Search Results - "Black, Chelsea M."

Impact of gene molecular evolution on phylogenetic reconstruction: a case study in the rosids (Superorder Rosanae, Angiosperms) by Hilu, Khidir W, Black, Chelsea M, Oza, Dipan

“…Rate of substitution of genomic regions is among the most debated intrinsic features that impact phylogenetic informativeness. However, this variable is also…”
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Trafficking of high avidity HER-2/neu-specific T cells into HER-2/neu-expressing tumors after depletion of effector/memory-like regulatory T cells by Weiss, Vivian L, Lee, Timothy H, Song, Hong, Kouo, Theodore S, Black, Chelsea M, Sgouros, George, Jaffee, Elizabeth M, Armstrong, Todd D

“…Cancer vaccines are designed to activate and enhance cancer-antigen-targeted T cells that are suppressed through multiple mechanisms of immune tolerance in…”
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Human ABCB6 Localizes to Both the Outer Mitochondrial Membrane and the Plasma Membrane by Paterson, Jill K, Shukla, Suneet, Black, Chelsea M, Tachiwada, Tokushi, Garfield, Susan, Wincovitch, Stephen, Ernst, David N, Agadir, Anissa, Li, Xuelin, Ambudkar, Suresh V, Szakacs, Gergely, Akiyama, Shin-ichi, Gottesman, Michael M

“…Expression of the ATP-binding cassette transporter ABCB6 has been associated with multiple cellular functions, including resistance to several cytotoxic…”
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MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential by Tigue, Natalie J., Bamber, Lisa, Andrews, John, Ireland, Samantha, Hair, James, Carter, Edward, Sridharan, Sudharsan, Jovanović, Jelena, Rees, D. Gareth, Springall, Jeremy S., Solier, Emilie, Li, Yi-Ming, Chodorge, Matthieu, Perez-Martinez, David, Higazi, Daniel R., Oberst, Michael, Kennedy, Maureen, Black, Chelsea M., Yan, Li, Schwickart, Martin, Maguire, Shaun, Cann, Jennifer A., de Haan, Lolke, Young, Lesley L., Vaughan, Tristan, Wilkinson, Robert W., Stewart, Ross

“…Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) is part of a system of signals involved in controlling T-cell activation…”
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Apoptosis-regulated low-avidity cancer-specific CD8(+) T cells can be rescued to eliminate HER2/neu-expressing tumors by costimulatory agonists in tolerized mice by Black, Chelsea M, Armstrong, Todd D, Jaffee, Elizabeth M

“…A major barrier to vaccines in cancer treatment is their failure to activate and maintain a complete cancer-specific CD8(+) effector T-cell repertoire…”
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Nondominant CD8 T cells are active players in the vaccine-induced antitumor immune response by Uram, Jennifer N, Black, Chelsea M, Flynn, Emilee, Huang, Lanqing, Armstrong, Todd D, Jaffee, Elizabeth M

“…We previously reported that CD8(+) T cells are directed predominantly toward the immunodominant Her-2/neu (neu) epitope RNEU(420-429) in nontolerized FVB/N but…”
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Abstract 455: Pro-apoptotic proteins affect survival of tumor-specific low avidity CD8+ T cells in tolerant mice by Black, Chelsea M., Jaffee, Elizabeth M., Armstrong, Todd D.

“…Abstract A major barrier to cancer vaccines as therapy is the many tolerance mechanisms inhibiting the activation of cancer-specific T cells. Higher avidity T…”
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Abstract B54: Low avidity tumor-specific CD8+ T cells are regulated by increased expression of proapoptotic proteins in tolerant mice by Black, Chelsea M., Armstrong, Todd D., Jaffee, Elizabeth M.

“…Abstract This study aimed to identify potential tolerance signals specific to lower avidity T cells. Cancer vaccines are currently being investigated as a way…”
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Preventing peripheral deletion enables apopstosis-susceptible, neu-specific, low avidity T cells to traffic into the tumor by Black, Chelsea M

“…A major barrier to the effectiveness of cancer vaccines is the inability of tumor-specific low avidity T cells to traffic into and eradicate tumors. Low…”
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