Search Results - "Blackburn, Clare"

Thymic involution and rising disease incidence with age by Palmer, Sam, Albergante, Luca, Blackburn, Clare C., Newman, T. J.

“…For many cancer types, incidence rises rapidly with age as an apparent power law, supporting the idea that cancer is caused by a gradual accumulation of…”
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Regeneration of the aged thymus by a single transcription factor by Bredenkamp, Nicholas, Nowell, Craig S, Blackburn, C Clare

“…Thymic involution is central to the decline in immune system function that occurs with age. By regenerating the thymus, it may therefore be possible to improve…”
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FOXN1 in thymus organogenesis and development by Vaidya, Harsh Jayesh, Briones Leon, Alberto, Blackburn, C. Clare

“…Development of the primary T‐cell repertoire takes place in the thymus. The linked processes of T‐cell differentiation and T‐cell repertoire selection each…”
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Changes in primary lymphoid organs with aging by Chinn, Ivan K, Blackburn, Clare C, Manley, Nancy R, Sempowski, Gregory D

“…Highlights ► Hypoxic niches are critical for sustaining bone marrow stem cell lymphopoiesis. ► ROS and IL-6 accelerate bone marrow lymphoid senescence with…”
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Marketing of unproven stem cell-based interventions: A call to action by Sipp, Douglas, Caulfield, Timothy, Kaye, Jane, Barfoot, Jan, Blackburn, Clare, Chan, Sarah, De Luca, Michele, Kent, Alastair, McCabe, Christopher, Munsie, Megan, Sleeboom-Faulkner, Margaret, Sugarman, Jeremy, van Zimmeren, Esther, Zarzeczny, Amy, Rasko, John E J

“…Commercial promotion of unsupported therapeutic uses of stem cells is a global problem that has proven resistant to regulatory efforts. Here, we suggest a…”
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Prevalence of childhood disability and the characteristics and circumstances of disabled children in the UK: secondary analysis of the Family Resources Survey by Blackburn, Clare M, Spencer, Nick J, Read, Janet M

“…Robust data on the prevalence of childhood disability and the circumstances and characteristics of disabled children is crucial to understanding the…”
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Does socioeconomic position affect knowledge of the risk factors and warning signs of stroke in the WHO European region? A systematic literature review by Stack, Katie, Robertson, Wendy, Blackburn, Clare

“…Strokes are one of the leading causes of death worldwide. People with a lower socioeconomic position (SEP) (i.e. with regards to education, income and…”
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Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus by Ulyanchenko, Svetlana, O’Neill, Kathy E., Medley, Tanya, Farley, Alison M., Vaidya, Harsh J., Cook, Alistair M., Blair, Natalie F., Blackburn, C. Clare

“…Thymic epithelial cells (TECs) are critically required for T cell development, but the cellular mechanisms that maintain adult TECs are poorly understood…”
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Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence by Nowell, Craig S, Bredenkamp, Nicholas, Tetélin, Stéphanie, Jin, Xin, Tischner, Christin, Vaidya, Harsh, Sheridan, Julie M, Stenhouse, Frances Hogg, Heussen, Raphaela, Smith, Andrew J H, Blackburn, C Clare

“…The forkhead transcription factor Foxn1 is indispensable for thymus development, but the mechanisms by which it mediates thymic epithelial cell (TEC)…”
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Disabling chronic conditions in childhood and socioeconomic disadvantage: a systematic review and meta-analyses of observational studies by Spencer, Nicholas J, Blackburn, Clare M, Read, Janet M

“…ObjectiveTo determine the association of socioeconomic disadvantage with the prevalence of childhood disabling chronic conditions in high-income…”
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Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution by O'Neill, Kathy E, Bredenkamp, Nicholas, Tischner, Christin, Vaidya, Harsh J, Stenhouse, Frances H, Peddie, C Diana, Nowell, Craig S, Gaskell, Terri, Blackburn, C Clare

“…Thymus function requires extensive cross-talk between developing T-cells and the thymic epithelium, which consists of cortical and medullary TEC. The…”
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Dynamics of thymus organogenesis and colonization in early human development by Farley, Alison M, Morris, Lucy X, Vroegindeweij, Eric, Depreter, Marianne L G, Vaidya, Harsh, Stenhouse, Frances H, Tomlinson, Simon R, Anderson, Richard A, Cupedo, Tom, Cornelissen, Jan J, Blackburn, C Clare

“…The thymus is the central site of T-cell development and thus is of fundamental importance to the immune system, but little information exists regarding…”
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Where are you really from?’: a qualitative study of racial microaggressions and the impact on medical students in the UK by Morrison, Nariell, Zaman, Tabbasum, Webster, George, Sorinola, Olanrewaju, Blackburn, Clare

“…ObjectiveTo explore graduate-entry medical students’ experiences of racial microaggressions, the impact of these on learning, performance and attainment, and…”
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REPLY TO JIMÉNEZ-ALONSO ET AL., SCHOOLING AND ZHAO, AND MORTAZAVI: Further discussion on the immunological model of carcinogenesis by Palmer, Sam, Albergante, Luca, Blackburn, Clare C., Newman, T. J.

“…Palmer et al comments on the criticisms of their study exploring the relationship between thymic involution and rising disease incidence with age. There are…”
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Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development by Liu, Dong, Kousa, Anastasia I, O'Neill, Kathy E, Rouse, Paul, Popis, Martyna, Farley, Alison M, Tomlinson, Simon R, Ulyanchenko, Svetlana, Guillemot, Francois, Seymour, Philip A, Jørgensen, Mette C, Serup, Palle, Koch, Ute, Radtke, Freddy, Blackburn, C Clare

“…Thymus function depends on the epithelial compartment of the thymic stroma. Cortical thymic epithelial cells (cTECs) regulate T cell lineage commitment and…”
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IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis by Zepp, Jarod A, Zhao, Junjie, Liu, Caini, Bulek, Katazyna, Wu, Ling, Chen, Xing, Hao, Yujun, Wang, Zhenghe, Wang, Xinxin, Ouyang, Wenjun, Kalady, Matthew F, Carman, Julie, Yang, Wen-Pin, Zhu, Jun, Blackburn, Clare, Huang, Yina H, Hamilton, Thomas A, Su, Bing, Li, Xiaoxia

“…This study identifies a novel mechanism linking IL-17A with colon tissue repair and tumor development. Abrogation of IL-17A signaling in mice attenuated tissue…”
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Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression by Garfin, Phillip M, Min, Dullei, Bryson, Jerrod L, Serwold, Thomas, Edris, Badreddin, Blackburn, Clare C, Richie, Ellen R, Weinberg, Kenneth I, Manley, Nancy R, Sage, Julien, Viatour, Patrick

“…Thymic involution during aging is a major cause of decreased production of T cells and reduced immunity. Here we show that inactivation of Rb family genes in…”
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Thymic epithelial cell fate and potency in early organogenesis assessed by single cell transcriptional and functional analysis by Farley, Alison Mary, Chengrui, An, Palmer, Sam, Liu, Dong, Kousa, Anastasia I, Rouse, Paul, Major, Viktoria, Sweetman, Joanna, Morys, Jan, Corsinotti, Andrea, Nichols, Jennifer, Ure, Janice, McLay, Renee, Boulter, Luke, Chapman, S Jon, Tomlinson, Simon R, Blackburn, C Clare

“…During development, cortical (c) and medullary (m) thymic epithelial cells (TEC) arise from the third pharyngeal pouch endoderm. Current models suggest that…”
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Contribution of Neural Crest-Derived Cells in the Embryonic and Adult Thymus by Foster, Katie, Sheridan, Julie, Veiga-Fernandes, Henrique, Roderick, Kathleen, Pachnis, Vassilis, Adams, Ralf, Blackburn, Clare, Kioussis, Dimitris, Coles, Mark

“…Neural crest (NC)-derived mesenchyme has previously been shown to play an important role in the development of fetal thymus. Using Wnt1-Cre and Sox10-Cre mice…”
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Long-term persistence of functional thymic epithelial progenitor cells in vivo under conditions of low FOXN1 expression by Jin, Xin, Nowell, Craig S, Ulyanchenko, Svetlana, Stenhouse, Frances H, Blackburn, C Clare

“…Normal thymus function reflects interactions between developing T-cells and several thymic stroma cell types. Within the stroma, key functions reside in the…”
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