Search Results - "Blömeke, Brunhilde"

Endothelial responses of the alveolar barrier in vitro in a dose-controlled exposure to diesel exhaust particulate matter by Klein, Sebastian G, Cambier, Sébastien, Hennen, Jennifer, Legay, Sylvain, Serchi, Tommaso, Nelissen, Inge, Chary, Aline, Moschini, Elisa, Krein, Andreas, Blömeke, Brunhilde, Gutleb, Arno C

“…During the last 250 years, the level of exposure to combustion-derived particles raised dramatically in western countries, leading to increased particle loads…”
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Extrahepatic metabolism at the body's internal-external interfaces by Gundert-Remy, Ursula, Bernauer, Ulrike, Blömeke, Brunhilde, Döring, Barbara, Fabian, Eric, Goebel, Carsten, Hessel, Stefanie, Jäckh, Christine, Lampen, Alfonso, Oesch, Franz, Petzinger, Ernst, Völkel, Wolfgang, Roos, Peter H.

“…Abstract In general, xenobiotic metabolizing enzymes (XMEs) are expressed in lower levels in the extrahepatic tissues than in the liver, making the former less…”
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Impact of aryl hydrocarbon receptor (AhR) knockdown on cell cycle progression in human HaCaT keratinocytes by Kalmes, Michaela, Hennen, Jenny, Clemens, Judith, Blömeke, Brunhilde

“…Abstract While activation of the aryl hydrocarbon receptor (AhR) by exogenous ligands is well investigated, its physiological function is less understood. By…”
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The role of the antioxidant ascorbic acid in the elicitation of contact allergic reactions to p-phenylenediamine by Coenraads, Pieter-Jan, Vogel, Tatiana A., Blömeke, Brunhilde, Goebel, Carsten, Roggeband, Robert, Schuttelaar, M.L.A.

“…Summary Background An allergic contact reaction is accompanied by high oxidative stress in the skin. Pretreatment of the skin with antioxidative substances…”
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State-of-the-art and new options to assess T cell activation by skin sensitizers: Cosmetics Europe Workshop by van Vliet, Erwin, Kühnl, Jochen, Goebel, Carsten, Martinozzi-Teissier, Silvia, Alépée, Nathalie, Ashikaga, Takao, Blömeke, Brunhilde, Del Bufalo, Aurelia, Cluzel, Magalie, Corsini, Emanuela, Delrue, Nathalie, Desprez, Bertrand, Gellatly, Nichola, Giese, Christoph, Gribaldo, Laura, Hoffmann, Sebastian, Klaric, Martina, Maillere, Bernard, Naisbitt, Dean, Pallardy, Marc, Vocanson, Marc, Petersohn, Dirk

“…Significant progress has been made in the development and validation of non-animal test methods for skin sensitization assessment. At present, three of the…”
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Determination of p-phenylenediamine and its metabolites MAPPD and DAPPD in biological samples using HPLC-DAD and amperometric detection by Meyer, Axel, Blömeke, Brunhilde, Fischer, Klaus

“…A sensitive and selective HPLC method using a diode array detector (DAD) and an electrochemical detector (ECD) in series has been developed and validated for…”
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Cryobanking of viable biomaterials: implementation of new strategies for conservation purposes by Lermen, Dominik, Blomeke, Brunhilde, Browne, Robert, Clarke, Ann, Dyce, Paul W, Fixemer, Thomas, Fuhr, Gunter R, Holt, William V, Jewgenow, Katarina, Lloyd, Rhiannon E, Lotters, Stefan, Paulus, Martin, Reid, Gordon McGregor, Rapoport, Daniel H, Rawson, David, Ringleb, Jennifer, Ryder, Oliver A, Sporl, Gabriele, Schmitt, Thomas, Veith, Michael, Muller, Paul

“…Cryobanking, the freezing of biological specimens to maintain their integrity for a variety of anticipated and unanticipated uses, offers unique opportunities…”
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Quantitative risk assessment for skin sensitisation: Consideration of a simplified approach for hair dye ingredients by Goebel, Carsten, Diepgen, Thomas L., Krasteva, Maya, Schlatter, Harald, Nicolas, Jean-Francois, Blömeke, Brunhilde, Coenraads, Pieter Jan, Schnuch, Axel, Taylor, James S., Pungier, Jacquemine, Fautz, Rolf, Fuchs, Anne, Schuh, Werner, Gerberick, G. Frank, Kimber, Ian

“…► Introduction of quantitative-risk-assessment for skin sensitization by hair dyes. ► Measured-exposure-level (MEL) concept applied to determine hair dyeing…”
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An improved 3D tetraculture system mimicking the cellular organisation at the alveolar barrier to study the potential toxic effects of particles on the lung by Klein, Sebastian G, Serchi, Tommaso, Hoffmann, Lucien, Blömeke, Brunhilde, Gutleb, Arno C

“…Exposure to fine and ultra-fine ambient particles is still a problem of concern in many industrialised parts of the world and the intensified use of…”
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p53 and K-ras mutations in lung cancers from former and never-smoking women by VÄHÄKANGAS, Kirsi H, BENNETT, William P, CASTREN, Katariina, WELSH, Judith A, KHAN, Mohammed A, BLÖMEKE, Brunhilde, ALAVANJA, Michael C. R, HARRIS, Curtis C

“…Somatic p53 mutations are common in lung cancer. Active cigarette smoking is positively correlated with the total frequency of p53 mutations and G:C to T:A…”
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Assessment of skin sensitization potency of hair dye molecules in vitro by Hennen, Jennifer, Blömeke, Brunhilde

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Sequence Variations in Subjects with Self-Reported Multiple Chemical Sensitivity (sMCS): A Case-Control Study by Wiesmüller, Gerhard A., Niggemann, Hiltrud, Weißbach, Wibke, Riley, Felix, Maarouf, Zackaria, Dott, Wolfgang, Kunert, Hanns-Jürgen, Zerres, Klaus, Eggermann, Thomas, Blömeke, Brunhilde

“…Polymorphisms in several genes contribute to interindividual differences in the metabolism of xenobiotics, and may lead to toxicity and disease. The balance…”
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Keratinocytes improve prediction of sensitization potential and potency of chemicals with THP-1 cells by Hennen, Jennifer, Blömeke, Brunhilde

“…In vitro approaches to address key steps of chemical-induced skin sensitization have been developed, but there is uncertainty how keratinocytes, which play a…”
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Lighttyper assay with locked-nucleic-acid-modified oligomers for genotyping of the toll-like receptor 4 polymorphisms A896G and C1196T by GRANNEMANN, Silke, LANDT, Olfert, BREUER, Sebastian, BLÖMEKE, Brunhilde

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Verbesserte Aktivierung und Detektion von Prohaptenen in einer Ko-Kultur by Hennen, Jennifer, Blömeke, Brunhilde

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An in vitro coculture system for the detection of sensitization following aerosol exposure by Chary, Aline, Serchi, Tommaso, Moschini, Elisa, Hennen, Jennifer, Cambier, Sebastien, Ezendam, Janine, Blömeke, Brunhilde, Gutleb, Arno C

“…The aim of the study was to develop an in vitro model that mimics the alveolar-capillary barrier and that allows assessment of the respiratory sensitizing…”
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Activation and deactivation of aromatic amine hair dyes in the skin by Blömeke, Brunhilde

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Tolerability and Cross-reactivity of 3 New Hair Colorants in p-Phenylenediamine-Allergic Individuals by Koch, Lukas, Plaschg, Karin, Fuchs, Anne, Wood, Jonathan, Fautz, Rolf, Kränke, Birger, Aberer, Werner, Blömeke, Brunhilde

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N-Acetyltransferase 1 in Colon and Rectal Cancer Cases from an Industrialized Area by Roemer, Hermann C., Weistenhöfer, Wobbeke, Löhlein, Dietrich, Geller, Frank, Blömeke, Brunhilde, Golka, Klaus

“…Colon and rectal cancers are both associated with genetic as well as nutritional, occupational, and environmental factors. Aromatic amines and heterocyclic…”
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Introduction of a methoxymethyl side chain into p-phenylenediamine attenuates its sensitizing potency and reduces the risk of allergy induction by Goebel, Carsten, Troutman, John, Hennen, Jenny, Rothe, Helga, Schlatter, Harald, Gerberick, G. Frank, Blömeke, Brunhilde

“…The strong sensitizing potencies of the most important primary intermediates of oxidative hair dyes, p-phenylenediamine (PPD) and p-toluylenediamine (PTD, i.e…”
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