Search Results - "Bjørbæk, Christian"

Leptin revisited: its mechanism of action and potential for treating diabetes by Coppari, Roberto, Bjørbæk, Christian

“…Key Points Leptin is a hormone that is produced by adipose tissue and regulates appetite, body weight, neuroendocrine functions and glycaemia. In this Review,…”
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Central Leptin Receptor Action and Resistance in Obesity by Bjørbæk, Christian

“…The discovery of leptin in 1994 has led to remarkable advances in obesity research. We now know that leptin is a cytokinelike hormone that is produced in…”
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Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice by Münzberg, Heike, Flier, Jeffrey S, Bjørbæk, Christian

“…Leptin resistance in diet-induced obese (DIO) mice is characterized by elevated serum leptin and a decreased response to exogenous leptin and is caused by…”
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Leptin and the Control of Food Intake: Neurons in the Nucleus of the Solitary Tract Are Activated by Both Gastric Distension and Leptin by Huo, Lihong, Maeng, Lisa, Bjørbæk, Christian, Grill, Harvey J

“…Leptin reduces food intake by an unspecified mechanism. Studies show that forebrain ventricular leptin delivery increases the inhibitory effects of…”
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Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling by Huang, Hu, Kong, Dong, Byun, Kyung Hee, Ye, Chianping, Koda, Shuichi, Lee, Dae Ho, Oh, Byung-Chul, Lee, Sam W, Lee, Bonghee, Zabolotny, Janice M, Kim, Min Seon, Bjørbæk, Christian, Lowell, Bradford B, Kim, Young-Bum

“…Leptin regulates energy balance. The authors show that Rho-kinase 1 (ROCK1) regulates leptin signaling by increasing activation of signaling molecules…”
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Over-expression of leptin receptors in hypothalamic POMC neurons increases susceptibility to diet-induced obesity by Gamber, Kevin M, Huo, Lihong, Ha, Sangdeuk, Hairston, Joyce E, Greeley, Sarah, Bjørbæk, Christian

“…Diet-induced obesity (DIO) in rodents is characterized by impaired activation of signal-transducer and activator of transcription 3 (STAT3) by leptin receptors…”
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Divergent Leptin Signaling in Proglucagon Neurons of the Nucleus of the Solitary Tract in Mice and Rats by Huo, Lihong, Gamber, Kevin M, Grill, Harvey J, Bjørbæk, Christian

“…The central targets mediating the anorectic and other actions of leptin have yet to be fully identified. Although previous studies focused on the hypothalamus,…”
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Overexpression of Suppressor of Cytokine Signaling 3 in Adipose Tissue Causes Local but Not Systemic Insulin Resistance by HANG SHI, CAVE, Belinda, INOUYE, Karen, BJØRBAEK, Christian, FLIER, Jeffrey S

“…Overexpression of Suppressor of Cytokine Signaling 3 in Adipose Tissue Causes Local but Not Systemic Insulin Resistance Hang Shi , Belinda Cave , Karen Inouye…”
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Hypothalamic Agouti-Related Peptide Neurons and the Central Melanocortin System Are Crucial Mediators of Leptin’s Antidiabetic Actions by Gonçalves, Gabriel H.M., Li, Wenjing, Garcia, Adriana V.C.-G., Figueiredo, Mariana S., Bjørbæk, Christian

“…Leptin has beneficial effects on glucose metabolism via actions in the hypothalamus, but the roles of specific subgroups of neurons responsible for these…”
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Somato-dendritic localization and signaling by leptin receptors in hypothalamic POMC and AgRP neurons by Ha, Sangdeuk, Baver, Scott, Huo, Lihong, Gata, Adriana, Hairston, Joyce, Huntoon, Nicholas, Li, Wenjing, Zhang, Thompson, Benecchi, Elizabeth J, Ericsson, Maria, Hentges, Shane T, Bjørbæk, Christian

“…Leptin acts via neuronal leptin receptors to control energy balance. Hypothalamic pro-opiomelanocortin (POMC) and agouti-related peptide (AgRP)/Neuropeptide Y…”
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The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis by Üner, Aykut, Gonçalves, Gabriel H.M, Li, Wenjing, Porceban, Matheus, Caron, Nicole, Schönke, Milena, Delpire, Eric, Sakimura, Kenji, Bjørbæk, Christian

“…Abstract Objective Hypothalamic agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) expressing neurons play critical roles in control of energy…”
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The Role of SOCS-3 in Leptin Signaling and Leptin Resistance by Bjørbæk, Christian, El-Haschimi, Karim, Frantz, J. Daniel, Flier, Jeffrey S.

“…We earlier demonstrated that leptin induces expression of SOCS-3 mRNA in the hypothalamus. Furthermore, transfection data suggest that SOCS-3 is an inhibitor…”
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Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor by Bjørbæk, Christian, Uotani, Shigeo, da Silva, Barbara, Flier, Jeffrey S.

“…Leptin receptors include a long form (OBRl) with 302 cytoplasmic residues that is presumed to mediate most or all of leptins signaling, and several short…”
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Characterizaton of Short Isoforms of the Leptin Receptor in Rat Cerebral Microvessels and of Brain Uptake of Leptin in Mouse Models of Obesity by Hileman, Stanley M, Pierroz, Dominique D, Masuzaki, Hiroaki, Bjørbæk, Christian, El-Haschimi, Karim, Banks, William A, Flier, Jeffrey S

“…Leptin deficiency causes obesity in rodents and humans, but circulating levels of leptin are paradoxically elevated in obesity. The mechanisms underlying this…”
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Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance by Bjørbæk, Christian, Elmquist, Joel K, Frantz, J.Daniel, Shoelson, Steven E, Flier, Jeffrey S

“…Leptin affects food intake and body weight by actions on the hypothalamus. Although leptin resistance is common in obesity, mechanisms have not been…”
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Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling by Harris, M, Aschkenasi, C, Elias, C F, Chandrankunnel, A, Nillni, E A, Bjøorbaek, C, Elmquist, J K, Flier, J S, Hollenberg, A N

“…Starvation causes a rapid reduction in thyroid hormone levels in rodents. This adaptive response is caused by a reduction in thyrotropin-releasing hormone…”
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Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons by Huo, Lihong, Gamber, Kevin, Greeley, Sarah, Silva, Jose, Huntoon, Nicholas, Leng, Xing-Hong, Bjørbæk, Christian

“…Leptin plays a pivotal role in regulation of energy balance. Via unknown central pathways, leptin also affects peripheral glucose homeostasis and locomotor…”
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Leptin modulates the intrinsic excitability of AgRP/NPY neurons in the arcuate nucleus of the hypothalamus by Baver, Scott B, Hope, Kevin, Guyot, Shannon, Bjørbaek, Christian, Kaczorowski, Catherine, O'Connell, Kristen M S

“…The hypothalamic arcuate nucleus (ARH) is a brain region critical for regulation of food intake and a primary area for the action of leptin in the CNS. In lean…”
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Transcellular Transport of Leptin by the Short Leptin Receptor Isoform ObRa in Madin-Darby Canine Kidney Cells by Hileman, Stanley M., Tornøe, Jens, Flier, Jeffrey S., Bjørbæk, Christian

“…Abstract Leptin is an adipocyte-derived hormone that acts in specific regions of the brain to regulate body weight and neuroendocrine function. The mechanism…”
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Role of POMC and AgRP neuronal activities on glycaemia in mice by Üner, Aykut Göktürk, Keçik, Onur, Quaresma, Paula G. F., De Araujo, Thiago M., Lee, Hyon, Li, Wenjing, Kim, Hyun Jeong, Chung, Michelle, Bjørbæk, Christian, Kim, Young-Bum

“…Leptin regulates both feeding and glycaemia primarily through its receptors expressed on agouti-related peptide (AgRP) and pro-opiomelanocortin-expressing…”
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