Search Results - "Blackburn, Thomas"

Depressive disorders: Treatment failures and poor prognosis over the last 50 years by Blackburn, Thomas P.

“…Depression like many diseases is pleiotropic but unlike cancer and Alzheimer's disease for example, is still largely stigmatized and falls into the dark…”
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The GABA system, a new target for medications against cognitive impairment—Associated with neuroactive steroids by Bäckström, Torbjörn, Turkmen, Sahruh, Das, Roshni, Doverskog, Magnus, Blackburn, Thomas P.

“…The prevalence of cognitive dysfunction, dementia, and neurodegenerative disorders such as Alzheimer's disease (AD) is increasing in parallel with an aging…”
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Allopregnanolone and its antagonist modulate neuroinflammation and neurological impairment by Bäckström, Torbjörn, Doverskog, Magnus, Blackburn, Thomas P., Scharschmidt, Bruce F., Felipo, Vicente

“…Neuroinflammation accompanies several brain disorders, either as a secondary consequence or as a primary cause and may contribute importantly to disease…”
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Optical Spectroscopy of Surfaces, Interfaces, and Thin Films by Blackburn, Thomas J, Tyler, Sarah M, Pemberton, Jeanne E

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Dominance of γ-γ electron-positron pair creation in a plasma driven by high-intensity lasers by He, Yutong, Blackburn, Thomas G., Toncian, Toma, Arefiev, Alexey V.

“…Creation of electrons and positrons from light alone is a basic prediction of quantum electrodynamics, but yet to be observed. Our simulations show that the…”
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Optical Spectroscopy of Surfaces, Interfaces, and Thin Films: A Status Report by Watts, Kristen E, Blackburn, Thomas J, Pemberton, Jeanne E

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Golexanolone reduces glial activation in the striatum and improves non-motor and some motor alterations in a rat model of Parkinson's disease by Izquierdo-Altarejos, Paula, Arenas, Yaiza M, Martínez-García, Mar, Vázquez, Lola, Mincheva, Gergana, Doverskog, Magnus, Blackburn, Thomas P, Bohnen, Nicolaas I, Llansola, Marta, Felipo, Vicente

“…Parkinson's disease (PD) affects more than 6 million people worldwide. Along with motor impairments, patients and animal models exhibiting PD symptoms also…”
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Golexanolone, a GABAA receptor modulating steroid antagonist, restores motor coordination and cognitive function in hyperammonemic rats by dual effects on peripheral inflammation and neuroinflammation by Mincheva, Gergana, Gimenez‐Garzo, Carla, Izquierdo‐Altarejos, Paula, Martinez‐Garcia, Mar, Doverskog, Magnus, Blackburn, Thomas P., Hällgren, Anneli, Bäckström, Torbjörn, Llansola, Marta, Felipo, Vicente

“…Aims Hyperammonemic rats show peripheral inflammation, increased GABAergic neurotransmission and neuroinflammation in cerebellum and hippocampus which induce…”
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Editorial overview: Preface to ‘a tribute to professor Norman Bowery’ by Blackburn, Thomas P, Trist, David G

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Towards ML-Based Diagnostics of Laser-Plasma Interactions by Rodimkov, Yury, Bhadoria, Shikha, Volokitin, Valentin, Efimenko, Evgeny, Polovinkin, Alexey, Blackburn, Thomas, Marklund, Mattias, Gonoskov, Arkady, Meyerov, Iosif

“…The power of machine learning (ML) in feature identification can be harnessed for determining quantities in experiments that are difficult to measure directly…”
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In memory of Norman Bowery (1944–2016) by Trist, David G, Kenakin, Terry P, Blackburn, Thomas P

“…•An article in memory of Professor Norman Bowery.•Norman Bowery discovered the GABAB receptor.•He identified the mechanism of action of Baclofen as a GABAB…”
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Neurological drug development: A guide for a start-up biotech by Blackburn, Thomas P., Dr, Bezard, Erwan, Dr

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Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist by Forray, Carlos, Borowsky, Beth, Durkin, Margaret M, Ogozalek, Kristine, Marzabadi, Mohammad R, DeLeon, John, Heurich, Rainer, Lichtblau, Harvey, Shaposhnik, Zoya, Daniewska, Irena, Blackburn, Thomas P, Branchek, Theresa A, Gerald, Christophe, Vaysse, Pierre J

“…Melanin concentrating hormone (MCH) is an orexigenic hypothalamic neuropeptide, which plays an important role in the complex regulation of energy balance and…”
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The promise of molecular science in brain health. What breakthroughs are anticipated in the next 20 years? by Hainsworth, Atticus H, Blackburn, Thomas P, Bradshaw, Elizabeth M, Elahi, Fanny M, Gorelick, Philip B, Isaacs, Jeremy D, Wallin, Anders, Williams, Steven CR

“…•In the past twenty years molecular science has delivered progress in therapeutic antibodies, biochemical markers, gene therapy and drug re-purposing.•Areas of…”
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Unforeseen advantage of looser focusing in vacuum laser acceleration by De Andres, Aitor, Bhadoria, Shikha, Marmolejo, Javier Tello, Muschet, Alexander, Fischer, Peter, Reza Barzegar, Hamid, Blackburn, Thomas, Gonoskov, Arkady, Hanstorp, Dag, Marklund, Mattias, Veisz, Laszlo

“…Acceleration of electrons in vacuum directly by intense laser fields holds great promise for the generation of high-charge, ultrashort, relativistic electron…”
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Anxiolytic- and Antidepressant-like Profiles of the Galanin-3 Receptor ($Gal_3$) Antagonists SNAP 37889 and SNAP 398299 by Chad J. Swanson, Thomas P. Blackburn, Xuexiang Zhang, Zheng, Kang, Xu, Zhi-Qing David, Hökfelt, Tomas, Toni D. Wolinsky, Michael J. Konkel, Heidi Chen, Huailing Zhong, Mary W. Walker, Craig, Douglas A., Christophe P. G. Gerald, Branchek, Theresa A.

“…The neuropeptide galanin mediates its effects through the receptor subtypes$Gal_1$,$Gal_2$, and$Gal_3$and has been implicated in anxiety-and depression-related…”
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A New Look At Some Old Data: The Nisenan Photographs of Alexander W. Chase by BLACKBURN, THOMAS C.

“…In 1877, Stephen Powers wrote an extended passage on the topic of money and wealth among Native Californians, and illustrated it by itemizing the treasured…”
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The medical benefit of 5-HT research by Jones, Brian J, Blackburn, Thomas P

“…5-HT research is now more than 50 years old, and it has generated a wealth of therapeutic agents, some of which have had a major impact on disease management…”
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Optimized Computation of Tight Focusing of Short Pulses Using Mapping to Periodic Space by Panova, Elena, Volokitin, Valentin, Efimenko, Evgeny, Ferri, Julien, Blackburn, Thomas, Marklund, Mattias, Muschet, Alexander, De Andres Gonzalez, Aitor, Fischer, Peter, Veisz, Laszlo, Meyerov, Iosif, Gonoskov, Arkady

“…When a pulsed, few-cycle electromagnetic wave is focused by optics with f-number smaller than two, the frequency components it contains are focused to…”
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Trace amine receptors as targets for novel therapeutics: legend, myth and fact by Branchek, Theresa A, Blackburn, Thomas P

“…Trace amines are attracting attention as neurotransmitters because they are believed to play a role in human disorders such as schizophrenia, depression,…”
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