Search Results - "Björhall, Karin"
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Comparison of different depletion strategies for improved resolution in proteomic analysis of human serum samples
Published in Proteomics (Weinheim) (01-01-2005)“…Serum proteins may often serve as indicators of disease and is a rich source for biomarker discovery. However, the large dynamic range of proteins in serum…”
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Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma
Published in Journal of medicinal chemistry (24-06-2021)“…Starting from our previously described PI3Kγ inhibitors, we describe the exploration of structure–activity relationships that led to the discovery of highly…”
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Measurement of serum C-reactive protein concentration for discriminating between suppurative arthritis and osteoarthritis in dogs
Published in BMC veterinary research (28-10-2016)“…In a dog with joint pain, it is important to determine whether it has suppurative joint disease, characterized by exudation of neutrophils in the synovial…”
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Selective Janus kinase 1 inhibition resolves inflammation and restores hair growth offering a viable treatment option for alopecia areata
Published in Skin health and disease (01-06-2023)“…Background Janus Kinase (JAK) inhibition has recently demonstrated therapeutic efficacy in both restoring hair growth and resolving inflammation in Alopecia…”
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Design and Synthesis of Soluble and Cell-Permeable PI3Kδ Inhibitors for Long-Acting Inhaled Administration
Published in Journal of medicinal chemistry (22-06-2017)“…PI3Kδ is a lipid kinase that is believed to be important in the migration and activation of cells of the immune system. Inhibition is hypothesized to provide a…”
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Transcriptional Dynamics of NRF2 Overexpression and KEAP1-NRF2 Inhibitors in Human Cell Line and Primary Lung Cells
Published in Antioxidants (30-07-2024)“…Oxidative stress in the human lung is caused by both internal (e.g., inflammation) and external stressors (smoking, pollution, and infection) to drive…”
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First Crystal Structure of Rubisco from a Green Alga,Chlamydomonas reinhardtii
Published in The Journal of biological chemistry (21-12-2001)“…The crystal structure of Rubisco (ribulose 1,5-bisphosphate carboxylase/oxygenase) from the unicellular green alga Chlamydomonas reinhardtii has been…”
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