Search Results - "Blackett, Piers R"

Vitamin D Status, Gender Differences, and Cardiometabolic Health Disparities by Sanghera, Dharambir K, Sapkota, Bishwa R, Aston, Christopher E, Blackett, Piers R

“…Vitamin D deficiency is an unrecognized epidemic found in India and also worldwide. Despite the high prevalence of diabetes among Indians, there is a paucity…”
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Assessing the prediction of type 2 diabetes risk using polygenic and clinical risk scores in South Asian study populations by Rout, Madhusmita, Wander, Gurpreet S., Ralhan, Sarju, Singh, Jai Rup, Aston, Christopher E., Blackett, Piers R., Chernausek, Steven, Sanghera, Dharambir K.

“…Background: Genome-wide polygenic risk scores (PRS) have shown high specificity and sensitivity in predicting type 2 diabetes (T2D) risk in Europeans. However,…”
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Genetic determinants of cardiometabolic risk: A proposed model for phenotype association and interaction by Blackett, Piers R., MD, Sanghera, Dharambir K., PhD

“…Abstract This review provides a translational and unifying summary of metabolic syndrome genetics and highlights evidence that genetic studies are starting to…”
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A Bidirectional Mendelian Randomization Study to evaluate the causal role of reduced blood vitamin D levels with type 2 diabetes risk in South Asians and Europeans by Bejar, Cynthia A, Goyal, Shiwali, Afzal, Shoaib, Mangino, Massimo, Zhou, Ang, van der Most, Peter J, Bao, Yanchun, Gupta, Vipin, Smart, Melissa C, Walia, Gagandeep K, Verweij, Niek, Power, Christine, Prabhakaran, Dorairaj, Singh, Jai Rup, Mehra, Narinder K, Wander, Gurpreet S, Ralhan, Sarju, Kinra, Sanjay, Kumari, Meena, de Borst, Martin H, Hyppönen, Elina, Spector, Tim D, Nordestgaard, Børge G, Blackett, Piers R, Sanghera, Dharambir K

“…Multiple observational studies have reported an inverse relationship between 25-hydroxyvitamin D concentrations (25(OH)D) and type 2 diabetes (T2D). However,…”
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Secondary hypertriglyceridemia in children and adolescents by Blackett, Piers R., MD, Wilson, Don P., MD, McNeal, Catherine J., MD, PhD

“…Abstract Secondary dyslipidemia with predominant hypertriglyceridemia may occur as a consequence of both common and rare causes. After accounting for obesity…”
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Ethnic differences in ApoC-III concentration and the risk of cardiovascular disease: No evidence for the cardioprotective role of rare/loss of function APOC3 variants in non-Europeans by Rout, Madhusmita, Lerner, Megan, Blackett, Piers R., Peyton, Marvin D., Stavrakis, Stavros, Sidorov, Evgeny, Sanghera, Dharambir K.

“…Hypertriglyceridemia is as an independent risk factor for cardiovascular disease (CVD). Apolipoprotein C-III (ApoC-III) is known to regulate triglyceride (TG)…”
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Vascular health in children and adolescents: effects of obesity and diabetes by Short, Kevin R, Blackett, Piers R, Gardner, Andrew W, Copeland, Kenneth C

“…The foundations for cardiovascular disease in adults are laid in childhood and accelerated by the presence of comorbid conditions, such as obesity, diabetes,…”
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Obesity genetics and cardiometabolic health: Potential for risk prediction by Sanghera, Dharambir K., Bejar, Cynthia, Sharma, Sonali, Gupta, Rajeev, Blackett, Piers R.

“…The increasing burden of obesity worldwide and its effect on cardiovascular disease (CVD) risk is an opportunity for evaluation of preventive approaches. Both…”
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Partial Defect in the Cholesterol Side-Chain Cleavage Enzyme P450scc (CYP11A1) Resembling Nonclassic Congenital Lipoid Adrenal Hyperplasia by Sahakitrungruang, Taninee, Tee, Meng Kian, Blackett, Piers R, Miller, Walter L

“…We describe the 8th and 9th patients with P450scc deficiency, and only the 2nd and 3rd with partial loss-of-function of P450scc. Context: The cholesterol…”
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A Case of 36-Year-Old Woman With Recurrent Hypoglycemia Due to Insulinoma With Cytokeratin-19 Expression: A Marker of Poor Prognosis by Jalilian, Respina, Mirza, Lubna, Blackett, Piers R

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Genome-wide association study of 25(OH) Vitamin D concentrations in Punjabi Sikhs: Results of the Asian Indian diabetic heart study by Sapkota, Bishwa R., Hopkins, Ruth, Bjonnes, Andrew, Ralhan, Sarju, Wander, Gurpreet S., Mehra, Narinder K., Singh, Jai Rup, Blackett, Piers R., Saxena, Richa, Sanghera, Dharambir K.

“…•First GWAS of South Asian population (Punjabi Sikh ancestry) for 25(OH) vitamin D level.•Identification of a novel locus near FOXA2/SSTR4 genes…”
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Sex Differences in Cardiovascular Disease Risk in Adolescents With Type 1 Diabetes by Krishnan, Sowmya, MD, Fields, David A., PhD, Copeland, Kenneth C., MD, Blackett, Piers R., MD, Anderson, Michael P., PhD, Gardner, Andrew W., PhD

“…Abstract Background Cardiovascular disease is seen at a younger age and at a higher prevalence in patients with type 1 diabetes than in the general population…”
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Sex differences in HDL ApoC-III in American Indian youth by Blackett, Piers R, Khan, Sohail, Wang, Wenyu, Alaupovic, Petar, Lee, Elisa T

“…Since American Indians are predisposed to type 2 diabetes (DM2) and associated cardiovascular risk, Cherokee boys and girls (n = 917) were studied to determine…”
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Association of APOE polymorphisms with diabetes and cardiometabolic risk factors and the role of APOE genotypes in response to anti-diabetic therapy: results from the AIDHS/SDS on a South Asian population by Sapkota, Bishwa, Subramanian, Anuradha, Priamvada, Gargi, Finely, Hadley, Blackett, Piers R, Aston, Christopher E, Sanghera, Dharambir K

“…Abstract Background and Objectives Apolipoprotein E ( APOE ) gene polymorphisms have been examined extensively in multiple global populations particularly due…”
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APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups by Goyal, Shiwali, Tanigawa, Yosuke, Zhang, Weihua, Chai, Jin-Fang, Almeida, Marcio, Sim, Xueling, Lerner, Megan, Chainakul, Juliane, Ramiu, Jonathan Garcia, Seraphin, Chanel, Apple, Blair, Vaughan, April, Muniu, James, Peralta, Juan, Lehman, Donna M, Ralhan, Sarju, Wander, Gurpreet S, Singh, Jai Rup, Mehra, Narinder K, Sidorov, Evgeny, Peyton, Marvin D, Blackett, Piers R, Curran, Joanne E, Tai, E Shyong, van Dam, Rob, Cheng, Ching-Yu, Duggirala, Ravindranath, Blangero, John, Chambers, John C, Sabanayagam, Charumathi, Kooner, Jaspal S, Rivas, Manuel A, Aston, Christopher E, Sanghera, Dharambir K

“…Hypertriglyceridemia has emerged as a critical coronary artery disease (CAD) risk factor. Rare loss-of-function (LoF) variants in apolipoprotein C-III have…”
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Two new unrelated cases of hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia resulting from the same novel nonsense mutation in the vitamin D receptor gene by Forghani, Nikta, Lum, Catherine, Krishnan, Sowmya, Wang, Jining, Wilson, Darrel M, Blackett, Piers R, Malloy, Peter J, Feldman, David

“…1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) an important regulator of bone homeostasis, mediates its actions by binding to the vitamin D receptor (VDR), a nuclear…”
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Proteinuric Nephropathy in Acquired and Congenital Generalized Lipodystrophy: Baseline Characteristics and Course during Recombinant Leptin Therapy by Javor, Edward D., Moran, Stephanie Ann, Young, Janice Ryan, Cochran, Elaine K., DePaoli, Alex M., Oral, Elif Arioglu, Turman, Martin A., Blackett, Piers R., Savage, David B., O’Rahilly, Stephen, Balow, James E., Gorden, Phillip

“…Generalized lipodystrophy is characterized by adipose tissue absence, hypoleptinemia, hypertriglyceridemia, insulin resistance, diabetes, hepatomegaly, and…”
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Body Mass Index and Apolipoproteins C-III, B, and A-I in Young Adult Cherokee by Blackett, Piers R., MB, ChB, Wang, Wenyu, PhD, Khan, Sohail, MB, BS, MPH, Lee, Elisa, PhD, Alaupovic, Petar, PhD

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Fatal Malignant Hyperthermia-Like Syndrome With Rhabdomyolysis Complicating the Presentation of Diabetes Mellitus in Adolescent Males by Hollander, Abby S, Olney, Robert C, Blackett, Piers R, Marshall, Bess A

“…This report describes a new fatal syndrome observed in adolescent males at the initial presentation of diabetes mellitus. The features include hyperglycemic…”
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Association of acanthosis nigricans with hyperinsulinemia compared with other selected risk factors for type 2 Diabetes in Cherokee indians the Cherokee Diabetes Study by STODDART, Martha L, BLEVINS, Kathleen S, LEE, Elisa T, WENYU WANG, BLACKETT, Piers R

“…To report prevalence rates of acanthosis nigricans (AN) and hyperinsulinemia and the association of AN with hyperinsulinemia compared with other known or…”
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