Search Results - "Blackledge, Charles W."

New Facile Method to Measure Cyanide in Blood by Blackledge, William C, Blackledge, Charles W, Griesel, Alexa, Mahon, Sari B, Brenner, Matthew, Pilz, Renate B, Boss, Gerry R

“…Cyanide, a well-known toxic substance that could be used as a weapon of mass destruction, is likely responsible for a substantial percentage of smoke…”
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Adsorption and photocatalytic degradation of human serum albumin on TiO2 and Ag–TiO2 films by Ahmed, Mukhtar H., Keyes, Tia E., Byrne, John. A., Blackledge, Charles W., Hamilton, Jeremy. W.

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Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors by Medina, Jesús R, Becker, Christopher J, Blackledge, Charles W, Duquenne, Celine, Feng, Yanhong, Grant, Seth W, Heerding, Dirk, Li, William H, Miller, William H, Romeril, Stuart P, Scherzer, Daryl, Shu, Arthur, Bobko, Mark A, Chadderton, Antony R, Dumble, Melissa, Gardiner, Christine M, Gilbert, Seth, Liu, Qi, Rabindran, Sridhar K, Sudakin, Valery, Xiang, Hong, Brady, Pat G, Campobasso, Nino, Ward, Paris, Axten, Jeffrey M

“…Phosphoinositide-dependent protein kinase-1(PDK1) is a master regulator of the AGC family of kinases and an integral component of the PI3K/AKT/mTOR pathway. As…”
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The discovery and structure–activity relationships of pyrano[3,4- b]indole based inhibitors of hepatitis C virus NS5B polymerase by LaPorte, Matthew G., Draper, Tandy L., Miller, Lori E., Blackledge, Charles W., Leister, Lara K., Amparo, Eugene, Hussey, Alison R., Young, Dorothy C., Chunduru, Srinivas K., Benetatos, Christopher A., Rhodes, Gerry, Gopalsamy, Ariamala, Herbertz, Torsten, Burns, Christopher J., Condon, Stephen M.

“…We describe the structure–activity relationship of the C1-group of pyrano[3,4- b]indole based inhibitors of HCV NS5B polymerase. Further exploration of the…”
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Silica nanoparticles containing a rhodamine dye and multiple gold nanorods by Blackledge, Charles W., Tabarin, Thibault, Masson, Emilie, Forster, Robert J., Keyes, Tia E.

“…Silica shells are grown around colloidally synthesized gold nanorods (AuNRs) to form core–shell particles (AuNR@SiO 2 ) of variable occupancy, defined as the…”
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Aminoindazole PDK1 Inhibitors: A Case Study in Fragment-Based Drug Discovery by Medina, Jesús R, Blackledge, Charles W, Heerding, Dirk A, Campobasso, Nino, Ward, Paris, Briand, Jacques, Wright, Lois, Axten, Jeffrey M

“…Fragment screening of phosphoinositide-dependent kinase-1 (PDK1) in a biochemical kinase assay afforded hits that were characterized and prioritized based on…”
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Acylprolinamides: A new class of peptide deformylase inhibitors with in vivo antibacterial activity by Axten, Jeffrey M., Medina, Jesús R., Blackledge, Charles W., Duquenne, Céline, Grant, Seth W., Bobko, Mark A., Peng, Tony, Miller, William H., Pinckney, Theresa, Gallagher, Timothy F., Kulkarni, Swarupa, Lewandowski, Thomas, Van Aller, Glenn S., Zonis, Rimma, Ward, Paris, Campobasso, Nino

“…A new class of PDF inhibitor with potent, broad spectrum antibacterial activity is described. Optimization of blood stability and potency provided compounds…”
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Two convenient regioselective syntheses of 1- N-alkyl-3-aryl-4-[pyrimidin-4-yl]-pyrazoles by Ralph, Jeffrey M., Faitg, Thomas H., Silva, Domingos J., Feng, Yanhong, Blackledge, Charles W., Adams, Jerry L.

“…Two regioselective synthetic routes for 1- N-alkyl-3-aryl-4-[pyrimidin-4-yl]-pyrazoles of generic formula 1 were developed. These highly efficient and scalable…”
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Benzyl 2-Cyano-3,3-Dimethyl-1-pyrrolidinecarboxylate, a Versatile Intermediate for the Synthesis of 3,3-Dimethylproline Derivatives by Medina, Jesus R, Blackledge, Charles W, Erhard, Karl F, Axten, Jeffrey M, Miller, William H

“…The synthesis of racemic nitrile (±)-9 was accomplished in four steps and 58% overall yield from the known pyrrolidinone 5. Nitrile (±)-9 was resolved via…”
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Zinc oxide nanorod growth on gold islands prepared by microsphere lithography on silicon and quartz by Blackledge, Charles W, Szarko, Jodi M, Dupont, Aurélie, Chan, George H, Read, Elizabeth L, Leone, Stephen R

“…Gold islands, vapor deposited on silicon and quartz by microsphere lithography patterning, are used to nucleate arrays of ZnO nanorods. ZnO is grown on…”
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Adsorption and photocatalytic degradation of human serum albumin on TiO 2 and Ag–TiO 2 films by Ahmed, Mukhtar H., Keyes, Tia E., Byrne, John. A., Blackledge, Charles W., Hamilton, Jeremy. W.

“…► TiO 2 synthesised and modified with Ag nano clusters. ► Adsorption study using Human serum albumin and Investigation of protein configuration via Raman,…”
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