Search Results - "Blackwell, Danielle J."
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PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity
Published in Cancer cell (13-09-2021)“…PARP7 is a monoPARP that catalyzes the transfer of single units of ADP-ribose onto substrates to change their function. Here, we identify PARP7 as a negative…”
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A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants
Published in Cell chemical biology (19-08-2021)“…PARP14 has been implicated by genetic knockout studies to promote protumor macrophage polarization and suppress the antitumor inflammatory response due to its…”
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Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule
Published in Chembiochem : a European journal of chemical biology (15-06-2021)“…PARP14 is an interferon‐stimulated gene that is overexpressed in multiple tumor types, influencing pro‐tumor macrophage polarization as well as suppressing the…”
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Abstract 48: RBN-2397: A potent and selective small molecule inhibitor of PARP7 that induces tumor-derived antitumor immunity dependent on CD8 T cells
Published in Cancer research (Chicago, Ill.) (01-07-2021)“…Abstract Targeting cytosolic nucleic acid sensing pathways and the Type I interferon (IFN) response is an emerging therapeutic strategy being explored in…”
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Abstract 1344: Small molecule inhibitor of CD38 modulates its intra- and extracellular functions leading to antitumor activity
Published in Cancer research (Chicago, Ill.) (01-07-2021)“…Abstract CD38 is an ADP-ribosyl cyclase that converts NAD+ to ADP-ribose (ADPR) or cyclic ADPR (cADPR) and nicotinamide. The enzyme can exist in either an…”
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Abstract 506: A bespoke screening platform to study mono(ADP-ribosylation)
Published in Cancer research (Chicago, Ill.) (15-08-2020)“…Abstract Mono(ADP-ribosylation) (MARylation) and poly(ADP-ribosylation) (PARylation) are post-translational modifications deposited on multiple amino acids by…”
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Abstract 3405: PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition leads to tumor regression
Published in Cancer research (Chicago, Ill.) (15-08-2020)“…Abstract Targeting cytosolic nucleic acid sensing pathways and the Type I interferon (IFN) response is an emerging therapeutic strategy being explored in…”
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Abstract DDT02-01: RBN-2397: A first-in-class PARP7 inhibitor targeting a newly discovered cancer vulnerability in stress-signaling pathways
Published in Cancer research (Chicago, Ill.) (15-08-2020)“…Abstract RBN-2397: A first-in-class PARP7 inhibitor targeting a newly discovered cancer vulnerability in stress-signaling pathways PARP7 is a monoPARP that…”
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Abstract 2154: PARP7 inhibitor RBN-2397 increases tumoral IFN signaling leading to various tumor cell intrinsic effects and tumor regressions in mouse models
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…Abstract Targeting cytosolic nucleic acid sensing pathways to activate the Type I interferon (IFN) response is an emerging therapeutic strategy being explored…”
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