Search Results - "Bjorkman, Lena I"

Lubricin binds cartilage proteins, cartilage oligomeric matrix protein, fibronectin and collagen II at the cartilage surface by Flowers, Sarah A., Zieba, Agata, Örnros, Jessica, Jin, Chunsheng, Rolfson, Ola, Björkman, Lena I., Eisler, Thomas, Kalamajski, Sebastian, Kamali-Moghaddam, Masood, Karlsson, Niclas G.

“…Lubricin, a heavily O -glycosylated protein, is essential for boundary lubrication of articular cartilage. Strong surface adherence of lubricin is required…”
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Decrease of core 2 O-glycans on synovial lubricin in osteoarthritis reduces galectin-3 mediated crosslinking by Flowers, Sarah A., Thomsson, Kristina A., Ali, Liaqat, Huang, Shan, Mthembu, Yolanda, Regmi, Suresh C., Holgersson, Jan, Schmidt, Tannin A., Rolfson, Ola, Björkman, Lena I., Sundqvist, Martina, Karlsson-Bengtsson, Anna, Jay, Gregory D., Eisler, Thomas, Krawetz, Roman, Karlsson, Niclas G.

“…The synovial fluid glycoprotein lubricin (also known as proteoglycan 4) is a mucin-type O-linked glycosylated biological lubricant implicated to be involved in…”
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Truncated lubricin glycans in osteoarthritis stimulate the synoviocyte secretion of VEGFA, IL-8, and MIP-1 α : Interplay between O -linked glycosylation and inflammatory cytokines by Huang, Shan, Thomsson, Kristina A, Jin, Chunsheng, Ryberg, Henrik, Das, Nabangshu, Struglics, André, Rolfson, Ola, Björkman, Lena I, Eisler, Thomas, Schmidt, Tannin A, Jay, Gregory D, Krawetz, Roman, Karlsson, Niclas G

“…The primary aim of the study was to identify inflammatory markers relevant for osteoarthritis (OA)-related systemic (plasma) and local (synovial fluid, SF)…”
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Author Correction: Cathepsin g Degrades Both Glycosylated and Unglycosylated Regions of Lubricin, a Synovial Mucin by Huang, Shan, Thomsson, Kristina A., Jin, Chunsheng, Alweddi, Sally, Struglics, André, Rolfson, Ola, Björkman, Lena I., Kalamajski, Sebastian, Schmidt, Tannin A., Jay, Gregory D., Krawetz, Roman, Karlsson, Niclas G., Eisler, Thomas

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Cathepsin g Degrades Both Glycosylated and Unglycosylated Regions of Lubricin, a Synovial Mucin by Huang, Shan, Thomsson, Kristina A., Jin, Chunsheng, Alweddi, Sally, Struglics, André, Rolfson, Ola, Björkman, Lena I., Kalamajski, Sebastian, Schmidt, Tannin A., Jay, Gregory D., Krawetz, Roman, Karlsson, Niclas G., Eisler, Thomas

“…Lubricin (PRG4) is a mucin type protein that plays an important role in maintaining normal joint function by providing lubrication and chondroprotection…”
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Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset by Saevarsdottir, Saedis, Stefansdottir, Lilja, Sulem, Patrick, Thorleifsson, Gudmar, Ferkingstad, Egil, Rutsdottir, Gudrun, Glintborg, Bente, Westerlind, Helga, Grondal, Gerdur, Loft, Isabella C, Sorensen, Signe Bek, Lie, Benedicte A, Brink, Mikael, Ärlestig, Lisbeth, Arnthorsson, Asgeir Orn, Baecklund, Eva, Banasik, Karina, Bank, Steffen, Bjorkman, Lena I, Ellingsen, Torkell, Erikstrup, Christian, Frei, Oleksandr, Gjertsson, Inger, Gudbjartsson, Daniel F, Gudjonsson, Sigurjon A, Halldorsson, Gisli H, Hendricks, Oliver, Hillert, Jan, Hogdall, Estrid, Jacobsen, Søren, Jensen, Dorte Vendelbo, Jonsson, Helgi, Kastbom, Alf, Kockum, Ingrid, Kristensen, Salome, Kristjansdottir, Helga, Larsen, Margit H, Linauskas, Asta, Hauge, Ellen-Margrethe, Loft, Anne G, Ludviksson, Bjorn R, Lund, Sigrun H, Markusson, Thorsteinn, Masson, Gisli, Melsted, Pall, Moore, Kristjan H S, Munk, Heidi, Nielsen, Kaspar R, Norddahl, Gudmundur L, Oddsson, Asmundur, Olafsdottir, Thorunn A, Olason, Pall I, Olsson, Tomas, Ostrowski, Sisse Rye, Hørslev-Petersen, Kim, Rognvaldsson, Solvi, Sanner, Helga, Silberberg, Gilad N, Stefansson, Hreinn, Sørensen, Erik, Sørensen, Inge J, Turesson, Carl, Bergman, Thomas, Alfredsson, Lars, Kvien, Tore K, Brunak, Søren, Steinsson, Kristján, Andersen, Vibeke, Andreassen, Ole A, Rantapää-Dahlqvist, Solbritt, Hetland, Merete Lund, Klareskog, Lars, Askling, Johan, Padyukov, Leonid, Pedersen, Ole Bv, Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, Stefansson, Kari

“…To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets. We performed a genome-wide…”
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Severe chronic non-bacterial osteomyelitis in combination with total MPO deficiency and responsiveness to TNFα inhibition by Sundqvist, Martina, Christenson, Karin, Wekell, Per, Björnsdottir, Halla, Dahlstrand Rudin, Agnes, Sanchez Klose, Felix P., Kallinich, Tilmann, Welin, Amanda, Björkman, Lena, Bylund, Johan, Karlsson-Bengtsson, Anna, Berg, Stefan

“…We describe a female patient suffering from severe chronic non-bacterial osteomyelitis (CNO) with systemic inflammation and advanced malnutrition and complete…”
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Cartilage oligomeric matrix protein forms protein complexes with synovial lubricin via non-covalent and covalent interactions by Flowers, Sarah A., PhD, Kalamajski, Sebastian, PhD, Ali, Liaqat, PhD, Björkman, Lena I., MD PhD, Raj, Jaison Rathina, MSc, Aspberg, Anders, PhD, Karlsson, Niclas G., PhD, Jin, Chunsheng, PhD

“…Summary Objective Understanding the cartilage surface structure, lost in arthritic disease, is essential for developing strategies to effectively restore it…”
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