Search Results - "Bjorklund, Mikael"

Cell size homeostasis: Metabolic control of growth and cell division by Björklund, Mikael

“…Joint regulation of growth rate and cell division rate determines cell size. Here we discuss how animal cells achieve cell size homeostasis potentially…”
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Stem cell derived exosomes: microRNA therapy for age-related musculoskeletal disorders by Yao, Xudong, Wei, Wei, Wang, Xiaozhao, Chenglin, Li, Björklund, Mikael, Ouyang, Hongwei

“…Age-associated musculoskeletal disorders (MSDs) have been historically overlooked by mainstream biopharmaceutical researchers. However, it has now been…”
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Modeling homeostasis mechanisms that set the target cell size by Vargas-Garcia, Cesar A., Björklund, Mikael, Singh, Abhyudai

“…How organisms maintain cell size homeostasis is a long-standing problem that remains unresolved, especially in multicellular organisms. Recent experiments in…”
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Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib by Miettinen, Teemu P, Peltier, Julien, Härtlova, Anetta, Gierliński, Marek, Jansen, Valerie M, Trost, Matthias, Björklund, Mikael

“…Palbociclib is a CDK4/6 inhibitor approved for metastatic estrogen receptor‐positive breast cancer. In addition to G1 cell cycle arrest, palbociclib treatment…”
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Modified ribosome profiling reveals high abundance of ribosome protected mRNA fragments derived from 3' untranslated regions by Miettinen, Teemu P, Björklund, Mikael

“…Ribosome profiling identifies ribosome positions on translated mRNAs. A prominent feature of published datasets is the near complete absence of ribosomes in 3'…”
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Cell cycle regulation in NAFLD: when imbalanced metabolism limits cell division by Caldez, Matias J., Bjorklund, Mikael, Kaldis, Philipp

“…Cell division is essential for organismal growth and tissue homeostasis. It is exceptionally significant in tissues chronically exposed to intrinsic and…”
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Metabolic Remodeling during Liver Regeneration by Caldez, Matias J., Van Hul, Noémi, Koh, Hiromi W.L., Teo, Xing Qi, Fan, Jun Jun, Tan, Peck Yean, Dewhurst, Matthew R., Too, Peh Gek, Talib, S. Zakiah A., Chiang, Beatrice E., Stünkel, Walter, Yu, Hanry, Lee, Philip, Fuhrer, Tobias, Choi, Hyungwon, Björklund, Mikael, Kaldis, Philipp

“…Liver disease is linked to a decreased capacity of hepatocytes to divide. In addition, cellular metabolism is important for tissue homeostasis and…”
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Generation of a versatile BiFC ORFeome library for analyzing protein-protein interactions in live Drosophila by Bischof, Johannes, Duffraisse, Marilyne, Furger, Edy, Ajuria, Leiore, Giraud, Guillaume, Vanderperre, Solene, Paul, Rachel, Björklund, Mikael, Ahr, Damien, Ahmed, Alexis W, Spinelli, Lionel, Brun, Christine, Basler, Konrad, Merabet, Samir

“…Transcription factors achieve specificity by establishing intricate interaction networks that will change depending on the cell context. Capturing these…”
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Mitochondrial fragmentation and ROS signaling in wound response and repair by Xu, Shiqi, Li, Shiyao, Bjorklund, Mikael, Xu, Suhong

“…Mitochondria are organelles that serve numerous critical cellular functions, including energy production, Ca 2+ homeostasis, redox signaling, and metabolism…”
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Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion by Sokolova, Maria, Turunen, Mikko, Mortusewicz, Oliver, Kivioja, Teemu, Herr, Patrick, Vähärautio, Anna, Björklund, Mikael, Taipale, Minna, Helleday, Thomas, Taipale, Jussi

“…To identify cell cycle regulators that enable cancer cells to replicate DNA and divide in an unrestricted manner, we performed a parallel genome-wide RNAi…”
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Editorial: Determinants of Cell Size by Björklund, Mikael, Marguerat, Samuel

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In‐cytoplasm mitochondrial transplantation for mesenchymal stem cells engineering and tissue regeneration by Yao, Xudong, Ma, Yuanzhu, Zhou, Wenyan, Liao, Youguo, Jiang, Zongsheng, Lin, Junxin, He, Qiulin, Wu, Hongwei, Wei, Wei, Wang, Xiaozhao, Björklund, Mikael, Ouyang, Hongwei

“…Stem cell therapies are unsatisfactory due to poor cell survival and engraftment. Stem cell used for therapy must be properly “tuned” for a harsh in vivo…”
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Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling by Varjosalo, Markku, Björklund, Mikael, Cheng, Fang, Syvänen, Heidi, Kivioja, Teemu, Kilpinen, Sami, Sun, Zairen, Kallioniemi, Olli, Stunnenberg, Hendrik G., He, Wei-Wu, Ojala, Päivi, Taipale, Jussi

“…To allow genome-scale identification of genes that regulate cellular signaling, we cloned >90% of all human full-length protein kinase cDNAs and constructed…”
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Hyperthermia Selectively Destabilizes Oncogenic Fusion Proteins by Maimaitiyiming, Yasen, Wang, Qian Qian, Yang, Chang, Ogra, Yasumitsu, Lou, Yinjun, Smith, Clayton A, Hussain, Liaqat, Shao, Yi Ming, Lin, Jiebo, Liu, Jinfeng, Wang, Lingfang, Zhu, Yong, Lou, Haiyan, Huang, Yuan, Li, Xiaoxia, Chang, Kao-Jung, Chen, Hao, Li, Hongyan, Huang, Ying, Tse, Eric, Sun, Jie, Bu, Na, Chiou, Shih-Hwa, Zhang, Yan Fang, Hua, Hao Ying, Ma, Li Ya, Huang, Ping, Ge, Ming Hua, Cao, Feng-Lin, Cheng, Xiaodong, Sun, Hongzhe, Zhou, Jin, Vasliou, Vasilis, Xu, Pengfei, Jin, Jie, Bjorklund, Mikael, Zhu, Hong-Hu, Hsu, Chih-Hung, Naranmandura, Hua

“…The PML/RARα fusion protein is the oncogenic driver in acute promyelocytic leukemia (APL). Although most APL cases are cured by PML/RARα-targeting therapy,…”
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The mevalonate pathway as a metabolic requirement for autophagy-implications for growth control, proteostasis, and disease by Miettinen, Teemu P., Björklund, Mikael

“…Autophagy is responsible for the degradation and recycling of cellular proteins and organelles. Our recent work shows that the mevalonate pathway influences…”
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Mitochondrial Function and Cell Size: An Allometric Relationship by Miettinen, Teemu P, Björklund, Mikael

“…Allometric scaling of metabolic rate results in lower total mitochondrial oxygen consumption with increasing organismal size. This is considered a universal…”
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Systematic Screening of a Drosophila ORF Library In Vivo Uncovers Wnt/Wg Pathway Components by Schertel, Claus, Huang, Dashun, Björklund, Mikael, Bischof, Johannes, Yin, Dingzi, Li, Rongxia, Wu, Yi, Zeng, Rong, Wu, Jiarui, Taipale, Jussi, Song, Haiyun, Basler, Konrad

“…We created a site-directed UAS-ORF library of 655 growth-regulating genes in Drosophila. This library represents a large collection of genes regulating cell…”
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Cellular Allometry of Mitochondrial Functionality Establishes the Optimal Cell Size by Miettinen, Teemu P., Björklund, Mikael

“…Eukaryotic cells attempt to maintain an optimal size, resulting in size homeostasis. While cellular content scales isometrically with cell size, allometric…”
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Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential by Zhao, Li Na, Björklund, Mikael, Caldez, Matias J., Zheng, Jie, Kaldis, Philipp

“…Most of the drugs currently prescribed for cancer treatment are riddled with substantial side effects. In order to develop more effective and specific…”
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Reaction of pyridine N-oxides with Grignard reagents: a stereodefined synthesis of substituted dienal oximes by Andersson, Hans, Wang, Xiaoyang, Björklund, Mikael, Olsson, Roger, Almqvist, Fredrik

“…Rapid addition of Grignard reagents to pyridine N-oxides under mild conditions gave stereodefined dienal oximes in good to excellent yields. This reaction…”
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