Search Results - "Blackburn, Jonathan M."

Quantitative profiling of colorectal cancer-associated bacteria reveals associations between fusobacterium spp., enterotoxigenic Bacteroides fragilis (ETBF) and clinicopathological features of colorectal cancer by Viljoen, Katie S, Dakshinamurthy, Amirtha, Goldberg, Paul, Blackburn, Jonathan M

“…Various studies have presented clinical or in vitro evidence linking bacteria to colorectal cancer, but these bacteria have not previously been concurrently…”
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Advances in the development of human protein microarrays by Duarte, Jessica G, Blackburn, Jonathan M

“…High-content protein microarrays in principle enable the functional interrogation of the human proteome in a broad range of applications, including biomarker…”
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MetaNovo: An open-source pipeline for probabilistic peptide discovery in complex metaproteomic datasets by Potgieter, Matthys G, Nel, Andrew J M, Fortuin, Suereta, Garnett, Shaun, Wendoh, Jerome M, Tabb, David L, Mulder, Nicola J, Blackburn, Jonathan M

“…Microbiome research is providing important new insights into the metabolic interactions of complex microbial ecosystems involved in fields as diverse as the…”
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The Role of Tumor Microenvironment in Chemoresistance: 3D Extracellular Matrices as Accomplices by Senthebane, Dimakatso Alice, Jonker, Tina, Rowe, Arielle, Thomford, Nicholas Ekow, Munro, Daniella, Dandara, Collet, Wonkam, Ambroise, Govender, Dhirendra, Calder, Bridget, Soares, Nelson C, Blackburn, Jonathan M, Parker, M Iqbal, Dzobo, Kevin

“…The functional interplay between tumor cells and their adjacent stroma has been suggested to play crucial roles in the initiation and progression of tumors and…”
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Bacterially-Associated Transcriptional Remodelling in a Distinct Genomic Subtype of Colorectal Cancer Provides a Plausible Molecular Basis for Disease Development by Lennard, Katie S, Goosen, Ryan W, Blackburn, Jonathan M

“…The relevance of specific microbial colonisation to colorectal cancer (CRC) disease pathogenesis is increasingly recognised, but our understanding of possible…”
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Performance of the EUROIMMUN Anti-SARS-CoV-2 ELISA Assay for detection of IgA and IgG antibodies in South Africa by Gededzha, Maemu P, Mampeule, Nakampe, Jugwanth, Sarika, Zwane, Nontobeko, David, Anura, Burgers, Wendy A, Blackburn, Jonathan M, Grove, Jurette S, George, Jaya A, Sanne, Ian, Scott, Lesley, Stevens, Wendy, Mayne, Elizabeth S

“…Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) has been identified as the causative agent for causing the clinical syndrome of COVID -19…”
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Comparison between the proteome of Escherichia coli single colony and during liquid culture by Fortuin, Suereta, Nel, Andrew J.M., Blackburn, Jonathan M., Soares, Nelson C.

“…Most bacterial proteomic studies done to date utilise bacterial cells harvested from liquid culture media. However, it is widely accepted that many important…”
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Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette-Guérin followed by Ipilimumab in Patients with Advanced Metastatic Melanoma by Da Gama Duarte, Jessica, Parakh, Sagun, Andrews, Miles C, Woods, Katherine, Pasam, Anupama, Tutuka, Candani, Ostrouska, Simone, Blackburn, Jonathan M, Behren, Andreas, Cebon, Jonathan

“…Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced melanoma. The first ICI to demonstrate clinical benefit, ipilimumab, targets…”
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Performance of the Abbott SARS-CoV-2 IgG serological assay in South African 2 patients by Jugwanth, Sarika, Gededzha, Maemu P, Mampeule, Nakampe, Zwane, Nontobeko, David, Anura, Burgers, Wendy A, Blackburn, Jonathan M, Grove, Jurette S, George, Jaya A, Sanne, Ian, Scott, Lesley, Stevens, Wendy, Mayne, Elizabeth S

“…In late December 2019, pneumonia cases of unknown origin were reported in Wuhan, China. This virus was named SARS-CoV2 and the clinical syndrome was named…”
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B cells and antibody production in melanoma by Da Gama Duarte, Jessica, Peyper, Janique M., Blackburn, Jonathan M.

“…Recent developments in the immuno-oncology field strongly support a role for the immune system in both the prevention and progression of melanoma. Melanoma is…”
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A mass spectrometry-based approach for the identification of Kpnβ1 binding partners in cancer cells by Okpara, Michael O., Hermann, Clemens, van der Watt, Pauline J., Garnett, Shaun, Blackburn, Jonathan M., Leaner, Virna D.

“…Karyopherin beta 1 (Kpnβ1) is the principal nuclear importer of cargo proteins and plays a role in many cellular processes. Its expression is upregulated in…”
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Identification of potential autoantigens in anti-CCP-positive and anti-CCP-negative rheumatoid arthritis using citrulline-specific protein arrays by Poulsen, Thomas B. G., Damgaard, Dres, Jørgensen, Malene M., Senolt, Ladislav, Blackburn, Jonathan M., Nielsen, Claus H., Stensballe, Allan

“…The presence or absence of autoantibodies against citrullinated proteins (ACPAs) distinguishes two main groups of rheumatoid arthritis (RA) patients with…”
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Humoral immunoprofiling identifies novel biomarkers and an immune suppressive autoantibody phenotype at the site of disease in pancreatic ductal adenocarcinoma by Maimela, Pamela Winnie M, Smith, Muneerah, Nel, Andrew J M, Bernam, Suba Dharshanan P, Jonas, Eduard G, Blackburn, Jonathan M

“…Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous cancer, with minimal response to therapeutic intervention and with 85% of cases diagnosed at an…”
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Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression by Delgado-Diaz, David Jose, Jesaveluk, Brianna, Hayward, Joshua A, Tyssen, David, Alisoltani, Arghavan, Potgieter, Matthys, Bell, Liam, Ross, Elizabeth, Iranzadeh, Arash, Allali, Imane, Dabee, Smritee, Barnabas, Shaun, Gamieldien, Hoyam, Blackburn, Jonathan M, Mulder, Nicola, Smith, Steven B, Edwards, Vonetta L, Burgener, Adam D, Bekker, Linda-Gail, Ravel, Jacques, Passmore, Jo-Ann S, Masson, Lindi, Hearps, Anna C, Tachedjian, Gilda

“…Women with a cervicovaginal microbiota dominated by Lactobacillus spp. are at reduced risk of acquiring sexually transmitted infections including HIV, but the…”
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PMA: Protein Microarray Analyser, a user-friendly tool for data processing and normalization by Da Gama Duarte, Jessica, Goosen, Ryan W, Lawry, Peter J, Blackburn, Jonathan M

“…Protein microarrays provide a high-throughput platform to measure protein interactions and associated functions, and can aid in the discovery of cancer…”
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Multi-omics analysis of overexpressed tumor-associated proteins: gene expression, immunopeptide presentation, and antibody response in oropharyngeal squamous cell carcinoma, with a focus on cancer-testis antigens by Abou Kors, Tsima, Meier, Matthias, Mühlenbruch, Lena, Betzler, Annika C, Oliveri, Franziska, Bens, Martin, Thomas, Jaya, Kraus, Johann M, Doescher, Johannes, von Witzleben, Adrian, Hofmann, Linda, Ezic, Jasmin, Huber, Diana, Benckendorff, Julian, Barth, Thomas F E, Greve, Jens, Schuler, Patrick J, Brunner, Cornelia, Blackburn, Jonathan M, Hoffmann, Thomas K, Ottensmeier, Christian, Kestler, Hans A, Rammensee, Hans-Georg, Walz, Juliane S, Laban, Simon

“…The human leukocyte antigen complex (HLA) is essential for inducing specific immune responses to cancer by presenting tumor-associated peptides (TAP) to T…”
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Quantitative label-free proteomic analysis of human urine to identify novel candidate protein biomarkers for schistosomiasis by Onile, Olugbenga Samson, Calder, Bridget, Soares, Nelson C, Anumudu, Chiaka I, Blackburn, Jonathan M

“…Schistosomiasis is a chronic neglected tropical disease that is characterized by continued inflammatory challenges to the exposed population and it has been…”
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Epitope Coverage of Anti-SARS-CoV-2 Nucleocapsid IgA and IgG Antibodies Correlates with Protection against Re-Infection by New Variants in Subsequent Waves of the COVID-19 Pandemic by Mullins, Michelle O, Smith, Muneerah, Maboreke, Hazel, Nel, Andrew J M, Ntusi, Ntobeko A B, Burgers, Wendy A, Blackburn, Jonathan M

“…The COVID-19 pandemic continues to affect individuals across the globe, with some individuals experiencing more severe disease than others. The relatively high…”
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Longitudinal IgA and IgG Response, and ACE2 Binding Blockade, to Full-Length SARS-CoV-2 Spike Protein Variants in a Population of Black PLWH Vaccinated with ChAdOx1 nCoV-19 by Smith, Muneerah, Kwatra, Gaurav, Izu, Alane, Nel, Andrew, Cutland, Clare, Ahmed, Khatja, Baillie, Vicky, Barnabas, Shaun, Bhorat, Qasim, Briner, Carmen, Lazarus, Erica, Dheda, Keertan, Fairlie, Lee, Koen, Anthonet, Madhi, Shabir, Blackburn, Jonathan M

“…Vaccines against SARS-CoV-2 have been pivotal in overcoming the COVID-19 pandemic yet understanding the subsequent outcomes and immunological effects remain…”
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Longitudinal gut microbiota composition of South African and Nigerian infants in relation to tetanus vaccine responses by Iwase, Saori C, Osawe, Sophia, Happel, Anna-Ursula, Gray, Clive M, Holmes, Susan P, Blackburn, Jonathan M, Abimiku, Alash'le, Jaspan, Heather B

“…Infants who are exposed to HIV but uninfected (iHEU) have higher risk of infectious morbidity than infants who are HIV-unexposed and uninfected (iHUU),…”
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