Search Results - "Blackburn, Michael R."

STAT‐3 contributes to pulmonary fibrosis through epithelial injury and fibroblast‐myofibroblast differentiation by Pedroza, Mesias, Le, Thuy T., Lewis, Katherine, Karmouty‐Quintana, Harry, To, Sarah, George, Anuh T., Blackburn, Michael R., Tweardy, David J., Agarwal, Sandeep K.

“…ABSTRACT Lung fibrosis is the hallmark of the interstitial lung diseases. Alveolar epithelial cell (AEC) injury is akey step that contributes to a profibrotic…”
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MicroRNA-101 attenuates pulmonary fibrosis by inhibiting fibroblast proliferation and activation by Huang, Chaoqun, Xiao, Xiao, Yang, Ye, Mishra, Amorite, Liang, Yurong, Zeng, Xiangming, Yang, Xiaoyun, Xu, Dao, Blackburn, Michael R., Henke, Craig A., Liu, Lin

“…Aberrant proliferation and activation of lung fibroblasts contribute to the initiation and progression of idiopathic pulmonary fibrosis (IPF). However, the…”
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Comprehensive Characterization of Alternative Polyadenylation in Human Cancer by Xiang, Yu, Ye, Youqiong, Lou, Yanyan, Yang, Yang, Cai, Chunyan, Zhang, Zhao, Mills, Tingting, Chen, Ning-Yuan, Kim, Yoonjin, Muge Ozguc, Fatma, Diao, Lixia, Karmouty-Quintana, Harry, Xia, Yang, Kellems, Rodney E, Chen, Zheng, Blackburn, Michael R, Yoo, Seung-Hee, Shyu, Ann-Bin, Mills, Gordon B, Han, Leng

“…Alternative polyadenylation (APA) is emerging as a major post-transcriptional mechanism for gene regulation, and dysregulation of APA contributes to several…”
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Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury by Hoegl, Sandra, Brodsky, Kelley S, Blackburn, Michael R, Karmouty-Quintana, Harry, Zwissler, Bernhard, Eltzschig, Holger K

“…Acute lung injury (ALI) is an acute inflammatory lung disease that causes morbidity and mortality in critically ill patients. However, there are many instances…”
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Blockade of IL-6 Trans signaling attenuates pulmonary fibrosis by Le, Thanh-Thuy T, Karmouty-Quintana, Harry, Melicoff, Ernestina, Le, Thanh-Truc T, Weng, Tingting, Chen, Ning-Yuan, Pedroza, Mesias, Zhou, Yang, Davies, Jonathan, Philip, Kemly, Molina, Jose, Luo, Fayong, George, Anuh T, Garcia-Morales, Luis J, Bunge, Raquel R, Bruckner, Brian A, Loebe, Matthias, Seethamraju, Harish, Agarwal, Sandeep K, Blackburn, Michael R

“…Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease with progressive fibrosis and death within 2-3 y of diagnosis. IPF incidence and prevalence rates…”
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Adenosine and dopamine receptors coregulate photoreceptor coupling via gap junction phosphorylation in mouse retina by Li, Hongyan, Zhang, Zhijing, Blackburn, Michael R, Wang, Steven W, Ribelayga, Christophe P, O'Brien, John

“…Gap junctions in retinal photoreceptors suppress voltage noise and facilitate input of rod signals into the cone pathway during mesopic vision. These synapses…”
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Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells by Ryzhov, Sergey, Novitskiy, Sergey V, Goldstein, Anna E, Biktasova, Asel, Blackburn, Michael R, Biaggioni, Italo, Dikov, Mikhail M, Feoktistov, Igor

“…Extracellular adenosine and purine nucleotides are elevated in many pathological situations associated with the expansion of CD11b(+)Gr1(+) myeloid-derived…”
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The polymeric mucin Muc5ac is required for allergic airway hyperreactivity by Evans, Christopher M., Raclawska, Dorota S., Ttofali, Fani, Liptzin, Deborah R., Fletcher, Ashley A., Harper, Daniel N., McGing, Maggie A., McElwee, Melissa M., Williams, Olatunji W., Sanchez, Elizabeth, Roy, Michelle G., Kindrachuk, Kristen N., Wynn, Thomas A., Eltzschig, Holger K., Blackburn, Michael R., Tuvim, Michael J., Janssen, William J., Schwartz, David A., Dickey, Burton F.

“…In asthma, airflow obstruction is thought to result primarily from inflammation-triggered airway smooth muscle (ASM) contraction. However, anti-inflammatory…”
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Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease by Polosa, Riccardo, Blackburn, Michael R

“…Asthma and chronic obstructive pulmonary disease (COPD) are pulmonary disorders characterized by various degrees of inflammation and tissue remodeling…”
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Comprehensive characterization of circular RNAs in ~ 1000 human cancer cell lines by Ruan, Hang, Xiang, Yu, Ko, Junsuk, Li, Shengli, Jing, Ying, Zhu, Xiaoyu, Ye, Youqiong, Zhang, Zhao, Mills, Tingting, Feng, Jing, Liu, Chun-Jie, Jing, Ji, Cao, Jin, Zhou, Bingying, Wang, Li, Zhou, Yubin, Lin, Chunru, Guo, An-Yuan, Chen, Xi, Diao, Lixia, Li, Wenbo, Chen, Zhiao, He, Xianghuo, Mills, Gordon B, Blackburn, Michael R, Han, Leng

“…Human cancer cell lines are fundamental models for cancer research and therapeutic strategy development. However, there is no characterization of circular RNAs…”
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Interleukin 6 Underlies Angiotensin II–Induced Hypertension and Chronic Renal Damage by Zhang, Weiru, Wang, Wei, Yu, Hong, Zhang, Yujin, Dai, Yingbo, Ning, Chen, Tao, Lijian, Sun, Hong, Kellems, Rodney E, Blackburn, Michael R, Xia, Yang

“…Chronic kidney disease (CKD) is a prevalent life-threatening disease frequently associated with hypertension, progression to renal fibrosis, and eventual renal…”
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Loss of CD73-mediated actin polymerization promotes endometrial tumor progression by Bowser, Jessica L, Blackburn, Michael R, Shipley, Gregory L, Molina, Jose G, Dunner, Jr, Kenneth, Broaddus, Russell R

“…Ecto-5'-nucleotidase (CD73) is central to the generation of extracellular adenosine. Previous studies have highlighted a detrimental role for extracellular…”
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HIF1A up‐regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis by Philip, Kemly, Mills, Weng Tingting, Davies, Jonathan, Chen, Ning‐Yuan, Karmouty‐Quintana, Harry, Luo, Fayong, Molina, Jose G., Amione‐Guerra, Javier, Sinha, Neeraj, Guha, Ashrith, Eltzschig, Holger K., Blackburn, Michael R.

“…Idiopathic pulmonary fibrosis (IPF) is a deadly chronic lung disease. Extracellular accumulation of adenosine and subsequent activation of the ADORA2B receptor…”
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Adenosine receptors in regulation of dendritic cell differentiation and function by Novitskiy, Sergey V., Ryzhov, Sergey, Zaynagetdinov, Rinat, Goldstein, Anna E., Huang, Yuhui, Tikhomirov, Oleg Y., Blackburn, Michael R., Biaggioni, Italo, Carbone, David P., Feoktistov, Igor, Dikov, Mikhail M.

“…Differentiation of functional dendritic cells (DCs) critically depends on the microenvironment. DCs differentiate in hypoxic tumor sites and inflamed or…”
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Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury by Eckle, Tobias, Hughes, Kelly, Ehrentraut, Heidi, Brodsky, Kelley S., Rosenberger, Peter, Choi, Doo‐Sup, Ravid, Katya, Weng, Tingting, Xia, Yang, Blackburn, Michael R., Eltzschig, Holger K.

“…The signaling molecule adenosine has been implicated in attenuating acute lung injury (ALI). Adenosine signaling is terminated by its uptake through…”
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Alterations in adenosine metabolism and signaling in patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis by Zhou, Yang, Murthy, Jayasimha N, Zeng, Dewan, Belardinelli, Luiz, Blackburn, Michael R

“…Adenosine is generated in response to cellular stress and damage and is elevated in the lungs of patients with chronic lung disease. Adenosine signaling…”
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Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury by Pedroza, Mesias, Schneider, Daniel J, Karmouty-Quintana, Harry, Coote, Julie, Shaw, Stevan, Corrigan, Rebecca, Molina, Jose G, Alcorn, Joseph L, Galas, David, Gelinas, Richard, Blackburn, Michael R

“…Chronic lung diseases are the third leading cause of death in the United States due in part to an incomplete understanding of pathways that govern the…”
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Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis by Wirsdörfer, Florian, de Leve, Simone, Cappuccini, Federica, Eldh, Therese, Meyer, Alina V, Gau, Eva, Thompson, Linda F, Chen, Ning-Yuan, Karmouty-Quintana, Harry, Fischer, Ute, Kasper, Michael, Klein, Diana, Ritchey, Jerry W, Blackburn, Michael R, Westendorf, Astrid M, Stuschke, Martin, Jendrossek, Verena

“…Radiation-induced pulmonary fibrosis is a severe side effect of thoracic irradiation, but its pathogenesis remains poorly understood and no effective treatment…”
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Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia by Iriyama, Takayuki, Sun, Kaiqi, Parchim, Nicholas F, Li, Jessica, Zhao, Cheng, Song, Anren, Hart, Laura A, Blackwell, Sean C, Sibai, Baha M, Chan, Lee-Nien L, Chan, Teh-Sheng, Hicks, M John, Blackburn, Michael R, Kellems, Rodney E, Xia, Yang

“…Preeclampsia is a prevalent hypertensive disorder of pregnancy and a leading cause of maternal and neonatal morbidity and mortality worldwide. This pathogenic…”
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Detrimental effects of adenosine signaling in sickle cell disease by Xia, Yang, Zhang, Yujin, Dai, Yingbo, Wen, Jiaming, Zhang, Weiru, Grenz, Almut, Sun, Hong, Tao, Lijian, Lu, Guangxiu, Alexander, Danny C, Milburn, Michael V, Carter-Dawson, Louvenia, Lewis, Dorothy E, Zhang, Wenzheng, Eltzschig, Holger K, Kellems, Rodney E, Blackburn, Michael R, Juneja, Harinder S

“…Yujin Zhang et al . discovered that the concentration of adenosine in the blood is increased both in a mouse model of sickle cell disease and in humans with…”
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