Biological studies on Brazilian plants used in wound healing

n-Hexanic and ethanolic extracts from twelve plants ( Brugmansia suaveolens Brecht. et Presl., Eupatorium laevigatum Lam., Galinsoga parviflora Cav., Iresine herbstii Hook., Kalanchöe tubiflora Hamet-Ahti, Petiveria alliacea L., Pluchea sagittalis (Lam.) Cabrera, Piper regnellii DC., Schinus molle L...

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Bibliographic Details
Published in:	Journal of ethnopharmacology Vol. 122; no. 3; pp. 523 - 532
Main Authors:	Schmidt, C., Fronza, M., Goettert, M., Geller, F., Luik, S., Flores, E.M.M., Bittencourt, C.F., Zanetti, G.D., Heinzmann, B.M., Laufer, S., Merfort, I.
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 21-04-2009 Elsevier
Subjects:	Animals Anti-Bacterial Agents - pharmacology Biological and medical sciences Brazil Brazilian medicinal plants Caspase 3 - metabolism Cell Line Cytotoxins - pharmacology Eupatorium Fibroblasts - drug effects Galinsoga parviflora General pharmacology Humans Iresine herbstii Magnoliopsida Medical sciences Medicine, Traditional Mice Microbial Sensitivity Tests NF-kappa B - genetics NF-kappa B - metabolism NF-κB p38 Mitogen-Activated Protein Kinases - metabolism p38α MAPK Pancreatic Elastase - metabolism Petiveria alliacea Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Piper regnellii Plant Extracts - pharmacology Plant Extracts - therapeutic use Plants, Medicinal Pluchea Schinus molle Sedum TNF-α Tumor Necrosis Factor-alpha - metabolism Waltheria Wound healing Wound Healing - drug effects Wound Healing - physiology Xanthium South America Brazil America NF-κB Wound healing TNF-α Brazilian medicinal plants p38α MAPK Enzyme Pharmacognosy Transferases Cytokine Mitogen-activated protein kinase Wound Medicinal plant Healing agent Plant origin Transcription factor NFκB Tumor necrosis factor α
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Summary:	n-Hexanic and ethanolic extracts from twelve plants ( Brugmansia suaveolens Brecht. et Presl., Eupatorium laevigatum Lam., Galinsoga parviflora Cav., Iresine herbstii Hook., Kalanchöe tubiflora Hamet-Ahti, Petiveria alliacea L., Pluchea sagittalis (Lam.) Cabrera, Piper regnellii DC., Schinus molle L., Sedum dendroideum Moç et Sessé ex DC., Waltheria douradinha St. Hill., Xanthium cavanillesii Schouw.) used in traditional South Brazilian medicine as wound healing agents were investigated in various biological assays, targeting different aspects in this complex process. The extracts were investigated on NF-κB DNA binding, p38α MAPK, TNF-α release, direct elastase inhibition and its release as well as on caspase-3. Fibroblasts migration to and proliferation into the wounded monolayers were evaluated in the scratch assay, the agar diffusion test for antibacterial and the MTT assay for cytotoxic effects. The hydrophilic extracts from Galinsoga parviflora, Petiveria alliacea, Schinus molle, Waltheria douradinha and Xanthium cavanillesii as well as the lipophilic extract of Waltheria douradinha turned out to be the most active ones. These results increase our knowledge on the wound healing effects of the investigated medicinal plants. Further studies are necessary to find out the effective secondary metabolites responsible for the observed effects.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0378-8741 1872-7573
DOI:	10.1016/j.jep.2009.01.022