Search Results - "Björkegren, Johan"

Atherosclerosis: Recent developments by Björkegren, Johan L.M., Lusis, Aldons J.

“…Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the…”
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Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination by Muhl, Lars, Genové, Guillem, Leptidis, Stefanos, Liu, Jianping, He, Liqun, Mocci, Giuseppe, Sun, Ying, Gustafsson, Sonja, Buyandelger, Byambajav, Chivukula, Indira V., Segerstolpe, Åsa, Raschperger, Elisabeth, Hansson, Emil M., Björkegren, Johan L. M., Peng, Xiao-Rong, Vanlandewijck, Michael, Lendahl, Urban, Betsholtz, Christer

“…Many important cell types in adult vertebrates have a mesenchymal origin, including fibroblasts and vascular mural cells. Although their biological importance…”
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PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data by Franzén, Oscar, Gan, Li-Ming, Björkegren, Johan L M

“…Single-cell RNA sequencing is an increasingly used method to measure gene expression at the single cell level and build cell-type atlases of tissues. Hundreds…”
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Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CVD Series (Part 2) by Moore, Kathryn J, Koplev, Simon, Fisher, Edward A, Tabas, Ira, Björkegren, Johan L M, Doran, Amanda C, Kovacic, Jason C

“…Atherosclerosis is characterized by the retention of modified lipoproteins in the arterial wall. These modified lipoproteins activate resident macrophages and…”
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Opportunities and challenges for transcriptome-wide association studies by Wainberg, Michael, Sinnott-Armstrong, Nasa, Mancuso, Nicholas, Barbeira, Alvaro N., Knowles, David A., Golan, David, Ermel, Raili, Ruusalepp, Arno, Quertermous, Thomas, Hao, Ke, Björkegren, Johan L. M., Im, Hae Kyung, Pasaniuc, Bogdan, Rivas, Manuel A., Kundaje, Anshul

“…Transcriptome-wide association studies (TWAS) integrate genome-wide association studies (GWAS) and gene expression datasets to identify gene–trait…”
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Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases by Franzén, Oscar, Ermel, Raili, Cohain, Ariella, Akers, Nicholas K., Di Narzo, Antonio, Talukdar, Husain A., Foroughi-Asl, Hassan, Giambartolomei, Claudia, Fullard, John F., Sukhavasi, Katyayani, Köks, Sulev, Gan, Li-Ming, Giannarelli, Chiara, Kovacic, Jason C., Betsholtz, Christer, Losic, Bojan, Michoel, Tom, Hao, Ke, Roussos, Panos, Skogsberg, Josefin, Ruusalepp, Arno, Schadt, Eric E., Björkegren, Johan L. M.

“…Genome-wide association studies (GWAS) have identified hundreds of cardiometabolic disease (CMD) risk loci. However, they contribute little to genetic…”
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Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits by Zhang, Wen, Voloudakis, Georgios, Rajagopal, Veera M., Readhead, Ben, Dudley, Joel T., Schadt, Eric E., Björkegren, Johan L. M., Kim, Yungil, Fullard, John F., Hoffman, Gabriel E., Roussos, Panos

“…Transcriptome-wide association studies integrate gene expression data with common risk variation to identify gene-trait associations. By incorporating…”
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alona: a web server for single-cell RNA-seq analysis by Franzen, O, Bjorkegren, JLM

“…Abstract Summary Single-cell RNA sequencing (scRNA-seq) is a technology to measure gene expression in single cells. It has enabled discovery of new cell types…”
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JCAD Gene at the 10p11 Coronary Artery Disease Locus Regulates Hippo Signaling in Endothelial Cells by Jones, Peter D, Kaiser, Michael A, Ghaderi Najafabadi, Maryam, Koplev, Simon, Zhao, Yuqi, Douglas, Gillian, Kyriakou, Theodosios, Andrews, Sarah, Rajmohan, Rathinasabapathy, Watkins, Hugh, Channon, Keith M, Ye, Shu, Yang, Xia, Björkegren, Johan L.M, Samani, Nilesh J, Webb, Tom R

“…OBJECTIVE—A large number of genetic loci have been associated with risk of coronary artery disease (CAD) through genome-wide association studies, however, for…”
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HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology by Rosenson, Robert S., Brewer, H. Bryan, Barter, Philip J., Björkegren, Johan L. M., Chapman, M. John, Gaudet, Daniel, Kim, Daniel Seung, Niesor, Eric, Rye, Kerry-Anne, Sacks, Frank M., Tardif, Jean-Claude, Hegele, Robert A.

“…Key Points High HDL-cholesterol (HDL-C) level in plasma is a robust marker of reduced risk of cardiovascular disease; but the cholesterol content of HDL is not…”
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Sex differences in human adipose tissue gene expression and genetic regulation involve adipogenesis by Anderson, Warren D, Soh, Joon Yuhl, Innis, Sarah E, Dimanche, Alexis, Ma, Lijiang, Langefeld, Carl D, Comeau, Mary E, Das, Swapan K, Schadt, Eric E, Björkegren, Johan L M, Civelek, Mete

“…Sex differences in adipose tissue distribution and function are associated with sex differences in cardiometabolic disease. While many studies have revealed…”
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Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis by Björkegren, Johan L M, Hägg, Sara, Talukdar, Husain A, Foroughi Asl, Hassan, Jain, Rajeev K, Cedergren, Cecilia, Shang, Ming-Mei, Rossignoli, Aránzazu, Takolander, Rabbe, Melander, Olle, Hamsten, Anders, Michoel, Tom, Skogsberg, Josefin

“…Plasma cholesterol lowering (PCL) slows and sometimes prevents progression of atherosclerosis and may even lead to regression. Little is known about how…”
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Histone deacetylase 9 promotes endothelial-mesenchymal transition and an unfavorable atherosclerotic plaque phenotype by Lecce, Laura, Xu, Yang, V'Gangula, Bhargavi, Chandel, Nirupama, Pothula, Venu, Caudrillier, Axelle, Santini, Maria Paola, d'Escamard, Valentina, Ceholski, Delaine K, Gorski, Przemek A, Ma, Lijiang, Koplev, Simon, Bjørklund, Martin Mæng, Björkegren, Johan Lm, Boehm, Manfred, Bentzon, Jacob Fog, Fuster, Valentin, Kim, Ha Won, Weintraub, Neal L, Baker, Andrew H, Bernstein, Emily, Kovacic, Jason C

“…Endothelial-mesenchymal transition (EndMT) is associated with various cardiovascular diseases and in particular with atherosclerosis and plaque instability…”
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Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade by Wang, Ying, Nanda, Vivek, Direnzo, Daniel, Ye, Jianqin, Xiao, Sophia, Kojima, Yoko, Howe, Kathryn L., Jarr, Kai-Uwe, Flores, Alyssa M., Tsantilas, Pavlos, Tsao, Noah, Rao, Abhiram, Newmane, Alexandra A. C., Eberhard, Anne V., Priest, James R., Ruusalepp, Arno, Pasterkamp, Gerard, Maegdefessel, Lars, Miller, Clint L., Lind, Lars, Koplev, Simon, Björkegren, Johan L. M., Owense, Gary K., Ingelsson, Erik, Weissmanr, Irving L., Leeper, Nicholas J.

“…Atherosclerosis is the process underlying heart attack and stroke. Despite decades of research, its pathogenesis remains unclear. Dogma suggests that…”
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Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis by Alencar, Gabriel F., Owsiany, Katherine M., Karnewar, Santosh, Sukhavasi, Katyayani, Mocci, Giuseppe, Nguyen, Anh T., Williams, Corey M., Shamsuzzaman, Sohel, Mokry, Michal, Henderson, Christopher A., Haskins, Ryan, Baylis, Richard A., Finn, Aloke V., McNamara, Coleen A., Zunder, Eli R., Venkata, Vamsidhar, Pasterkamp, Gerard, Björkegren, Johan, Bekiranov, Stefan, Owens, Gary K.

“…Rupture and erosion of advanced atherosclerotic lesions with a resultant myocardial infarction or stroke are the leading worldwide cause of death. However, we…”
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NEW: network-enabled wisdom in biology, medicine, and health care by Schadt, Eric E, Björkegren, Johan L M

“…Complete repertoires of molecular activity in and between tissues provided by new high-dimensional "omics" technologies hold great promise for characterizing…”
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Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci by Miller, Clint L., Pjanic, Milos, Wang, Ting, Nguyen, Trieu, Cohain, Ariella, Lee, Jonathan D., Perisic, Ljubica, Hedin, Ulf, Kundu, Ramendra K., Majmudar, Deshna, Kim, Juyong B., Wang, Oliver, Betsholtz, Christer, Ruusalepp, Arno, Franzén, Oscar, Assimes, Themistocles L., Montgomery, Stephen B., Schadt, Eric E., Björkegren, Johan L.M., Quertermous, Thomas

“…Coronary artery disease (CAD) is the leading cause of mortality and morbidity, driven by both genetic and environmental risk factors. Meta-analyses of…”
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Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease by Zeng, Lingyao, Talukdar, Husain A., Koplev, Simon, Giannarelli, Chiara, Ivert, Torbjörn, Gan, Li-Ming, Ruusalepp, Arno, Schadt, Eric E., Kovacic, Jason C., Lusis, Aldons J., Michoel, Tom, Schunkert, Heribert, Björkegren, Johan L.M.

“…Genetic variants currently known to affect coronary artery disease (CAD) risk explain less than one-quarter of disease heritability. The heritability…”
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Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus by Nanda, Vivek, Wang, Ting, Pjanic, Milos, Liu, Boxiang, Nguyen, Trieu, Matic, Ljubica Perisic, Hedin, Ulf, Koplev, Simon, Ma, Lijiang, Franzén, Oscar, Ruusalepp, Arno, Schadt, Eric E, Björkegren, Johan L M, Montgomery, Stephen B, Snyder, Michael P, Quertermous, Thomas, Leeper, Nicholas J, Miller, Clint L

“…Recent genome-wide association studies (GWAS) have identified multiple new loci which appear to alter coronary artery disease (CAD) risk via arterial…”
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Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells by Aherrahrou, Redouane, Guo, Liang, Nagraj, V. Peter, Aguhob, Aaron, Hinkle, Jameson, Chen, Lisa, Yuhl Soh, Joon, Lue, Dillon, Alencar, Gabriel F., Boltjes, Arjan, van der Laan, Sander W., Farber, Emily, Fuller, Daniela, Anane-Wae, Rita, Akingbesote, Ngozi, Manichaikul, Ani W., Ma, Lijiang, Kaikkonen, Minna U., Björkegren, Johan L.M., Önengüt-Gümüşcü, Suna, Pasterkamp, Gerard, Miller, Clint L., Owens, Gary K., Finn, Aloke, Navab, Mohamad, Fogelman, Alan M., Berliner, Judith A., Civelek, Mete

“…RATIONALE:Coronary artery disease (CAD) is a major cause of morbidity and mortality worldwide. Recent genome-wide association studies revealed 163 loci…”
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