Search Results - "Bjelic, M. M."

Circadian rhythm of the Leydig cells endocrine function is attenuated during aging by Baburski, Aleksandar Z., Sokanovic, Srdjan J., Bjelic, Maja M., Radovic, Sava M., Andric, Silvana A., Kostic, Tatjana S.

“…Although age-related hypofunction of Leydig cells is well illustrated across species, its circadian nature has not been analyzed. Here we describe changes in…”
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Age related changes of cAMP and MAPK signaling in Leydig cells of Wistar rats by Sokanovic, S.J., Janjic, M.M., Stojkov, N.J., Baburski, A.Z., Bjelic, M.M., Andric, S.A., Kostic, T.S.

“…Here, we chronologically analyzed age-associated changes of cAMP- and MAPK-signaling in Leydig cells (LCs) in relation with decreased testosterone (T)…”
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Repeated immobilization stress disturbed steroidogenic machinery and stimulated the expression of cAMP signaling elements and adrenergic receptors in Leydig cells by Stojkov, Natasa J, Janjic, Marija M, Bjelic, Maja M, Mihajlovic, Aleksandar I, Kostic, Tatjana S, Andric, Silvana A

“…This study was designed to evaluate the effect of acute (2 h daily) and repeated (2 h daily for 2 or 10 consecutive days) immobilization stress (IMO) on: 1)…”
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The opposite roles of glucocorticoid and α1-adrenergic receptors in stress triggered apoptosis of rat Leydig cells by Andric, Silvana A, Kojic, Zvezdana, Bjelic, Maja M, Mihajlovic, Aleksandar I, Baburski, Aleksandar Z, Sokanovic, Srdjan J, Janjic, Marija M, Stojkov, Natasa J, Stojilkovic, Stanko S, Kostic, Tatjana S

“…The stress-induced initiation of proapoptotic signaling in Leydig cells is relatively well defined, but the duration of this signaling and the mechanism(s)…”
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In vivo blockade of  1-adrenergic receptors mitigates stress-disturbed cAMP and cGMP signaling in Leydig cells by Stojkov, N. J., Baburski, A. Z., Bjelic, M. M., Sokanovic, S. J., Mihajlovic, A. I., Drljaca, D. M., Janjic, M. M., Kostic, T. S., Andric, S. A.

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Melatonin replacement restores the circadian behavior in adult rat Leydig cells after pinealectomy by Baburski, Aleksandar Z., Sokanovic, Srdjan J., Janjic, Marija M., Stojkov-Mimic, Natasa J., Bjelic, Maja M., Andric, Silvana A., Kostic, Tatjana S.

“…Melatonin actions on oscillators in reproductive organs are poorly understood. Here we analyzed melatonin effects on rhythmic expression of clock and…”
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Enhanced Recovery after Surgery in Patients Implanted with Left Ventricular Assist Device by Lindenmuth, D., Chase, K., Cheyne, C., Bjelic, M., Gosev, I.

“…We sought to develop and implement a comprehensive enhanced recovery after surgery protocol for patients implanted with left ventricular assist device. Our…”
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The Opposing Roles of Nitric Oxide and cGMP in the Age-Associated Decline in Rat Testicular Steroidogenesis by Sokanovic, Srdjan J, Baburski, Aleksandar Z, Janjic, Marija M, Stojkov, Natasa J, Bjelic, Maja M, Lalosevic, Dusan, Andric, Silvana A, Stojilkovic, Stanko S, Kostic, Tatjana S

“…The molecular mechanism of the aging-associated dysfunction of Leydig cells (LCs) is complex and poorly understood. In this study, we analyzed the contribution…”
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Pharmacological doses of testosterone upregulated androgen receptor and 3-Beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase and impaired leydig cells steroidogenesis in adult rats by Kostic, Tatjana S, Stojkov, Natasa J, Bjelic, Maja M, Mihajlovic, Aleksandar I, Janjic, Marija M, Andric, Silvana A

“…Anabolic androgenic steroids (AAS) are testosterone derivatives originally designed to enhance muscular mass and used for the treatment of many clinical…”
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Prolonged in vivo administration of testosterone-enanthate, the widely used and abused anabolic androgenic steroid, disturbs prolactin and cAMP signaling in Leydig cells of adult rats by Bjelic, Maja M., Stojkov, Natasa J., Radovic, Sava M., Baburski, Aleksandar Z., Janjic, Marija M., Kostic, Tatjana S., Andric, Silvana A.

“…[Display omitted] •Administration of testosterone-enanthate for 10-weeks increased prolactin in pituitary.•Prolactin and increased Jak2/Jak3 could account for…”
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Molecular adaptations of testosterone-producing Leydig cells during systemic in vivo blockade of the androgen receptor by Bjelic, Maja M., Stojkov, Natasa J., Baburski, Aleksandar Z., Sokanovic, Srdjan J., Mihajlovic, Aleksandar I., Janjic, Marija M., Kostic, Tatjana S., Andric, Silvana A.

“…•Androcur prevented testosterone-reduced Leydig cells steroidogenic capacity/activity.•Androcur completely abolished testosterone-reduced expression of…”
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Coronary artery disease and the risk of life-threatening cardiac events after age 40 in long QT syndrome by Barsheshet, A, Goldenberg, I, Bjelic, M, Buturlin, K, Erez, A, Goldenberg, G, Chen, A Y, Polonsky, B, Mcnitt, S, Aktas, M, Zareba, W, Golovchiner, G

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Transient Rise of Serum Testosterone Level after Single Sildenafil Treatment of Adult Male Rats by Janjic, Marija M., Stojkov, Natasa J., Bjelic, Maja M., Mihajlovic, Aleksandar I., Andric, Silvana A., Kostic, Tatjana S.

“…Phosphodiesterase type 5 (PDE5) inhibitors have been established in therapy for a variety of physiological disorders including erectile dysfunction. Despite…”
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Sustained in vivo blockade of α₁-adrenergic receptors prevented some of stress-triggered effects on steroidogenic machinery in Leydig cells by Stojkov, Natasa J, Janjic, Marija M, Baburski, Aleksandar Z, Mihajlovic, Aleksandar I, Drljaca, Dragana M, Sokanovic, Srdjan J, Bjelic, Maja M, Kostic, Tatjana S, Andric, Silvana A

“…This study was designed to systematically analyze and evaluate the effects of in vivo blockade of α₁-adrenergic receptors (α₁-ADRs) on the stress-induced…”
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Intratesticular alpha1-adrenergic receptors mediate stress-disturbed transcription of steroidogenic stimulator NUR77 as well as steroidogenic repressors DAX1 and ARR19 in Leydig cells of adult rats by Stojkov-Mimic, Natasa J., Bjelic, Maja M., Radovic, Sava M., Mihajlovic, Aleksandar I., Sokanovic, Srdjan J., Baburski, Aleksandar Z., Janjic, Marija M., Kostic, Tatjana S., Andric, Silvana A.

“…•In vivo blockade of testicular α1-ADRs reduces circulating androgen level.•α1-ADR blockade abolished stress-induced partial recovery of androgen…”
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Less Invasive HeartMate 3 Implantation is a Safe and Effective Approach for Obese Patients by Bjelic, M., Ayers, B., Barrus, B., Vidula, H., Alexis, J., Paic, F., Prasad, S., Gosev, I.

“…The present study aimed to compare the outcomes of obese patients who underwent HeartMate 3 implantation through less invasive surgery (LIS) with those who…”
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Time out of Therapeutic Range and Relationship with Thrombotic and Bleeding Outcomes amongst Patients with HeartMate 3 Continuous Flow Left Ventricular Assist Device by Louis, C., McGann, K.C., Bjelic, M., Bhagat, R., Cheyne, C., Barrus, B., Prasad, S., Gosev, I.

“…We evaluated outcomes in patients with third-generation Heartmate (HM3) left ventricular assist devices (LVAD), stratified by international normalized ratio…”
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The Effects of Nighttime Surgery on Outcomes Following Orthotopic Heart Transplantation: An Analysis of the UNOS Database by Bjelic, M., Martens, J., Louis, C., Chen, L., Barrus, B., Gosev, I.

“…The purpose of the present study is to examine the effect of operative time of day on outcomes in orthotopic heart transplant (OHT) recipients. We hypothesized…”
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Less Invasive Left Ventricular Assist Device Implantation is Safe and Feasible in Patients with Smaller Body Surface Area by Wood, K.L., Bjelic, M., Paic, F., Vidula, H., Cheyne, C., Chase, K., Bernstein, W., Wyrobek, J.A., Alexis, J.D., Gosev, I.

“…Smaller body surface area (BSA) frequently precludes patients for Left Ventricular Assist Device (LVAD) therapy. We sought to investigate the clinical outcomes…”
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Safety and Efficacy of Home-Based Exercise Rehabilitation Using Remote Monitoring in New Left Ventricular Assist Device Recipients by Vidula, H., McNitt, S., Dennison, C., Sampath, R., Bjelic, M., Sziveri, Z., Alexis, J., Gosev, I., Caufield, L., Goldenberg, I.

“…Data on home-based exercise rehabilitation (HER), using a wearable activity monitor and smartphone app, are limited in LVAD recipients. The purpose of the…”
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