Search Results - "Björkman, J A"

Local proCPU (TAFI) activation during thrombolytic treatment in a dog model of coronary artery thrombosis can be inhibited with a direct, small molecule thrombin inhibitor (melagatran) by Mattsson, C, Björkman, J A, Abrahamsson, T, Nerme, V, Schatteman, K, Leurs, J, Scharpé, S, Hendriks, D

“…To test the hypothesis that the direct thrombin inhibitor, melagatran is able to inhibit local pro-carboxypeptidase U (proCPU) activation that occurs during…”
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Human target validation of phosphoinositide 3‐kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor by NYLANDER, S., KULL, B., BJÖRKMAN, J. A., ULVINGE, J. C., OAKES, N., EMANUELSSON, B. M., ANDERSSON, M., SKÄRBY, T., INGHARDT, T., FJELLSTRÖM, O., GUSTAFSSON, D.

“…Nylander S, Kull B, Björkman JA, Ulvinge JC, Oakes N, Emanuelsson BM, Andersson M, Skärby T, Inghardt T, Fjellström O, Gustafsson D. Human target validation of…”
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Pharmacokinetics of New Calcium Channel Antagonist Clevidipine in the Rat, Rabbit, and Dog and Pharmacokinetic/Pharmacodynamic Relationship in Anesthetized Dogs by ERICSSON, H, THOLANDER, B, BJÖRKMAN, J. A, NORDLANDER, M, REGARDH, C. G

“…Clevidipine is a new vascular selective calcium channel antagonist of the dihydropyridine type, structurally related to felodipine. Clinical trials have shown…”
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Probing protein-protein interactions. The ribose-binding protein in bacterial transport and chemotaxis by Björkman, A J, Binnie, R A, Zhang, H, Cole, L B, Hermodson, M A, Mowbray, S L

“…A number of mutations at Gly134 of the periplasmic ribose-binding protein of Escherichia coli were examined by a combined biochemical and structural approach…”
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Multiple open forms of ribose-binding protein trace the path of its conformational change by Björkman, A.Joakim, Mowbray, Sherry L

“…Conformational changes are necessary for the function of bacterial periplasmic receptors in chemotaxis and transport. Such changes allow entry and exit of…”
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Characterization and molecular cloning of vascular neuropeptide Y receptor subtypes in pig and dog by Malmström, Rickard E., Hökfelt, Tomas, Björkman, Jan-Arne, Nihlén, Carina, Byström, Mona, Ekstrand, A.Jonas, Lundberg, Jan M.

“…Cloning with subsequent in vitro and in vivo characterization of vascular neuropeptide Y (NPY) receptor subtypes in porcine and canine peripheral tissues was…”
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Melagatran, hirudin and heparin as adjuncts to tissue-type plasminogen activator in a canine model of coronary artery thrombolysis by Mattsson, C., Björkman, J.-A., Ulvinge, J.-C.

“…The objective of this study was to characterize the modulation of recombinant tissue-type plasminogen activator (rt-PA)-induced thrombolysis by three thrombin…”
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Myocardial uptake and release of lactate after high dose neurolept endotracheal intubation in coronary surgery by THORELIUS, J, WESSLEN, O, BJÖRKMAN, J.-A, EKROTH, R, JOACHIMSSON, P.-O, RONQUIST, G, TYDEN, H

“…To evaluate the relationship between the hemodynamic and ECG variables used in routine surveillance of coronary surgery and myocardial lactate metabolism, 23…”
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Conformational changes of ribose-binding protein and two related repressors are tailored to fit the functional need by Mowbray, Sherry L, Björkman, A.Joakim

“…The structures and conformational changes of the periplasmic ribose-binding protein and two repressors, PurR and LacI, were compared. Although the closed,…”
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Studies on cardiac distribution and function of neuropeptide Y by Allen, J M, Gjörstrup, P, Björkman, J A, Ek, L, Abrahamsson, T, Bloom, S R

“…High concentrations of a novel peptide, neuropeptide Y, have been demonstrated in the guinea-pig and canine heart and in the latter, a particularly high…”
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Ischemic and nonischemic tissue concentrations of felodipine after coronary venous retroinfusion during myocardial ischemia and reperfusion: an experimental study in pigs by Haga, Y, Uriuda, Y, Björkman, J A, Hatori, N, Johansson, L, Nordlander, R, Sjöquist, P O, Rydén, L

“…Tissue and plasma concentrations of felodipine, a dihydropyridine (DHP) calcium antagonist, retroinfused through the coronary venous system were studied in 27…”
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Superoxide dismutase and catalase do not improve recovery of regional myocardial contractile function when given at the time of reperfusion after reversible regional ischemia in anesthetized dogs by BJORKMAN, J.-A, SUTHERLAND, I, GUSTAFSSON, D, SJOQUIST, P.-O, ABRAHAMSSON, T

“…Earlier studies have demonstrated an improvement in the recovery of the regional myocardial function after reversible myocardial ischemia when dogs were…”
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Prostacyclin synthesis in relation to sympathoadrenal activation. Effects of beta-blockade by Pettersson, K, Hansson, G, Björkman, J A, Ablad, B

“…Results from several studies suggest that beta-adrenoceptor blockade causes increased biosynthesis of the vasodilator prostanoid prostacyclin in the arterial…”
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Cardiac Sympathetic Nerve Stimulation Triggers Coronary t-PA Release by Björkman, Jan-Arne, Jern, Sverker, Jern, Christina

“…OBJECTIVE—This study was undertaken to determine whether stimulation of sympathetic cardiac nerves induces release of the thrombolytic enzyme tissue-type…”
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COMPARISON OF THE QT INTERVAL RESPONSE DURING SINUS- AND PACED RHYTHM IN THE CONSCIOUS AND ANAESTHETIZED BEAGLE DOG by Ollerstam, A., Visser, S.A.G., Duker, G., Forsberg, T., Persson, A.H., Nilsson, L.B., Björkman, J.-A., Gabrielsson, J., Al-Saffar, A.

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The positive inotropic effect of felodipine in isovolumically beating dog heart by Pettersson, K, Noble, M I, Björkman, J A, Hynd, J, Drake-Holland, A J

“…Felodipine is a potent arteriolar vasodilator. Its possible myocardial effects were studied by placing dogs anaesthetized with chloralose on cardiopulmonary…”
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Central hemodynamic effects of adrenaline with special reference to beta 2-adrenergic influence on heart rate and cardiac afterload in anesthetized cats by Gustafsson, D, Björkman, J A

“…Central hemodynamic responses evoked by i.v. infusions of adrenaline and noradrenaline were studied in normovolemic anesthetized cats with intact…”
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Usefulness of a nanoparticle formulation to investigate some hemodynamic parameters of a poorly soluble compound by Sigfridsson, Kalle, Björkman, Jan-Arne, Skantze, Pia, Zachrisson, Helen

“…Drug solubility is an important issue when progressing investigational compounds into clinical candidates. The present paper describes the development and…”
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Derivation of haemodynamic information from ultrasonic recordings of aortic diameter changes by Gustafsson, D, Stale, H, Björkman, J A, Gennser, G

“…An ultrasound phase-locked echo-tracking system was used for noninvasive measurements of diameter changes in the upper abdominal aorta of the anaesthetised…”
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The role of sympathetic activity in atherogenesis: effects of beta-blockade by Ablad, B, Björkman, J A, Gustafsson, D, Hansson, G, Ostlund-Lindqvist, A M, Pettersson, K

“…Clinical and experimental evidence points to potential antiatherosclerotic effects of certain beta-adrenoreceptor antagonists. Long-term treatment with…”
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