Search Results - "Black, Roy A"

Prebiotic amino acids bind to and stabilize prebiotic fatty acid membranes by Cornell, Caitlin E., Black, Roy A., Xue, Mengjun, Litz, Helen E., Ramsay, Andrew, Gordon, Moshe, Mileant, Alexander, Cohen, Zachary R., Williams, James A., Lee, Kelly K., Drobny, Gary P., Keller, Sarah L.

“…The membranes of the first protocells on the early Earth were likely self-assembled from fatty acids. A major challenge in understanding how protocells could…”
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Nucleobases bind to and stabilize aggregates of a prebiotic amphiphile, providing a viable mechanism for the emergence of protocells by Black, Roy A., Blosser, Matthew C., Stottrup, Benjamin L., Tavakley, Ravi, Deamer, David W., Keller, Sarah L.

“…Primordial cells presumably combined RNAs, which functioned as catalysts and carriers of genetic information, with an encapsulating membrane of aggregated…”
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Prebiotic Membranes and Micelles Do Not Inhibit Peptide Formation During Dehydration by Cohen, Zachary R., Kessenich, Brennan L., Hazra, Avijit, Nguyen, Julia, Johnson, Richard S., MacCoss, Michael J., Lalic, Gojko, Black, Roy A., Keller, Sarah L.

“…Cycles of dehydration and rehydration could have enabled formation of peptides and RNA in otherwise unfavorable conditions on the early Earth. Development of…”
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Local hydrogel release of recombinant TIMP-3 attenuates adverse left ventricular remodeling after experimental myocardial infarction by Eckhouse, Shaina R, Purcell, Brendan P, McGarvey, Jeremy R, Lobb, David, Logdon, Christina B, Doviak, Heather, O'Neill, Jason W, Shuman, James A, Novack, Craig P, Zellars, Kia N, Pettaway, Sara, Black, Roy A, Khakoo, Aarif, Lee, Taeweon, Mukherjee, Rupak, Gorman, Joseph H, Gorman, Robert C, Burdick, Jason A, Spinale, Francis G

“…An imbalance between matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) contributes to the left ventricle (LV) remodeling that occurs after…”
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A Self-Assembled Aggregate Composed of a Fatty Acid Membrane and the Building Blocks of Biological Polymers Provides a First Step in the Emergence of Protocells by Black, Roy A, Blosser, Matthew C

“…We propose that the first step in the origin of cellular life on Earth was the self-assembly of fatty acids with the building blocks of RNA and protein,…”
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ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23 by Blobel, Carl P, Weskamp, Gisela, Ford, Jill W, Sturgill, Jamie, Martin, Steve, Docherty, Andrew J P, Swendeman, Steven, Broadway, Neil, Hartmann, Dieter, Saftig, Paul, Umland, Shelby, Sehara-Fujisawa, Atsuko, Black, Roy A, Ludwig, Andreas, Becherer, J David, Conrad, Daniel H

“…CD23, the low-affinity immunoglobulin E receptor, is an important modulator of the allergic response and of diseases such as rheumatoid arthritis. The…”
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TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation by Doedens, John R, Mahimkar, Rajeev M, Black, Roy A

“…Tumor necrosis factor-α converting enzyme (TACE/ADAM-17) is a metalloprotease disintegrin that cleaves a variety of membrane proteins, releasing (“shedding”)…”
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TACE/ADAM17 Processing of EGFR Ligands Indicates a Role as a Physiological Convertase by LEE, DAVID C., SUNNARBORG, SUSAN WOHLER, HINKLE, C. LEANN, MYERS, TIMOTHY J., STEVENSON, MARY, RUSSELL, WILLIAM E., CASTNER, BEVERLY J., GERHART, MARY J., PAXTON, RAYMOND J., BLACK, ROY A., CHANG, AILEEN, JACKSON, LESLIE F.

“…: EGF family growth factors, including transforming growth factor‐alpha (TGFα), amphiregulin (AR), and heparin‐binding EGF (HB‐EGF), are invariably expressed…”
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Stabilization of Prebiotic Vesicles by Peptides Depends on Sequence and Chirality: A Mechanism for Selection of Protocell-Associated Peptides by Cohen, Zachary R., Todd, Zoe R., Maibaum, Lutz, Catling, David C., Black, Roy A.

“…Cells require oligonucleotides and polypeptides with specific, homochiral sequences to perform essential functions, but it is unclear how such oligomers were…”
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Growth of Prebiotically Plausible Fatty Acid Vesicles Proceeds in the Presence of Prebiotic Amino Acids, Dipeptides, Sugars, and Nucleic Acid Components by Todd, Zoe R., Cohen, Zachary R., Catling, David C., Keller, Sarah L., Black, Roy A.

“…Fatty acid vesicles may have played a role in the origin of life as a major structural component of protocells, with the potential for encapsulation of genetic…”
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Binding of Dipeptides to Fatty Acid Membranes Explains Their Colocalization in Protocells but Does Not Select for Them Relative to Unjoined Amino Acids by Xue, Mengjun, Black, Roy A, Cohen, Zachary R, Roehrich, Adrienne, Drobny, Gary P, Keller, Sarah L

“…Dipeptides, which consist of two amino acids joined by a peptide bond, have been shown to have catalytic functions. This observation leads to fundamental…”
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Prebiotic Protocell Membranes Retain Encapsulated Contents during Flocculation, and Phospholipids Preserve Encapsulation during Dehydration by Cohen, Zachary R, Cornell, Caitlin E, Catling, David C, Black, Roy A, Keller, Sarah L

“…The first cell membranes were likely composed of single-chain amphiphiles such as fatty acids. An open question is whether fatty acid membranes could have…”
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Tumor necrosis factor-α converting enzyme by Black, Roy A

“…Tumor necrosis factor-α converting enzyme (TACE/ADAM17/CD156q) is a member of the ‘A Disintegrin And Metalloprotease’, or ADAM, family. It is a multi-domain,…”
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Inactivation of Membrane Tumor Necrosis Factor Alpha by Gingipains from Porphyromonas gingivalis by Mężyk-Kopeć, Renata, Bzowska, Małgorzata, Potempa, Jan, Bzowska, Monika, Jura, Natalia, Sroka, Aneta, Black, Roy A, Bereta, Joanna

“…Gingipains are cysteine proteinases produced by Porphyromonas gingivalis, a major causative bacterium of adult periodontitis. They consist of arginine-specific…”
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A Step toward Molecular Evolution of RNA: Ribose Binds to Prebiotic Fatty Acid Membranes, and Nucleosides Bind Better than Individual Bases Do by Xue, Mengjun, Black, Roy A., Cornell, Caitlin E., Drobny, Gary P., Keller, Sarah L.

“…A major challenge in understanding how biological cells arose on the early Earth is explaining how RNA and membranes originally colocalized. We propose that…”
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Prebiotic Vesicles Retain Solutes and Grow by Micelle Addition after Brief Cooling below the Membrane Melting Temperature by Cohen, Zachary R., Todd, Zoe R., Catling, David C., Black, Roy A., Keller, Sarah L.

“…Replication of RNA genomes within membrane vesicles may have been a critical step in the development of protocells on the early Earth. Cold temperatures near 0…”
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A Proteomic Approach for the Identification of Cell-surface Proteins Shed by Metalloproteases by Guo, Lin, Eisenman, June R, Mahimkar, Rajeev M, Peschon, Jacques J, Paxton, Raymond J, Black, Roy A, Johnson, Richard S

“…Proteolytic cleavage (shedding) of extracellular domains of many membrane proteins by metalloproteases is an important regulatory mechanism used by mammalian…”
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Photic injury promotes cleavage of p75NTR by TACE and nuclear trafficking of the p75 intracellular domain by Srinivasan, Bhooma, Wang, Zhaohui, Brun-Zinkernagel, Anne M., Collier, Robert J., Black, Roy A., Frank, Stuart J., Barker, Philip A., Roque, Rouel S.

“…The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis factor receptor superfamily that paradoxically mediates neuronal survival and…”
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Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury by Roudier, Martine, Li, Xiaodong, Niu, Qing‐Tian, Pacheco, Efrain, Pretorius, James K., Graham, Kevin, Yoon, Bo‐Rin P., Gong, Jianhua, Warmington, Kelly, Ke, Hua Z., Black, Roy A., Hulme, Joanne, Babij, Philip

“…Objective Sclerostin plays a major role in regulating skeletal bone mass, but its effects in articular cartilage are not known. The purpose of this study was…”
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Plausible Sources of Membrane-Forming Fatty Acids on the Early Earth: A Review of the Literature and an Estimation of Amounts by Cohen, Zachary R., Todd, Zoe R., Wogan, Nicholas, Black, Roy A., Keller, Sarah L., Catling, David C.

“…The first cells were plausibly bounded by membranes assembled from fatty acids with at least 8 carbons. Although the presence of fatty acids on the early Earth…”
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