Search Results - "Bittencourt, Paulo Ivo Homem de"

Oral free and dipeptide forms of glutamine supplementation attenuate oxidative stress and inflammation induced by endotoxemia by Cruzat, Vinicius Fernandes, Ph.D, Bittencourt, Aline, B.Ph.Ed, Scomazzon, Sofia Pizzato, B.Biomed, Leite, Jaqueline Santos Moreira, B.Nutr, de Bittencourt, Paulo Ivo Homem, Ph.D, Tirapegui, Julio, Ph.D

“…Abstract Objective The aim of the present study was to determine the effects of oral supplementation with l -glutamine plus l -alanine (GLN+ALA), both in the…”
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Molecular mechanisms of ROS production and oxidative stress in diabetes by Newsholme, Philip, Cruzat, Vinicius Fernandes, Keane, Kevin Noel, Carlessi, Rodrigo, de Bittencourt, Jr, Paulo Ivo Homem

“…Oxidative stress and chronic inflammation are known to be associated with the development of metabolic diseases, including diabetes. Oxidative stress, an…”
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The Chaperone Balance Hypothesis: The Importance of the Extracellular to Intracellular HSP70 Ratio to Inflammation-Driven Type 2 Diabetes, the Effect of Exercise, and the Implications for Clinical Management by Homem de Bittencourt, Paulo Ivo, Newsholme, Philip, Scomazzon, Sofia Pizzato, Bittencourt, Aline, Heck, Thiago Gomes, Krause, Mauricio, Curi, Rui

“…Recent evidence shows divergence between the concentrations of extracellular 70 kDa heat shock protein [eHSP70] and its intracellular concentrations [iHSP70]…”
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Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β-Cell Dysfunction by Homem de Bittencourt, Paulo Ivo, Carlessi, Rodrigo, Cruzat, Vinicius Fernandes, Keane, Kevin N., Newsholme, Philip

“…The prevalence of diabetes mellitus (DM) is increasing worldwide, a consequence of the alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress…”
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Effects of n-3 fatty acids and exercise on oxidative stress parameters in type 2 diabetic: a randomized clinical trial by Fayh, Ana Paula Trussardi, Borges, Katiuce, Cunha, Giovani Santos, Krause, Mauricio, Rocha, Ricardo, de Bittencourt, Jr, Paulo Ivo Homem, Moreira, José Cláudio Fonseca, Friedman, Rogério, da Silva Rossato, Juliane, Fernandes, Jõao Roberto, Reischak-Oliveira, Alvaro

“…The relationship between diabetes and oxidative stress has been previously reported. Exercise represents a useful non-pharmacological strategy for the…”
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The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes by Krause, Mauricio, Bock, Patricia Martins, Takahashi, Hilton Kenji, Homem De Bittencourt, Jr, Paulo Ivo, Newsholme, Philip

“…The 70 kDa heat-shock protein (HSP70) family is important for a dynamic range of cellular processes that include protection against cell stress, modulation of…”
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Obesity depresses the anti‐inflammatory HSP70 pathway, contributing to NAFLD progression by Cangeri Di Naso, Fábio, Rosa Porto, Rossana, Sarubbi Fillmann, Henrique, Maggioni, Lucas, Vontobel Padoin, Alexandre, Jacques Ramos, Rafael, Corá Mottin, Claudio, Bittencourt, Aline, Anair Possa Marroni, Norma, Ivo Homem de Bittencourt, Paulo

“…Objectives To evaluate whether reduced activity of the anti‐inflammatory HSP70 pathway correlates with nonalcoholic fatty liver disease (NAFLD) progression and…”
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The dance of proteostasis and metabolism: Unveiling the caloristatic controlling switch by Schroeder, Helena Trevisan, De Lemos Muller, Carlos Henrique, Heck, Thiago Gomes, Krause, Mauricio, de Bittencourt, Paulo Ivo Homem

“…The heat shock response (HSR) is an ancient and evolutionarily conserved mechanism designed to restore cellular homeostasis following proteotoxic challenges…”
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Chronic whole-body heat treatment relieves atherosclerotic lesions, cardiovascular and metabolic abnormalities, and enhances survival time restoring the anti-inflammatory and anti-senescent heat shock response in mice by Bruxel, Maciel Alencar, Tavares, Angela Maria Vicente, Zavarize Neto, Luiz Domingues, de Souza Borges, Victor, Schroeder, Helena Trevisan, Bock, Patricia Martins, Rodrigues, Maria Inês Lavina, Belló-Klein, Adriane, Homem de Bittencourt, Paulo Ivo

“…Unhealthy lifestyle persistently feeds forward inflammation in metabolic organs thus imposing senescence-associated secretory phenotype (SASP), as observed in…”
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Comparative study on the influence of the content and functionalization of alginate matrices on K-562 cell viability and differentiation by Morais, Everton C., Schroeder, Helena T., Souza, Cristina S., Rodrigues, Silvia R., Rodrigues, Maria Ines L., de Bittencourt, Paulo Ivo Homem, Santos, João Henrique Z. Dos

“…Microencapsulation of functioning cells for transplantation therapies is particularly promising, but the cells must retain their proper physiology and…”
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L-glutamine supplementations enhance liver glutamine-glutathione axis and heat shock factor-1 expression in endurance-exercise trained rats by Petry, Éder Ricardo, Cruzat, Vinicius Fernandes, Heck, Thiago Gomes, Homem de Bittencourt, Jr, Paulo Ivo, Tirapegui, Julio

“…Liver L-glutamine is an important vehicle for the transport of ammonia and intermediary metabolism of amino acids between tissues, particularly under catabolic…”
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The oxidation of HSP70 is associated with functional impairment and lack of stimulatory capacity by Grunwald, Marcelo Sartori, Pires, André Simões, Zanotto-Filho, Alfeu, Gasparotto, Juciano, Gelain, Daniel Pens, Demartini, Diogo Ribeiro, Schöler, Cinthia Maria, de Bittencourt, Paulo Ivo Homem, Moreira, José Cláudio Fonseca

“…Expression of intracellular HSP70 is associated with cytoprotective effects against a wide range of stressful stimuli, such as inflammation, oxidative stress,…”
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Chronic heat treatment positively impacts metabolic profile of ovariectomized rats: association with heat shock response pathways by Lissarassa, Yana Picinin Sandri, Vincensi, Carolain Felipin, Costa-Beber, Lílian Corrêa, dos Santos, Analú Bender, Goettems-Fiorin, Pauline Brendler, dos Santos, Jaíne Borges, Donato, Yohanna Hannnah, Wildner, Guilherme, de Bittencourt Júnior, Paulo Ivo Homem, Frizzo, Matias Nunes, Heck, Thiago Gomes, Ludwig, Mirna Stela

“…Low estrogen levels may predispose women to increased bodyweight and dyslipidemia. Previous studies from our laboratory suggest an involvement of depressed…”
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GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation by Carlessi, Rodrigo, Chen, Younan, Rowlands, Jordan, Cruzat, Vinicius F., Keane, Kevin N., Egan, Lauren, Mamotte, Cyril, Stokes, Rebecca, Gunton, Jenny E., Bittencourt, Paulo Ivo Homem de, Newsholme, Philip

“…Glucagon-like peptide-1 (GLP-1) promotes insulin secretion from pancreatic β-cells in a glucose dependent manner. Several pathways mediate this action by…”
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Heat shock response in noise-induced hearing loss: effects of alanyl-glutamine dipeptide supplementation on heat shock proteins status by Soares, Marcos, Santos, Analu B. dos, Weich, Tainara M., Mânica, Gabriela Gomes, Homem de Bittencourt, Paulo Ivo, Ludwig, Mirna Stela, Heck, Thiago Gomes

“…The 72kDa heat shock protein, HSP72, located intracellularly provides cochlear cytoprotective and anti-inflammatory roles in the inner ear during stressful…”
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Nitric oxide-heat shock protein axis in menopausal hot flushes: neglected metabolic issues of chronic inflammatory diseases associated with deranged heat shock response by Miragem, Antônio Azambuja, Homem de Bittencourt, Jr, Paulo Ivo

“…Although some unequivocal underlying mechanisms of menopausal hot flushes have been demonstrated in animal models, the paucity of similar approaches in humans…”
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Regulatory principles in metabolism-then and now by Curi, Rui, Newsholme, Philip, Marzuca-Nassr, Gabriel Nasri, Takahashi, Hilton Kenji, Hirabara, Sandro Massao, Cruzat, Vinicius, Krause, Mauricio, de Bittencourt, Jr, Paulo Ivo Homem

“…The importance of metabolic pathways for life and the nature of participating reactions have challenged physiologists and biochemists for over a hundred years…”
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Resolution of inflammation in chronic disease via restoration of the heat shock response (HSR) by Schroeder, Helena Trevisan, De Lemos Muller, Carlos Henrique, Heck, Thiago Gomes, Krause, Mauricio, de Bittencourt, Paulo Ivo Homem

“…Effective resolution of inflammation via the heat shock response (HSR) is pivotal in averting the transition to chronic inflammatory states. This transition…”
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Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies by Heck, Thiago Gomes, Ludwig, Mirna Stela, Frizzo, Matias Nunes, Rasia-Filho, Alberto Antonio, Homem de Bittencourt, Paulo Ivo

“…The major risk factors to fatal outcome in COVID-19 patients, i.e., elderliness and pre-existing metabolic and cardiovascular diseases (CVD), share in common…”
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Alanyl-glutamine and glutamine plus alanine supplements improve skeletal redox status in trained rats: Involvement of heat shock protein pathways by Petry, Éder Ricardo, Cruzat, Vinicius Fernandes, Heck, Thiago Gomes, Leite, Jaqueline Santos Moreira, Homem de Bittencourt, Paulo Ivo, Tirapegui, Julio

“…We hypothesized that oral l-glutamine supplementations could attenuate muscle damage and oxidative stress, mediated by glutathione (GSH) in high-intensity…”
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