Search Results - "Bjorkman, Pamela J."

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization by Klein, Florian, Diskin, Ron, Scheid, Johannes F., Gaebler, Christian, Mouquet, Hugo, Georgiev, Ivelin S., Pancera, Marie, Zhou, Tongqing, Incesu, Reha-Baris, Fu, Brooks Zhongzheng, Gnanapragasam, Priyanthi N.P., Oliveira, Thiago Y., Seaman, Michael S., Kwong, Peter D., Bjorkman, Pamela J., Nussenzweig, Michel C.

“…Broadly neutralizing antibodies (bNAbs) to HIV-1 can prevent infection and are therefore of great importance for HIV-1 vaccine design. Notably, bNAbs…”
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Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy by West, Anthony P., Scharf, Louise, Scheid, Johannes F., Klein, Florian, Bjorkman, Pamela J., Nussenzweig, Michel C.

“…Despite 30 years of effort, there is no effective vaccine for HIV-1. However, antibodies can prevent HIV-1 infection in humanized mice and macaques when…”
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SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies by Barnes, Christopher O., Jette, Claudia A., Abernathy, Morgan E., Dam, Kim-Marie A., Esswein, Shannon R., Gristick, Harry B., Malyutin, Andrey G., Sharaf, Naima G., Huey-Tubman, Kathryn E., Lee, Yu E., Robbiani, Davide F., Nussenzweig, Michel C., West, Anthony P., Bjorkman, Pamela J.

“…The coronavirus disease 2019 (COVID-19) pandemic presents an urgent health crisis. Human neutralizing antibodies that target the host ACE2 receptor-binding…”
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Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice by Cohen, Alexander A, Gnanapragasam, Priyanthi N P, Lee, Yu E, Hoffman, Pauline R, Ou, Susan, Kakutani, Leesa M, Keeffe, Jennifer R, Wu, Hung-Jen, Howarth, Mark, West, Anthony P, Barnes, Christopher O, Nussenzweig, Michel C, Bjorkman, Pamela J

“…Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-related emergent zoonotic coronaviruses is urgently needed. We made…”
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Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies by Greaney, Allison J., Starr, Tyler N., Barnes, Christopher O., Weisblum, Yiska, Schmidt, Fabian, Caskey, Marina, Gaebler, Christian, Cho, Alice, Agudelo, Marianna, Finkin, Shlomo, Wang, Zijun, Poston, Daniel, Muecksch, Frauke, Hatziioannou, Theodora, Bieniasz, Paul D., Robbiani, Davide F., Nussenzweig, Michel C., Bjorkman, Pamela J., Bloom, Jesse D.

“…Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals previously infected with SARS-CoV-2, but the relative contributions…”
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Broadly Neutralizing Antibody 8ANC195 Recognizes Closed and Open States of HIV-1 Env by Scharf, Louise, Wang, Haoqing, Gao, Han, Chen, Songye, McDowall, Alasdair W., Bjorkman, Pamela J.

“…The HIV-1 envelope (Env) spike contains limited epitopes for broadly neutralizing antibodies (bNAbs); thus, most neutralizing antibodies are strain specific…”
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Partially Open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion by Wang, Haoqing, Barnes, Christopher O., Yang, Zhi, Nussenzweig, Michel C., Bjorkman, Pamela J.

“…HIV-1 Env, a trimer of gp120-gp41 heterodimers, mediates membrane fusion after binding host receptor CD4. Receptor binding displaces V1V2 loops from Env's…”
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Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120 by West, Anthony P, Diskin, Ron, Nussenzweig, Michel C, Bjorkman, Pamela J

“…A large number of anti–HIV-1 antibodies targeting the CD4-binding site (CD4bs) on the envelope glycoprotein gp120 have recently been reported. These…”
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LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells by Gu, Mingyu, LaJoie, Dollie, Chen, Opal S., von Appen, Alexander, Ladinsky, Mark S., Redd, Michael J., Nikolova, Linda, Bjorkman, Pamela J., Sundquist, Wesley I., Ullman, Katharine S., Frost, Adam

“…Endosomal sorting complexes required for transport III (ESCRT-III) proteins have been implicated in sealing the nuclear envelope in mammals, spindle pole body…”
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Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high-resolution intact circuit mapping and phenotyping by Treweek, Jennifer B, Chan, Ken Y, Flytzanis, Nicholas C, Yang, Bin, Deverman, Benjamin E, Greenbaum, Alon, Lignell, Antti, Xiao, Cheng, Cai, Long, Ladinsky, Mark S, Bjorkman, Pamela J, Fowlkes, Charless C, Gradinaru, Viviana

“…This protocol describes how to fix, embed, clear and stain excised organs or whole organisms to create optically transparent samples. This versatile protocol…”
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Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop by Wang, Haoqing, Cohen, Alexander A., Galimidi, Rachel P., Gristick, Harry B., Jensen, Grant J., Bjorkman, Pamela J.

“…The HIV-1 envelope (Env) glycoprotein, a trimer of gp120–gp41 heterodimers, relies on conformational flexibility to function in fusing the viral and host…”
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Few and far between: how HIV may be evading antibody avidity by Klein, Joshua S, Bjorkman, Pamela J

“…  [...]the extent and mode of protection are still under debate [2]. [...]a vaccine that effectively stimulates complete protective immunity by the cellular…”
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Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies by Mouquet, Hugo, Scharf, Louise, Euler, Zelda, Liu, Yan, Eden, Caroline, Scheid, Johannes F., Halper-Stromberg, Ariel, Gnanapragasam, Priyanthi N. P., Spencer, Daniel I. R., Seaman, Michael S., Schuitemaker, Hanneke, Feizi, Ten, Nussenzweig, Michel C., Bjorkman, Pamela J.

“…Broadly neutralizing HIV antibodies (bNAbs) can recognize carbohydrate-dependent epitopes on gp120. In contrast to previously characterized glycan-dependent…”
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Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody by Schommers, Philipp, Gruell, Henning, Abernathy, Morgan E., Tran, My-Kim, Dingens, Adam S., Gristick, Harry B., Barnes, Christopher O., Schoofs, Till, Schlotz, Maike, Vanshylla, Kanika, Kreer, Christoph, Weiland, Daniela, Holtick, Udo, Scheid, Christof, Valter, Markus M., van Gils, Marit J., Sanders, Rogier W., Vehreschild, Jörg J., Cornely, Oliver A., Lehmann, Clara, Fätkenheuer, Gerd, Seaman, Michael S., Bloom, Jesse D., Bjorkman, Pamela J., Klein, Florian

“…Broadly neutralizing antibodies (bNAbs) represent a promising approach to prevent and treat HIV-1 infection. However, viral escape through mutation of the…”
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Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques by Shingai, Masashi, Donau, Olivia K, Plishka, Ronald J, Buckler-White, Alicia, Mascola, John R, Nabel, Gary J, Nason, Martha C, Montefiori, David, Moldt, Brian, Poignard, Pascal, Diskin, Ron, Bjorkman, Pamela J, Eckhaus, Michael A, Klein, Florian, Mouquet, Hugo, Cetrulo Lorenzi, Julio Cesar, Gazumyan, Anna, Burton, Dennis R, Nussenzweig, Michel C, Martin, Malcolm A, Nishimura, Yoshiaki

“…It is widely appreciated that effective human vaccines directed against viral pathogens elicit neutralizing antibodies (NAbs). The passive transfer of…”
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HIV therapy by a combination of broadly neutralizing antibodies in humanized mice by Klein, Florian, Halper-Stromberg, Ariel, Horwitz, Joshua A., Gruell, Henning, Scheid, Johannes F., Bournazos, Stylianos, Mouquet, Hugo, Spatz, Linda A., Diskin, Ron, Abadir, Alexander, Zang, Trinity, Dorner, Marcus, Billerbeck, Eva, Labitt, Rachael N., Gaebler, Christian, Marcovecchio, Paola M., Incesu, Reha-Baris, Eisenreich, Thomas R., Bieniasz, Paul D., Seaman, Michael S., Bjorkman, Pamela J., Ravetch, Jeffrey V., Ploss, Alexander, Nussenzweig, Michel C.

“…Passive immunotherapy with a combination of neutralizing monoclonal antibodies is shown to be effective in suppressing HIV replication in a humanized mouse…”
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Structural Characterization of Anti-Inflammatory Immunoglobulin G Fc Proteins by Ahmed, Alysia A., Giddens, John, Pincetic, Andrew, Lomino, Joseph V., Ravetch, Jeffrey V., Wang, Lai-Xi, Bjorkman, Pamela J.

“…Immunoglobulin G (IgG) is a central mediator of host defense due to its ability to recognize and eliminate pathogens. The recognition and effector responses…”
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Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers by Cohen, Alexander A, Yang, Zhi, Gnanapragasam, Priyanthi N P, Ou, Susan, Dam, Kim-Marie A, Wang, Haoqing, Bjorkman, Pamela J

“…Current influenza vaccines do not elicit broadly protective immune responses against multiple strains. New strategies to focus the humoral immune response to…”
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CATNAP: a tool to compile, analyze and tally neutralizing antibody panels by Yoon, Hyejin, Macke, Jennifer, West, Jr, Anthony P, Foley, Brian, Bjorkman, Pamela J, Korber, Bette, Yusim, Karina

“…CATNAP (Compile, Analyze and Tally NAb Panels) is a new web server at Los Alamos HIV Database, created to respond to the newest advances in HIV neutralizing…”
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Peptidoglycan Production by an Insect-Bacterial Mosaic by Bublitz, DeAnna C., Chadwick, Grayson L., Magyar, John S., Sandoz, Kelsi M., Brooks, Diane M., Mesnage, Stéphane, Ladinsky, Mark S., Garber, Arkadiy I., Bjorkman, Pamela J., Orphan, Victoria J., McCutcheon, John P.

“…Peptidoglycan (PG) is a defining feature of bacteria, involved in cell division, shape, and integrity. We previously reported that several genes related to PG…”
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