Search Results - "Bjorklund, Anders"

TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity by Decressac, Mickael, Mattsson, Bengt, Weikop, Pia, Lundblad, Martin, Jakobsson, Johan, Björklund, Anders

“…The aggregation of α-synuclein plays a major role in Parkinson disease (PD) pathogenesis. Recent evidence suggests that defects in the autophagy-mediated…”
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From Skin to Brain: A Parkinson’s Disease Patient Transplanted with His Own Cells by Parmar, Malin, Björklund, Anders

“…In a pioneering study in New England Journal of Medicine, Schweitzer et al. (2020) report on a patient with Parkinson’s disease who received a graft of…”
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Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons by Lundblad, Martin, Decressac, Mickael, Mattsson, Bengt, Björklund, Anders

“…We used in vivo amperometry to monitor changes in synaptic dopamine (DA) release in the striatum induced by overexpression of human wild-type α-synuclein in…”
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GDNF Therapy: Can We Make It Work? by Björklund, Anders

“…In two recent postmortem studies, Jeffrey Kordower and colleagues report new findings that open up for an interesting discussion on the status of GDNF/NRTN…”
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The basal forebrain cholinergic system as target for cell replacement therapy in Parkinson's disease by Björklund, Anders, Barker, Roger A

“…In recent years there has been a renewed interest in the basal forebrain cholinergic system as a target for the treatment of cognitive impairments in patients…”
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The serotonergic system in L-DOPA-induced dyskinesia: pre-clinical evidence and clinical perspective by Carta, Manolo, Björklund, Anders

“…During the last decade, the serotonergic system has emerged as a key player in the appearance of L-DOPA-induced dyskinesia in animal models of Parkinson’s…”
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Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson's disease by Barker, Roger A, Prof, Barrett, Jessica, PhD, Mason, Sarah L, BSc, Björklund, Anders, PhD

“…Summary Clinical use of allografts of fetal ventral mesencephalic tissue as a treatment to replace dopaminergic neurons in patients with Parkinson's disease…”
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Trophic Factor Gene Therapy for Parkinson's Disease by Kordower, Jeffrey H., Bjorklund, Anders

“…ABSTRACT Parkinson's disease (PD) is a chronic and progressive neurodegenerative movement disorder for which there is presently no cure. Pharmacological…”
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Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson’s Disease by Grealish, Shane, Diguet, Elsa, Kirkeby, Agnete, Mattsson, Bengt, Heuer, Andreas, Bramoulle, Yann, Van Camp, Nadja, Perrier, Anselme L., Hantraye, Philippe, Björklund, Anders, Parmar, Malin

“…Considerable progress has been made in generating fully functional and transplantable dopamine neurons from human embryonic stem cells (hESCs). Before these…”
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Neuronal Replacement as a Tool for Basal Ganglia Circuitry Repair: 40 Years in Perspective by Björklund, Anders, Parmar, Malin

“…The ability of new neurons to promote repair of brain circuitry depends on their capacity to re-establish afferent and efferent connections with the host. In…”
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Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain by Li, Wen, Englund, Elisabet, Widner, Ha°kan, Mattsson, Bengt, van Westen, Danielle, Lätt, Jimmy, Rehncrona, Stig, Brundin, Patrik, Björklund, Anders, Lindvall, Olle, Li, Jia-Yi

“…Clinical trials using cells derived from embryonic ventral mesencephalon have shown that transplanted dopaminergic neurons can survive and function in the long…”
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Dopamine neuron systems in the brain: an update by Björklund, Anders, Dunnett, Stephen B

“…The basic organization of the catecholamine-containing neuronal systems and their axonal projections in the brain was initially worked out using classical…”
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Generation of induced neurons via direct conversion in vivo by Torper, Olof, Pfisterer, Ulrich, Wolf, Daniel A., Pereira, Maria, Lau, Shong, Jakobsson, Johan, Björklund, Anders, Grealish, Shane, Parmar, Malin

“…Cellular reprogramming is a new and rapidly emerging field in which somatic cells can be turned into pluripotent stem cells or other somatic cell types simply…”
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In vivo conversion of dopamine neurons in mouse models of Parkinson’s disease — a future approach for regenerative therapy? by Parmar, Malin, Björklund, Anders, Björklund, Tomas

“…Recent advances in cell reprogramming have made it possible to form new therapeutic cells within the body itself via a process called direct conversion or…”
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Direct conversion of human fibroblasts to dopaminergic neurons by Pfisterer, Ulrich, Kirkeby, Agnete, Torper, Olof, Wood, James, Nelander, Jenny, Dufour, Audrey, Björklund, Anders, Lindvall, Olle, Jakobsson, Johan, Parmar, Malin

“…Recent reports demonstrate that somatic mouse cells can be directly converted to other mature cell types by using combined expression of defined factors. Here…”
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The Amphetamine Induced Rotation Test: A Re-Assessment of Its Use as a Tool to Monitor Motor Impairment and Functional Recovery in Rodent Models of Parkinson's Disease by Björklund, Anders, Dunnett, Stephen B

“…Rats and mice with unilateral damage to the nigrostriatal dopamine system-induced by neurotoxins, such as 6-hydroxydopamine, overexpression of α-synuclein, or…”
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Cell Therapeutics in Parkinson’s Disease by Lindvall, Olle, Björklund, Anders

“…The main pathology underlying motor symptoms in Parkinson’s disease (PD) is a rather selective degeneration of nigrostriatal dopamine (DA) neurons…”
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The history and status of dopamine cell therapies for Parkinson's disease by Barker, Roger A, Björklund, Anders, Parmar, Malin

“…Parkinson's disease (PD) is characterized by the loss of the dopaminergic nigrostriatal pathway which has led to the successful development of drug therapies…”
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TFEB: Pathogenic role and therapeutic target in Parkinson disease by Decressac, Mickael, Björklund, Anders

“…Parkinson disease (PD) is characterized by the progressive loss of nigral dopamine neurons and the presence of accumulations containing the disease-causing…”
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NURR1 in Parkinson disease—from pathogenesis to therapeutic potential by Decressac, Mickael, Volakakis, Nikolaos, Björklund, Anders, Perlmann, Thomas

“…Parkinson disease (PD) pathogenesis involves dysfunction and eventual death of midbrain dopaminergic neurons. Emerging evidence points to a role for the…”
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