Search Results - "Black, Mark D."

Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia: latent inhibition studies in the rat by Black, Mark D., Varty, Geoffrey B., Arad, Michal, Barak, Segev, De Levie, Amaya, Boulay, Denis, Pichat, Philippe, Griebel, Guy, Weiner, Ina

“…Rationale SSR103800 and SSR504734 are novel glycine transport 1 (GlyT1) inhibitors with therapeutic potential for the treatment of schizophrenia. Objective The…”
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Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data by Black, Mark D

“…Positive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) modulators enhance glutamate transmission via the AMPA receptor by altering the rate…”
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The mGluR2 positive allosteric modulator, SAR218645, improves memory and attention deficits in translational models of cognitive symptoms associated with schizophrenia by Griebel, Guy, Pichat, Philippe, Boulay, Denis, Naimoli, Vanessa, Potestio, Lisa, Featherstone, Robert, Sahni, Sukhveen, Defex, Henry, Desvignes, Christophe, Slowinski, Franck, Vigé, Xavier, Bergis, Olivier E., Sher, Rosy, Kosley, Raymond, Kongsamut, Sathapana, Black, Mark D., Varty, Geoffrey B.

“…Normalization of altered glutamate neurotransmission through activation of the mGluR2 has emerged as a new approach to treat schizophrenia. These studies…”
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Pro-Cognitive and Antipsychotic Efficacy of the α7 Nicotinic Partial Agonist SSR180711 in Pharmacological and Neurodevelopmental Latent Inhibition Models of Schizophrenia by Barak, Segev, Arad, Michal, De Levie, Amaya, Black, Mark D, Griebel, Guy, Weiner, Ina

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AVE1625, a cannabinoid CB1 receptor antagonist, as a co-treatment with antipsychotics for schizophrenia: improvement in cognitive function and reduction of antipsychotic-side effects in rodents by Black, Mark D., Stevens, Rachel J., Rogacki, Nancy, Featherstone, Robert E., Senyah, Yaw, Giardino, Odessa, Borowsky, Beth, Stemmelin, Jeanne, Cohen, Caroline, Pichat, Philippe, Arad, Michal, Barak, Segev, De Levie, Amaya, Weiner, Ina, Griebel, Guy, Varty, Geoffrey B.

“…Rationale The psychotomimetic effects of cannabis are believed to be mediated via cannabinoid CB1 receptors. Furthermore, studies have implicated CB1 receptors…”
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An electrophysiological model of spinal transmission deficits in mouse experimental autoimmune encephalomyelitis by Hanak, Susan E, Reilly, Erin M, Wotanis, Jill, Zhu, Bin, Pulicicchio, Claudine, McMonagle-Strucko, Kathleen, Wettstein, Joseph G, Black, Mark D

“…Chronic relapsing/remitting experimental autoimmune encephalomyelitis (EAE) can be induced in 8-week-old female SJL/J(H-2) mice via inoculation with the…”
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Comparative analysis of acute and chronic administration of haloperidol and clozapine using [ 3H] 2-deoxyglucose metabolic mapping by Wotanis, Jill, Hanak, Susan E., Wettstein, Joseph G., Black, Mark D.

“…In an effort to compare and contrast the mechanisms of action of typical and atypical antipsychotic drugs, [ 3H] 2-deoxyglucose metabolic mapping was employed…”
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The acoustic startle reflex in Sprague-Dawley rats is altered by permanent middle cerebral artery occlusion by Maynard, Kenneth I., Sukoff, Stacey J., Ji, Zhongqi, Wettstein, Joseph G., Black, Mark D.

“…The startle reflex is an unconditioned, quantifiable behavior used to study sensory modalities. We examined whether the acoustic startle reflex (ASR) was…”
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Therapeutic potential of positive ampa modulators and their relationship to AMPA receptor subunits. A review of preclinical data: Glutamate Receptor Subtypes: Promising New Pharmacotherapeutic Targets by BLACK, Mark D

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Pro-Cognitive and Antipsychotic Efficacy of the 7 Nicotinic Partial Agonist SSR180711 in Pharmacological and Neurodevelopmental Latent Inhibition Models of Schizophrenia by Barak, Segev, Arad, Michal, De Levie, Amaya, Black, Mark D, Griebel, Guy, Weiner, Ina

“…Schizophrenia symptoms can be segregated into positive, negative and cognitive, which exhibit differential sensitivity to drug treatments. Accumulating…”
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Pro-Cognitive and Antipsychotic Efficacy of the α7 Nicotinic Partial Agonist SSRI807II in Pharmacological and Neurodevelopmental Latent Inhibition Models of Schizophrenia by BARAK, Segev, ARAD, Michal, DE LEVIE, Amaya, BLACK, Mark D, GRIEBEL, Guy, WEINER, Ina

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Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia : latent inhibition studies in the rat: Special Issue on Cognitive Enhancers by BLACK, Mark D, VARTY, Geoffrey B, ARAD, Michal, BARAK, Segev, DE LEVIE, Amaya, BOULAY, Denis, PICHAT, Philippe, GRIEBEL, Guy, WEINER, Ina

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On the effect of neonatal nitric oxide synthase inhibition in rats: a potential neurodevelopmental model of schizophrenia by Black, Mark D., Selk, David E., Hitchcock, J.M., Wettstein, Joseph G., Sorensen, Stephen M.

“…NADPH-d (nicotinamide-adenine dinucleotide phosphate-diaphorase) neurons are thought to migrate improperly during development in the brains of schizophrenic…”
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Pro-cognitive and antipsychotic efficacy of the alpha7 nicotinic partial agonist SSR180711 in pharmacological and neurodevelopmental latent inhibition models of schizophrenia by Barak, Segev, Arad, Michal, De Levie, Amaya, Black, Mark D, Griebel, Guy, Weiner, Ina

“…Schizophrenia symptoms can be segregated into positive, negative and cognitive, which exhibit differential sensitivity to drug treatments. Accumulating…”
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Evidence that nitric oxide causes calcium-independent release of [3H] dopamine from rat striatum in vitro by Stewart, T L, Michel, A D, Black, M D, Humphrey, P P

“…Nitric oxide (NO), liberated from the photoactive donor Roussin's black salt (RBS), was investigated for its ability to release tritium from…”
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Effect of AMPA receptor modulators on hippocampal and cortical function by Black, Mark D., Wotanis, Jill, Schilp, Donald E., Hanak, Susan E., Sorensen, Stephen M., Wettstein, Joseph G.

“…Attention has focused on drugs that modulate AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid) receptors because of their potential for enhancing…”
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Neonatal hippocampal lesion model of schizophrenia in rats: Sex differences and persistence of effects into maturity by Black, Mark D., Lister, Sarah, Hitchcock, Janice M., Giersbergen, Paul Van, Sorensen, Stephen M.

“…A neurodevelopmental model of schizophrenia in rats has recently been proposed employing neonatal hippocampal lesions. The present study further characterizes…”
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Changes in dopamine D1 and D2 receptor binding in the substantia nigra following intrastriatal injection of a retrograde neurotoxin (volkensin) by Black, M D, Crossman, A R

“…The neurotoxic properties of the proposed retrograde neurotoxin volkensin were investigated. Unilateral intrastriatal injections of volkensin (n = 8) caused a…”
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Effects of glycine antagonists in an acute in vitro electrophysiological model of ischemia by Schilp, Donald E., Sorensen, Stephen M., Wettstein, Joseph G., Black, Mark D.

“…The effects of several glycine antagonists at the strychnine‐insensitive site on N‐methyl‐D‐aspartate (NMDA) receptors in an acute in vitro…”
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Receptor Populations on Striatal Efferents. Implications for Huntington's Disease by Black, Mark D

“…Evidence has suggested that the N-methyl-D-aspartate (NMDA) receptor plays a pivotal role in the sequential degeneration of striatal efferents seen in…”
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