild-Type Melanoma by ONG, Christy C, JUBB, Adrian M, HARRIS, Adrian L, FRIEDMAN, Lori S, BELVIN, Marcia, MIDDLETON, Mark R, BLACKWOOD, Elizabeth M, KOEPPEN, Hartmut, HOEFLICH, Klaus P, JAKUBIAK, Diana, WEI ZHOU, RUDOLPH, Joachim, HAVERTY, Peter M, KOWANETZ, Marcin, YIBING YAN, TREMAYNE, Jarrod, LISLE, Richard

“…Although remarkable clinical response rates in melanoma have been observed using vemurafenib or dabrafenib in patients with tumors carrying oncogenic mutations…”
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Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells by Koehler, Michael F. T, Bergeron, Philippe, Blackwood, Elizabeth M, Bowman, Krista, Clark, Kevin R, Firestein, Ron, Kiefer, James R, Maskos, Klaus, McCleland, Mark L, Orren, Linda, Salphati, Laurent, Schmidt, Steve, Schneider, Elisabeth V, Wu, Jiansheng, Beresini, Maureen H

“…Beginning with promiscuous COT inhibitors, which were found to inhibit CDK8, a series of 6-aza-benzothiophene containing compounds were developed into potent,…”
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Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8 by Bergeron, Philippe, Koehler, Michael F. T, Blackwood, Elizabeth M, Bowman, Krista, Clark, Kevin, Firestein, Ron, Kiefer, James R, Maskos, Klaus, McCleland, Mark L, Orren, Linda, Ramaswamy, Sreemathy, Salphati, Laurent, Schmidt, Steve, Schneider, Elisabeth V, Wu, Jiansheng, Beresini, Maureen

“…Using Sorafenib as a starting point, a series of potent and selective inhibitors of CDK8 was developed. When cocrystallized with CDK8 and cyclin C, these…”
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mTOR kinase inhibitor potentiates apoptosis of PI3K and MEK inhibitors in diagnostically defined subpopulations by Vijapurkar, Ulka, Robillard, Liliane, Zhou, Siqun, Degtyarev, Michael, Lin, Kui, Truong, Tom, Tremayne, Jarrod, Ross, Leanne Berry, Pei, Zhonghua, Friedman, Lori S, Blackwood, Elizabeth M, Belvin, Marcia

“…Highlights ► mTOR kinase inhibitors are cytostatic. ► Combination with PI3K inhibitors switches this response to cytotoxicity in PI3K mutant cell lines and…”
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Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc by Blackwood, Elizabeth M., Eisenman, Robert N.

“…The myc protooncogene family has been implicated in cell proliferation, differentiation, and neoplasia, but its mechanism of function at the molecular level is…”
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Myc and Max function as a nucleoprotein complex by Blackwood, E M, Kretzner, L, Eisenman, R N

“…The Myc family of oncoproteins are thought to regulate proliferation and differentiation in a wide variety of cell types. Recent studies show that Myc proteins…”
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CDK8 Maintains Tumor Dedififerentiation and Embryonic Stem Cell Pluripotency by ADLER, Adam S, MCCLELAND, Mark L, TRUONG, Tom, LAU, Shari, MODRUSAN, Zora, SOUKUP, Tim M, ROOSE-GIRMA, Merone, BLACKWOOD, Elizabeth M, FIRESTEIN, Ron

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Myc and Max associate in vivo by BLACKWOOD, E. M, LÜSCHER, B, EISENMAN, R. N

“…Max is a helix-loop-helix zipper protein that associates in vitro with Myc family proteins to form a sequence-specific DNA-binding complex. We show here, by…”
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Functional analysis of the AUG- and CUG-initiated forms of the c-Myc protein by Blackwood, E M, Lugo, T G, Kretzner, L, King, M W, Street, A J, Witte, O N, Eisenman, R N

“…Activation of the c-myc proto-oncogene by chromosomal translocation or proviral insertion frequently results in the separation of the c-myc coding region from…”
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Identification of protein-protein interactions by lambda gt11 expression cloning by Blackwood, E M, Eisenman, R N

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