Search Results - "Bitton, A"

A deep learning genome-mining strategy for biosynthetic gene cluster prediction by Hannigan, Geoffrey D, Prihoda, David, Palicka, Andrej, Soukup, Jindrich, Klempir, Ondrej, Rampula, Lena, Durcak, Jindrich, Wurst, Michael, Kotowski, Jakub, Chang, Dan, Wang, Rurun, Piizzi, Grazia, Temesi, Gergely, Hazuda, Daria J, Woelk, Christopher H, Bitton, Danny A

“…Abstract Natural products represent a rich reservoir of small molecule drug candidates utilized as antimicrobial drugs, anticancer therapies, and…”
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BioPhi: A platform for antibody design, humanization, and humanness evaluation based on natural antibody repertoires and deep learning by Prihoda, David, Maamary, Jad, Waight, Andrew, Juan, Veronica, Fayadat-Dilman, Laurence, Svozil, Daniel, Bitton, Danny A

“…Despite recent advances in transgenic animal models and display technologies, humanization of mouse sequences remains one of the main routes for therapeutic…”
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Predicting relapse in Crohn's disease: a biopsychosocial model by Bitton, A, Dobkin, P L, Edwardes, M D, Sewitch, M J, Meddings, J B, Rawal, S, Cohen, A, Vermeire, S, Dufresne, L, Franchimont, D, Wild, G E

“…Crohn's disease (CD) is a chronic relapsing inflammatory bowel disorder. Both biological and psychosocial factors may modulate the illness experience. The aim…”
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Review article: defining remission in ulcerative colitis by Travis, S. P. L., Higgins, P. D. R., Orchard, T., Van Der Woude, C. J., Panaccione, R., Bitton, A., O’Morain, C., Panés, J., Sturm, A., Reinisch, W., Kamm, M. A., D’Haens, G.

“…Aliment Pharmacol Ther 2011; 34: 113–124 Summary Background  There is no international agreement on scoring systems used to measure disease activity in…”
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Subcutaneous ustekinumab for the treatment of anti-TNF resistant Crohn's disease—The McGill experience by Kopylov, U., Afif, W., Cohen, A., Bitton, A., Wild, G., Bessissow, T., Wyse, J., Al-Taweel, T., Szilagyi, A., Seidman, E.

“…Ustekinumab is a fully human IgG1κ monoclonal antibody that blocks the biologic activity of interleukin-12/23. Ustekinumab is approved for treatment of plaque…”
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The genomic and phenotypic diversity of Schizosaccharomyces pombe by Jeffares, Daniel C, Rallis, Charalampos, Rieux, Adrien, Speed, Doug, Převorovský, Martin, Mourier, Tobias, Marsellach, Francesc X, Iqbal, Zamin, Lau, Winston, Cheng, Tammy M K, Pracana, Rodrigo, Mülleder, Michael, Lawson, Jonathan L D, Chessel, Anatole, Bala, Sendu, Hellenthal, Garrett, O'Fallon, Brendan, Keane, Thomas, Simpson, Jared T, Bischof, Leanne, Tomiczek, Bartlomiej, Bitton, Danny A, Sideri, Theodora, Codlin, Sandra, Hellberg, Josephine E E U, van Trigt, Laurent, Jeffery, Linda, Li, Juan-Juan, Atkinson, Sophie, Thodberg, Malte, Febrer, Melanie, McLay, Kirsten, Drou, Nizar, Brown, William, Hayles, Jacqueline, Salas, Rafael E Carazo, Ralser, Markus, Maniatis, Nikolas, Balding, David J, Balloux, Francois, Durbin, Richard, Bähler, Jürg

“…Daniel Jeffares, Jürg Bähler and colleagues report the genome sequences of 161 natural isolates of Schizosaccharomyces pombe , finding moderate genetic…”
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Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast by Atkinson, Sophie R, Marguerat, Samuel, Bitton, Danny A, Rodríguez-López, Maria, Rallis, Charalampos, Lemay, Jean-François, Cotobal, Cristina, Malecki, Michal, Smialowski, Pawel, Mata, Juan, Korber, Philipp, Bachand, François, Bähler, Jürg

“…Long noncoding RNAs (lncRNAs), which are longer than 200 nucleotides but often unstable, contribute a substantial and diverse portion to pervasive noncoding…”
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Survey of reproduction management on Canadian dairy farms by Denis-Robichaud, J, Cerri, R L A, Jones-Bitton, A, LeBlanc, S J

“…The objectives of this study were to (1) quantify current reproduction management practices, and (2) assess the association between these practices and herd…”
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A machine learning strategy for the identification of key in silico descriptors and prediction models for IgG monoclonal antibody developability properties by Waight, Andrew B., Prihoda, David, Shrestha, Rojan, Metcalf, Kevin, Bailly, Marc, Ancona, Marco, Widatalla, Talal, Rollins, Zachary, Cheng, Alan C, Bitton, Danny A., Fayadat-Dilman, Laurence

“…Identification of favorable biophysical properties for protein therapeutics as part of developability assessment is a crucial part of the preclinical…”
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Functional and regulatory profiling of energy metabolism in fission yeast by Malecki, Michal, Bitton, Danny A, Rodríguez-López, Maria, Rallis, Charalampos, Calavia, Noelia Garcia, Smith, Graeme C, Bähler, Jürg

“…The control of energy metabolism is fundamental for cell growth and function and anomalies in it are implicated in complex diseases and ageing. Metabolism in…”
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The Canadian National Dairy Study 2015-Adoption of milking practices in Canadian dairy herds by Belage, E, Dufour, S, Bauman, C, Jones-Bitton, A, Kelton, D F

“…Several studies have investigated which management practices have the greatest effect on udder health, but little information is available on how broadly the…”
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AnGeLi: A Tool for the Analysis of Gene Lists from Fission Yeast by Bitton, Danny A, Schubert, Falk, Dey, Shoumit, Okoniewski, Michal, Smith, Graeme C, Khadayate, Sanjay, Pancaldi, Vera, Wood, Valerie, Bähler, Jürg

“…Genome-wide assays and screens typically result in large lists of genes or proteins. Enrichments of functional or other biological properties within such lists…”
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Cost-benefit of implementing a participatory extension model for improving on-farm adoption of Johne's disease control recommendations by Roche, S M, Von Massow, M, Renaud, D, Shock, D A, Jones-Bitton, A, Kelton, D F

“…The objective of this study was to perform a cost-benefit analysis (CBA) of a participatory extension model, called Ontario Focus Farms (FF), which was…”
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What's in a Name? The Incorrect Use of Case Series as a Study Design Label in Studies Involving Dogs and Cats by Sargeant, J.M., O'Connor, A.M., Cullen, J.N., Makielski, K.M., Jones‐Bitton, A.

“…Background Study design labels are used to identify relevant literature to address specific clinical and research questions and to aid in evaluating the…”
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LaSSO, a strategy for genome-wide mapping of intronic lariats and branch points using RNA-seq by Bitton, Danny A, Rallis, Charalampos, Jeffares, Daniel C, Smith, Graeme C, Chen, Yuan Y C, Codlin, Sandra, Marguerat, Samuel, Bähler, Jürg

“…Both canonical and alternative splicing of RNAs are governed by intronic sequence elements and produce transient lariat structures fastened by branch points…”
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Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy : evidence for inappropriate insulin secretion and pancreatic islet hyperplasia by PATTI, M. E, MCMAHON, G, BONNER-WEIR, S, GOLDFINE, A. B, MUN, E. C, BITTON, A, HOIST, J. J, GOLDSMITH, J, HANTO, D. W, GALLERY, M, ARKY, R, NOSE, V

“…Postprandial hypoglycaemia following gastric bypass for obesity is considered a late manifestation of the dumping syndrome and can usually be managed with…”
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Evaluating the effect of Focus Farms on Ontario dairy producers' knowledge, attitudes, and behavior toward control of Johne's disease by Roche, S M, Jones-Bitton, A, Meehan, M, Von Massow, M, Kelton, D F

“…This study evaluated a participatory-based, experiential learning program, Ontario Focus Farms (FF), which aimed to change dairy producer behavior to control…”
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Eight-channel iTRAQ Enables Comparison of the Activity of Six Leukemogenic Tyrosine Kinases by Pierce, Andrew, Unwin, Richard D., Evans, Caroline A., Griffiths, Stephen, Carney, Louise, Zhang, Liqun, Jaworska, Ewa, Lee, Chia-Fang, Blinco, David, Okoniewski, Michal J., Miller, Crispin J., Bitton, Danny A., Spooncer, Elaine, Whetton, Anthony D.

“…There are a number of leukemogenic protein-tyrosine kinases (PTKs) associated with leukemic transformation. Although each is linked with a specific disease…”
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A systematic review and meta-analysis of factors associated with anthelmintic resistance in sheep by Falzon, L.C., O’Neill, T.J., Menzies, P.I., Peregrine, A.S., Jones-Bitton, A., vanLeeuwen, J., Mederos, A.

“…Anthelmintic drugs have been widely used in sheep as a cost-effective means for gastro-intestinal nematode (GIN) control. However, growing anthelmintic…”
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Review article: a clinician's guide for therapeutic drug monitoring of infliximab in inflammatory bowel disease by Khanna, R., Sattin, B. D., Afif, W., Benchimol, E. I., Bernard, E.‐J., Bitton, A., Bressler, B., Fedorak, R. N., Ghosh, S., Greenberg, G. R., Marshall, J. K., Panaccione, R., Seidman, E. G., Silverberg, M. S., Steinhart, A. H., Sy, R., Van Assche, G., Walters, T. D., Sandborn, W. J., Feagan, B. G.

“…Summary Background Tumour necrosis factor (TNF)‐antagonists have an established role in the treatment of inflammatory bowel diseases (IBDs), however,…”
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