Search Results - "Blacklock, Kristin"

Computational modeling of allosteric regulation in the hsp90 chaperones: a statistical ensemble analysis of protein structure networks and allosteric communications by Blacklock, Kristin, Verkhivker, Gennady M

“…A fundamental role of the Hsp90 chaperone in regulating functional activity of diverse protein clients is essential for the integrity of signaling networks. In…”
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Allosteric regulation of the Hsp90 dynamics and stability by client recruiter cochaperones: protein structure network modeling by Blacklock, Kristin, Verkhivker, Gennady M

“…The fundamental role of the Hsp90 chaperone in supporting functional activity of diverse protein clients is anchored by specific cochaperones. A family of…”
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Computational Design of a Photocontrolled Cytosine Deaminase by Blacklock, Kristin M, Yachnin, Brahm J, Woolley, G. Andrew, Khare, Sagar D

“…There is growing interest in designing spatiotemporal control over enzyme activities using noninvasive stimuli such as light. Here, we describe a…”
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Differential modulation of functional dynamics and allosteric interactions in the Hsp90-cochaperone complexes with p23 and Aha1: a computational study by Blacklock, Kristin, Verkhivker, Gennady M

“…Allosteric interactions of the molecular chaperone Hsp90 with a large cohort of cochaperones and client proteins allow for molecular communication and event…”
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A computational method for the design of nested proteins by loop‐directed domain insertion by Blacklock, Kristin M., Yang, Lu, Mulligan, Vikram K., Khare, Sagar D.

“…The computational design of novel nested proteins—in which the primary structure of one protein domain (insert) is flanked by the primary structure segments of…”
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Mathematical Models of Protease-Based Enzymatic Biosensors by Agrawal, Deepak K, Dolan, Elliott M, Hernandez, Nancy E, Blacklock, Kristin M, Khare, Sagar D, Sontag, Eduardo D

“…An important goal of synthetic biology is to build biosensors and circuits with well-defined input–output relationships that operate at speeds found in natural…”
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Computational assessment of thioether isosteres by Barrows, Robert D., Blacklock, Kristin M., Rablen, Paul R., Khare, Sagar D., Knapp, Spencer

“…•Diaryl and bis(heteroaryl) thioethers are important but metabolically vulnerable scaffolds in medicinal chemistry.•Calculations indicate that the bridging…”
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Photoswitchable Affinity Reagents: Computational Design and Efficient Red‐Light Switching by Yasuike, Nobuo, Blacklock, Kristin M., Lu, Huixin, Jaikaran, Anna S. I., McDonald, Sherin, Uppalapati, Maruti, Khare, Sagar D., Woolley, G. Andrew

“…Photo‐controlled affinity reagents seek to provide modular spatiotemporal control of bioactivity by conferring photo‐switchability of function on an affinity…”
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Structural bioinformatics and protein docking analysis of the molecular chaperone-kinase interactions: towards allosteric inhibition of protein kinases by targeting the hsp90-cdc37 chaperone machinery by Lawless, Nathan, Blacklock, Kristin, Berrigan, Elizabeth, Verkhivker, Gennady

“…A fundamental role of the Hsp90-Cdc37 chaperone system in mediating maturation of protein kinase clients and supporting kinase functional activity is essential…”
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Computational Modeling of Allosteric Regulation in the Hsp90 Chaperones: A Statistical Ensemble Analysis of Protein Structure Networks and Allosteric Communications: e1003679 by Blacklock, Kristin, Verkhivker, Gennady M

“…A fundamental role of the Hsp90 chaperone in regulating functional activity of diverse protein clients is essential for the integrity of signaling networks. In…”
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Experimentally Guided Structural Modeling and Dynamics Analysis of Hsp90–p53 Interactions: Allosteric Regulation of the Hsp90 Chaperone by a Client Protein by Blacklock, Kristin, Verkhivker, Gennady M

“…A fundamental role of the Hsp90 chaperone system in mediating maturation of protein clients is essential for the integrity of signaling pathways involved in…”
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Systematic Comparison of Amber and Rosetta Energy Functions for Protein Structure Evaluation by Rubenstein, Aliza B, Blacklock, Kristin, Nguyen, Hai, Case, David A, Khare, Sagar D

“…An accurate energy function is an essential component of biomolecular structural modeling and design. The comparison of differently derived energy functions…”
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Computational Design of a Photo-controlled Cytosine Deaminase by Blacklock, Kristin M., Yachnin, Brahm J., Woolley, G. Andrew, Khare, Sagar D.

“…There is growing interest in designing spatiotemporal control over enzyme activities using noninvasive stimuli such as light. Here, we describe a…”
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New Tools and Approaches for Computational Protein Design by Blacklock, Kristin Marie

“…This dissertation describes the development, benchmarking, validation, and application of computational methods, mostly written within the Rosetta suite of…”
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Allosteric Regulation of the Hsp90 Dynamics and Stability by Client Recruiter Cochaperones: Protein Structure Network Modeling: e86547 by Blacklock, Kristin, Verkhivker, Gennady M

“…The fundamental role of the Hsp90 chaperone in supporting functional activity of diverse protein clients is anchored by specific cochaperones. A family of…”
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