Search Results - "Biverstal, Henrik"

Functionalization of amyloid fibrils via the Bri2 BRICHOS domain by Biverstål, Henrik, Kumar, Rakesh, Schellhaus, Anna Katharina, Sarr, Médoune, Dantuma, Nico P., Abelein, Axel, Johansson, Jan

“…Amyloid fibrils are mechanically robust and partly resistant to proteolytic degradation, making them potential candidates for scaffold materials in cell…”
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Food protein-derived amyloids do not accelerate amyloid β aggregation by Rahman, M. Mahafuzur, Pires, Rodrigo Sanches, Herneke, Anja, Gowda, Vasantha, Langton, Maud, Biverstål, Henrik, Lendel, Christofer

“…The deposition of proteins in the form of amyloid fibrils is closely associated with several serious diseases. The events that trigger the conversion from…”
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Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity by Aleksis, Rihards, Oleskovs, Filips, Jaudzems, Kristaps, Pahnke, Jens, Biverstål, Henrik

“…Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases worldwide. Formation of amyloid plaques consisting of amyloid-β peptides (Aβ)…”
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Stabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering by Sandberg, Anders, Luheshi, Leila M, Söllvander, Sofia, Pereira de Barros, Teresa, Macao, Bertil, Knowles, Tuomas P.J, Biverstål, Henrik, Lendel, Christofer, Ekholm-Petterson, Frida, Dubnovitsky, Anatoly, Lannfelt, Lars, Dobson, Christopher M, Härd, Torleif

“…Soluble oligomeric aggregates of the amyloid-β peptide (Aβ) have been implicated in the pathogenesis of Alzheimer's disease (AD). Although the conformation…”
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Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain by Kumar, Rakesh, Le Marchand, Tanguy, Adam, Laurène, Bobrovs, Raitis, Chen, Gefei, Fridmanis, Jēkabs, Kronqvist, Nina, Biverstål, Henrik, Jaudzems, Kristaps, Johansson, Jan, Pintacuda, Guido, Abelein, Axel

“…Protein misfolding can generate toxic intermediates, which underlies several devastating diseases, such as Alzheimer’s disease (AD). The surface of…”
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High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain by Abelein, Axel, Chen, Gefei, Kitoka, Kristīne, Aleksis, Rihards, Oleskovs, Filips, Sarr, Médoune, Landreh, Michael, Pahnke, Jens, Nordling, Kerstin, Kronqvist, Nina, Jaudzems, Kristaps, Rising, Anna, Johansson, Jan, Biverstål, Henrik

“…During storage in the silk gland, the N-terminal domain (NT) of spider silk proteins (spidroins) keeps the aggregation-prone repetitive region in solution at…”
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Pro-resolving lipid mediator reduces amyloid-β42-induced gene expression in human monocyte-derived microglia by Wang, Ying, Zhang, Xiang, Biverstål, Henrik, Bazan, Nicolas G, Tan, Shuai, Li, Nailin, Ohshima, Makiko, Schultzberg, Marianne, Li, Xiaofei

“…JOURNAL/nrgr/04.03/01300535-202503000-00031/figure1/v/2024-06-17T092413Z/r/image-tiff Specialized pro-resolving lipid mediators including maresin 1 mediate…”
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Identification of cytoskeletal proteins as binding partners of Bri2 BRICHOS domain by Shimozawa, Makoto, Tigro, Helene, Biverstål, Henrik, Shevchenko, Ganna, Bergquist, Jonas, Moaddel, Ruin, Johansson, Jan, Nilsson, Per

“…Proteins must fold into three-dimensional structures to execute their biological functions. Therefore, maintenance of protein homeostasis, proteostasis,…”
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Molecular Structure of Cu(II)-Bound Amyloid‑β Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer’s Disease by Abelein, Axel, Ciofi-Baffoni, Simone, Mörman, Cecilia, Kumar, Rakesh, Giachetti, Andrea, Piccioli, Mario, Biverstål, Henrik

“…Metal ions, such as copper and zinc ions, have been shown to strongly modulate the self-assembly of the amyloid-β (Aβ) peptide into insoluble fibrils, and…”
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Amyloid-β-induced action potential desynchronization and degradation of hippocampal gamma oscillations is prevented by interference with peptide conformation change and aggregation by Kurudenkandy, Firoz Roshan, Zilberter, Misha, Biverstål, Henrik, Presto, Jenny, Honcharenko, Dmytro, Strömberg, Roger, Johansson, Jan, Winblad, Bengt, Fisahn, André

“…The amyloid-β hypothesis of Alzheimer's Disease (AD) focuses on accumulation of amyloid-β peptide (Aβ) as the main culprit for the myriad physiological changes…”
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BRICHOS Domains Efficiently Delay Fibrillation of Amyloid β-Peptide by Willander, Hanna, Presto, Jenny, Askarieh, Glareh, Biverstål, Henrik, Frohm, Birgitta, Knight, Stefan D., Johansson, Jan, Linse, Sara

“…Amyloid diseases such as Alzheimer, Parkinson, and prion diseases are associated with a specific form of protein misfolding and aggregation into oligomers and…”
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Blood–brain and blood–cerebrospinal fluid passage of BRICHOS domains from two molecular chaperones in mice by Tambaro, Simone, Galan-Acosta, Lorena, Leppert, Axel, Chen, Gefei, Biverstål, Henrik, Presto, Jenny, Nilsson, Per, Johansson, Jan

“…Targeting toxicity associated with β-amyloid (Aβ) misfolding and aggregation is a promising therapeutic strategy for preventing or managing Alzheimer's…”
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Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation by Nagaraj, Madhu, Najarzadeh, Zahra, Pansieri, Jonathan, Biverstål, Henrik, Musteikyte, Greta, Smirnovas, Vytautas, Matthews, Steve, Emanuelsson, Cecilia, Johansson, Janne, Buxbaum, Joel N, Morozova-Roche, Ludmilla, Otzen, Daniel E

“…Unlike misfolding in neurodegenerative diseases, aggregation of functional amyloids involved in bacterial biofilm, e.g. CsgA ( E. coli ) and FapC ( Pseudomonas…”
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Specific inhibition of α‐synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS by Adam, Laurène, Kumar, Rakesh, Arroyo‐Garcia, Luis Enrique, Molenkamp, Willem Hendrik, Nowak, Jan Stanislaw, Klute, Hannah, Farzadfard, Azad, Alkenayeh, Rami, Nielsen, Janni, Biverstål, Henrik, Otzen, Daniel E., Johansson, Jan, Abelein, Axel

“…Protein misfolding and aggregation are involved in several neurodegenerative disorders, such as α‐synuclein (αSyn) implicated in Parkinson's disease, where new…”
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Dementia-related Bri2 BRICHOS is a versatile molecular chaperone that efficiently inhibits Aβ42 toxicity in Drosophila by Poska, Helen, Haslbeck, Martin, Kurudenkandy, Firoz Roshan, Hermansson, Erik, Chen, Gefei, Kostallas, George, Abelein, Axel, Biverstål, Henrik, Crux, Sophie, Fisahn, André, Presto, Jenny, Johansson, Jan

“…Formation of fibrils of the amyloid-β peptide (Aβ) is suggested to play a central role in neurodegeneration in Alzheimer's disease (AD), for which no effective…”
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Amyloid Fibril Formation of Arctic Amyloid‑β 1–42 Peptide is Efficiently Inhibited by the BRICHOS Domain by Zhong, Xueying, Kumar, Rakesh, Wang, Yu, Biverstål, Henrik, Ingeborg Jegerschöld, Caroline, J B Koeck, Philip, Johansson, Jan, Abelein, Axel, Chen, Gefei

“…Amyloid-β peptide (Aβ) aggregation is one of the hallmarks of Alzheimer’s disease (AD). Mutations in Aβ are associated with early onset familial AD, and the…”
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High intracellular stability of the spidroin N‐terminal domain in spite of abundant amyloidogenic segments revealed by in‐cell hydrogen/deuterium exchange mass spectrometry by Kaldmäe, Margit, Leppert, Axel, Chen, Gefei, Sarr, Medoune, Sahin, Cagla, Nordling, Kerstin, Kronqvist, Nina, Gonzalvo‐Ulla, Marta, Fritz, Nicolas, Abelein, Axel, Laίn, Sonia, Biverstål, Henrik, Jörnvall, Hans, Lane, David P., Rising, Anna, Johansson, Jan, Landreh, Michael

“…Proteins require an optimal balance of conformational flexibility and stability in their native environment to ensure their biological functions. A striking…”
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Amyloid‑β Peptide Targeting Peptidomimetics for Prevention of Neurotoxicity by Honcharenko, Dmytro, Juneja, Alok, Roshan, Firoz, Maity, Jyotirmoy, Galán-Acosta, Lorena, Biverstål, Henrik, Hjorth, Erik, Johansson, Jan, Fisahn, André, Nilsson, Lennart, Strömberg, Roger

“…A new generation of ligands designed to interact with the α-helix/β-strand discordant region of the amyloid-β peptide (Aβ) and to counteract its…”
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Molecular Chaperone BRICHOS Inhibits CADASIL-Mutated NOTCH3 Aggregation In Vitro by Oliveira, Daniel V, Svensson, Julia, Zhong, Xueying, Biverstål, Henrik, Chen, Gefei, Karlström, Helena

“…CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is the most common familial form of stroke, which is…”
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Dissociation of a BRICHOS trimer into monomers leads to increased inhibitory effect on Aβ42 fibril formation by Biverstål, Henrik, Dolfe, Lisa, Hermansson, Erik, Leppert, Axel, Reifenrath, Mara, Winblad, Bengt, Presto, Jenny, Johansson, Jan

“…The BRICHOS domain is associated with human amyloid disease, and it efficiently prevents amyloid fibril formation of the amyloid β-peptide (Aβ) in vitro and in…”
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