Search Results - "Black, Lauren D."

Electrical and mechanical stimulation of cardiac cells and tissue constructs by Stoppel, Whitney L., Kaplan, David L., Black, Lauren D.

“…The field of cardiac tissue engineering has made significant strides over the last few decades, highlighted by the development of human cell derived constructs…”
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3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors by Sood, Disha, Tang-Schomer, Min, Pouli, Dimitra, Mizzoni, Craig, Raia, Nicole, Tai, Albert, Arkun, Knarik, Wu, Julian, Black, Lauren D., Scheffler, Bjorn, Georgakoudi, Irene, Steindler, Dennis A., Kaplan, David L.

“…Dynamic alterations in the unique brain extracellular matrix (ECM) are involved in malignant brain tumors. Yet studies of brain ECM roles in tumor cell…”
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Clinical Applications of Naturally Derived Biopolymer-Based Scaffolds for Regenerative Medicine by Stoppel, Whitney L., Ghezzi, Chiara E., McNamara, Stephanie L., III, Lauren D. Black, Kaplan, David L.

“…Naturally derived polymeric biomaterials, such as collagens, silks, elastins, alginates, and fibrins are utilized in tissue engineering due to their…”
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In vitro and in vivo analysis of visible light crosslinkable gelatin methacryloyl (GelMA) hydrogels by Noshadi, Iman, Hong, Seonki, Sullivan, Kelly E, Shirzaei Sani, Ehsan, Portillo-Lara, Roberto, Tamayol, Ali, Shin, Su Ryon, Gao, Albert E, Stoppel, Whitney L, Black, III, Lauren D, Khademhosseini, Ali, Annabi, Nasim

“…Photocrosslinkable materials have been frequently used for constructing soft and biomimetic hydrogels for tissue engineering. Although ultraviolet (UV) light…”
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A FRESH SLATE for 3D bioprinting by Dasgupta, Queeny, Black, 3rd, Lauren D

“…Greater structural complexity has been achieved in additive manufacturing of biomaterials Additive manufacturing (more commonly called three-dimensional or 3D…”
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Lysyl oxidase enzymes mediate TGF-β1-induced fibrotic phenotypes in human skin-like tissues by Huang, Mengqi, Liu, Zhiyi, Baugh, Lauren, DeFuria, Jason, Maione, Anna, Smith, Avi, Kashpur, Olga, Black III, Lauren D., Georgakoudi, Irene, Whitfield, Michael L., Garlick, Jonathan

“…Cutaneous fibrosis is a common complication seen in mixed connective tissue diseases. It often occurs as a result of TGF-β-induced deposition of excessive…”
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Elastic, silk-cardiac extracellular matrix hydrogels exhibit time-dependent stiffening that modulates cardiac fibroblast response by Stoppel, Whitney L., Gao, Albert E., Greaney, Allison M., Partlow, Benjamin P., Bretherton, Ross C., Kaplan, David L., Black III, Lauren D.

“…Heart failure is the leading cause of death in the United States and rapidly becoming the leading cause of death worldwide. While pharmacological treatments…”
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Evaluation of rapid transepithelial electrical resistance (TEER) measurement as a metric of kidney toxicity in a high-throughput microfluidic culture system by Shaughnessey, Erin M., Kann, Samuel H., Azizgolshani, Hesham, Black, Lauren D., Charest, Joseph L., Vedula, Else M.

“…Rapid non-invasive kidney-specific readouts are essential to maximizing the potential of microfluidic tissue culture platforms for drug-induced nephrotoxicity…”
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Stimuli-responsive composite biopolymer actuators with selective spatial deformation behavior by Wang, Yushu, Huang, Wenwen, Wang, Yu, Mu, Xuan, Ling, Shengjie, Yu, Haipeng, Chen, Wenshuai, Guo, Chengchen, Watson, Matthew C., Yu, Yingjie, Black, Lauren D., Li, Meng, Omenetto, Fiorenzo G., Li, Chunmei, Kaplan, David L.

“…Bioinspired actuators with stimuli-responsive and deformable properties are being pursued in fields such as artificial tissues, medical devices and…”
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Cell-induced alignment augments twitch force in fibrin gel-based engineered myocardium via gap junction modification by Black, 3rd, Lauren D, Meyers, Jason D, Weinbaum, Justin S, Shvelidze, Yevgeniya A, Tranquillo, Robert T

“…A high-potential therapy for repairing the heart post-myocardial infarction is the implantation of tissue-engineered myocardium. While several groups have…”
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Functional maturation of human neural stem cells in a 3D bioengineered brain model enriched with fetal brain-derived matrix by Sood, Disha, Cairns, Dana M., Dabbi, Jayanth M., Ramakrishnan, Charu, Deisseroth, Karl, Black, Lauren D., Santaniello, Sabato, Kaplan, David L.

“…Brain extracellular matrix (ECM) is often overlooked in vitro brain tissue models, despite its instructive roles during development. Using developmental…”
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Anisotropic silk biomaterials containing cardiac extracellular matrix for cardiac tissue engineering by Stoppel, Whitney L, Hu, Dongjian, Domian, Ibrahim J, Kaplan, David L, Black, 3rd, Lauren D

“…Cardiac malformations and disease are the leading causes of death in the United States in live-born infants and adults, respectively. In both of these cases, a…”
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Fetal Brain Extracellular Matrix Boosts Neuronal Network Formation in 3D Bioengineered Model of Cortical Brain Tissue by Sood, Disha, Chwalek, Karolina, Stuntz, Emily, Pouli, Dimitra, Du, Chuang, Tang-Schomer, Min, Georgakoudi, Irene, Black, Lauren D, Kaplan, David L

“…The extracellular matrix (ECM) constituting up to 20% of the organ volume is a significant component of the brain due to its instructive role in the…”
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Cardiac Fibroblasts Support Endothelial Cell Proliferation and Sprout Formation but not the Development of Multicellular Sprouts in a Fibrin Gel Co-Culture Model by Twardowski, Rachel L., Black, Lauren D.

“…A primary impediment to cardiac tissue engineering lies in the inability to adequately vascularize the constructs to optimize survival upon implantation…”
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Cardiac extracellular matrix–fibrin hybrid scaffolds with tunable properties for cardiovascular tissue engineering by Williams, Corin, Budina, Erica, Stoppel, Whitney L., Sullivan, Kelly E., Emani, Sirisha, Emani, Sitaram M., Black, Lauren D.

“…[Display omitted] Solubilized cardiac extracellular matrix (ECM) is being developed as an injectable therapeutic that offers promise for promoting cardiac…”
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RNA sequencing indicates age-dependent shifts in the cardiac fibroblast transcriptome between fetal, neonatal, and adult developmental ages by Perreault, Luke R, Le, Thanh T, Oudin, Madeleine J, Black, 3rd, Lauren D

“…Cardiac fibroblasts are responsible for extracellular matrix turnover and repair in the cardiac environment and serve to help facilitate immune responses…”
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Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis Through Lysyl Oxidase–like 4: New Evidence From Three‐Dimensional Skin‐like Tissues by Huang, Mengqi, Cai, Guoshuai, Baugh, Lauren M., Liu, Zhiyi, Smith, Avi, Watson, Matthew, Popovich, Dillon, Zhang, Tianyue, Stawski, Lukasz S., Trojanowska, Maria, Georgakoudi, Irene, Black, Lauren D., Pioli, Patricia A., Whitfield, Michael L., Garlick, Jonathan

“…Objective Systemic sclerosis (SSc) is a clinically heterogeneous disease characterized by increased collagen accumulation and skin stiffness. Our previous work…”
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Self‐Assembled Human Skin Equivalents Model Macrophage Activation of Cutaneous Fibrogenesis in Systemic Sclerosis by Huang, Mengqi, Smith, Avi, Watson, Matthew, Bhandari, Rajan, Baugh, Lauren M., Ivanovska, Irena, Watkins, Trishawna, Lang, Irene, Trojanowska, Maria, Black, Lauren D., Pioli, Patricia A., Garlick, Jonathan, Whitfield, Michael L.

“…Objective The development of precision therapeutics for systemic sclerosis (SSc) has been hindered by the lack of models that accurately mimic the disease in…”
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Right Ventricular Outflow Tract Surgical Resection in Young, Large Animal Model for the Study of Alternative Cardiovascular Patches by Porter, Elizabeth C, Stoppel, Whitney L, Kudej, Raymond K, Black, 3rd, Lauren D

“…Tetralogy of Fallot (ToF) is a severe congenital heart defect (CHD) that requires surgical reconstruction soon after birth. Reconstructive surgery involves the…”
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Partially Digested Adult Cardiac Extracellular Matrix Promotes Cardiomyocyte Proliferation In Vitro by Williams, Corin, Sullivan, Kelly, Black III, Lauren D.

“…Stimulating or maintaining the proliferative capacity of postnatal mammalian cardiomyocytes is a major challenge to cardiac regeneration. Previously, it is…”
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