Search Results - "Bitensky, M. W"

Extended storage of red blood cells under anaerobic conditions by Yoshida, T., AuBuchon, J. P., Tryzelaar, L., Foster, K. Y., Bitensky, M. W.

“…Background  Red blood cells (RBC) are subject to oxidative stress by reactive oxygen species during refrigerated storage. Near‐complete removal of oxygen from…”
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Rethinking the Role of Phosducin: Light-Regulated Binding of Phosducin to 14-3-3 in Rod Inner Segments by Nakano, Koichi, Chen, Jing, Tarr, George E., Yoshida, Tatsuro, Flynn, Julia M., Bitensky, Mark W.

“…Phosducin (Pd), a small protein found abundantly in photoreceptors, is widely assumed to regulate light sensitivity in the rod outer segment through…”
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The phosphorylation state of phosducin determines its ability to block transducin subunit interactions and inhibit transducin binding to activated rhodopsin by Yoshida, T, Willardson, B M, Wilkins, J F, Jensen, G J, Thornton, B D, Bitensky, M W

“…Heterotrimeric GTP-binding proteins (G-proteins) serve many different signal transduction pathways. Phosducin, a 28-kDa phosphoprotein, is expressed in a…”
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Reversible Sodium Pump Defect and Swelling in the Diabetic Rat Erythrocyte: Effects on Filterability and Implications for Microangiopathy by Kowluru, R., Bitensky, M. W., Kowluru, A., Dembo, M., Keaton, P. A., Buican, T.

“…We have found a defect in the ouabain-sensitive Na+,K+-ATPase (Na+pump, EC 3.6.1.37) of erythrocytes from streptozotocin diabetic rats. This defect was…”
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Cooperative binding of the retinal rod G-protein, transducin, to light-activated rhodopsin by WILLARDSON, B. M, POU, B, YOSHIDA, T, BITENSKY, M. W

“…Direct measurements of the binding between light-activated rhodopsin (Rho*) and transducin, the retinal rod G-protein, revealed a strongly cooperative…”
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Interactions between the subunits of transducin and cyclic GMP phosphodiesterase in Rana catesbiana rod photoreceptors by YAMAZAKI, A, HAYASHI, F, TATSUMI, M, BITENSKY, M. W, GEORGE, J. S

“…In bullfrog (Rana catesbiana) rods the activity of cyclic GMP (cGMP) phosphodiesterase was stimulated 10 times by washing disc membranes with an isotonic,…”
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Characterization by two-dimensional peptide mapping of the gamma subunits of Ns and Ni, the regulatory proteins of adenylyl cyclase, and of transducin, the guanine nucleotide-binding protein of rod outer segments of the eye by Hildebrandt, J D, Codina, J, Rosenthal, W, Birnbaumer, L, Neer, E J, Yamazaki, A, Bitensky, M W

“…Ns and Ni, the regulatory proteins affecting adenylyl cyclase, and transducin, the guanine nucleotide-binding protein from rod outer segments of the eye, are…”
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Activation mechanism of rod outer segment cyclic GMP phosphodiesterase. Release of inhibitor by the GTP/GTP-binding protein by Yamazaki, A, Stein, P J, Chernoff, N, Bitensky, M W

“…The physiological regulation of light-activated cyclic GMP phosphodiesterase (EC 3.1.4.17) in rod outer segments has been shown to depend upon a heat-stable…”
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The GTP-binding protein of rod outer segments. I. Role of each subunit in the GTP hydrolytic cycle by Yamazaki, A, Tatsumi, M, Torney, D C, Bitensky, M W

“…The GTP-binding protein of Bufo marinus rod outer segments (ROS) is composed of 3 subunits: G alpha, 39,000; G beta, 36,000; and G gamma, approximately 6,500…”
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Comparison of the phosphodiesterase inhibitory subunit interactions of frog and bovine rod outer segments by Whalen, M M, Bitensky, M W

“…The rod outer segments of the bovine and frog retina possess a cyclic GMP phosphodiesterase (PDE) that is composed of two larger subunits, alpha and beta (P…”
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Structural and Functional Consequences of Increased Tubulin Glycosylation in Diabetes Mellitus by Williams, Stuart K., Howarth, Nancy L., Devenny, James J., Bitensky, Mark W.

“…The extent of in vitro nonenzymatic glycosylation of purified rat brain tubulin was dependent on time and glucose concentration. Tubulin glycosylation…”
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Purification and properties of the light-activated cyclic nucleotide phosphodiesterase of rod outer segments by Miki, N, Baraban, J M, Keirns, J J, Boyce, J J, Bitensky, M W

“…Frog (Rana catesbiana) rod outer segment disc membranes contain a cyclic nucleotide phosphodiesterase (EC 3.1.4.17) which is activated by light in the presence…”
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Glycation of calmodulin: chemistry and structural and functional consequences by Kowluru, R. A, Heidorn, D. B, Edmondson, S. P, Bitensky, M. W, Kowluru, A, Downer, N. W, Whaley, T. W, Trewhella, J

“…In the presence of Ca2+ and glucose, calmodulin incorporates 2.5 mol of glucose/mol of protein. In the absence of Ca2+, only 1.5 mol of glucose is incorporated…”
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Micropinocytic Ingestion of Glycosylated Albumin by Isolated Microvessels: Possible Role in Pathogenesis of Diabetic Microangiopathy by Williams, Stuart K., Devenny, James J., Bitensky, Mark W.

“…Microvessels isolated from rat epididymal fat exhibit differential vesicular ingestion rates for unmodified and nonenzymatically glycosylated rat albumin…”
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Reciprocal Effects of an Inhibitory Factor on Catalytic Activity and Noncatalytic cGMP Binding Sites of Rod Phosphodiesterase by Yamazaki, Akio, Bartucca, Francis, Ting, Alexander, Bitensky, Mark W.

“…In illuminated rod outer segment membranes, GTP and guanosine 5′-[β , γ -imido]triphosphate (p[NH]ppG) have reciprocal effects on cGMP phosphodiesterase…”
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Cyclic GMP-specific, high affinity, noncatalytic binding sites on light-activated phosphodiesterase by Yamazaki, A, Sen, I, Bitensky, M W, Casnellie, J E, Greengard, P

“…Two classes of high affinity, cGMP-specific binding sites have been found in association with a peripheral membrane protein in rod outer segments. [3H]cGMP and…”
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The GTP-binding protein of rod outer segments. II. An essential role for Mg2+ in signal amplification by Yamazaki, A, Bitensky, M W, Garcia-Sainz, J A

“…The role of Mg2+ in the GTP hydrolytic cycle was investigated by using purified subunits (G alpha and G beta, gamma) of the GTP-binding protein isolated from…”
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The effect of the gamma-subunit of the cyclic GMP phosphodiesterase of bovine and frog (Rana catesbiana) retinal rod outer segments on the kinetic parameters of the enzyme by Whalen, M M, Bitensky, M W, Takemoto, D J

“…Rod-outer-segment cyclic GMP phosphodiesterase (PDE) (subunit composition alpha beta gamma 2) contains catalytic activity in alpha beta. The gamma-subunits are…”
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A Light-Activated GTPase in Vertebrate Photoreceptors: Regulation of Light-Activated Cyclic GMP Phosphodiesterase by Wheeler, George L., Bitensky, Mark W.

“…We have been studying the mechanism by which light and nucleoside triphosphates activate the disc-membrane phosphodiesterase (oligonucleate…”
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Modulation of the G Protein Regulator Phosducin by Ca2+/Calmodulin-dependent Protein Kinase II Phosphorylation and 14-3-3 Protein Binding by Thulin, Craig D., Savage, Justin R., McLaughlin, Joseph N., Truscott, Steven M., Old, William M., Ahn, Natalie G., Resing, Katheryn A., Hamm, Heidi E., Bitensky, Mark W., Willardson, Barry M.

“…Phototransduction is a canonical G protein-mediated cascade of retinal photoreceptor cells that transforms photons into neural responses. Phosducin (Pd) is a…”
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