Search Results - "Biswas, Jeetayu"

An improved MS2 system for accurate reporting of the mRNA life cycle by Tutucci, Evelina, Vera, Maria, Biswas, Jeetayu, Garcia, Jennifer, Parker, Roy, Singer, Robert H

“…An improved MS2-tagging system for live-cell RNA imaging allows faithful monitoring of the mRNA life cycle, overcoming degradation artifacts associated with…”
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Single-Cell and Single-Molecule Analysis of Gene Expression Regulation by Vera, Maria, Biswas, Jeetayu, Senecal, Adrien, Singer, Robert H, Park, Hye Yoon

“…Recent advancements in single-cell and single-molecule imaging technologies have resolved biological processes in time and space that are fundamental to…”
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The structural basis for RNA selectivity by the IMP family of RNA-binding proteins by Biswas, Jeetayu, Patel, Vivek L., Bhaskar, Varun, Chao, Jeffrey A., Singer, Robert H., Eliscovich, Carolina

“…The IGF2 mRNA-binding proteins (ZBP1/IMP1, IMP2, IMP3) are highly conserved post-transcriptional regulators of RNA stability, localization and translation…”
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Fluorescence Imaging Methods to Investigate Translation in Single Cells by Biswas, Jeetayu, Liu, Yang, Singer, Robert H, Wu, Bin

“…Translation is the fundamental biological process that converts the genetic information in messenger RNAs (mRNAs) into functional proteins. Translation…”
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An improved MS2 system for accurate reporting of the mRNA life cycle by Tutucci, Evelina, Vera, Maria, Biswas, Jeetayu, Garcia, Jennifer, Parker, Roy, Singer, Robert H

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MS2-TRIBE Evaluates Both Protein-RNA Interactions and Nuclear Organization of Transcription by RNA Editing by Biswas, Jeetayu, Rahman, Reazur, Gupta, Varun, Rosbash, Michael, Singer, Robert H.

“…Both UV-cross-linking and immunoprecipitation (CLIP) and RNA editing (TRIBE) can identify the targets of RNA-binding proteins. To evaluate false-positives of…”
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Protocol for using TRIBE to study RNA-protein interactions and nuclear organization in mammalian cells by Biswas, Jeetayu, Rosbash, Michael, Singer, Robert H., Rahman, Reazur

“…Targets of RNA-binding proteins discovered by editing (TRIBE) determines RNA-proteins interactions and nuclear organization with minimal false positives. We…”
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A new SAGA for AML: targeting SGF29 in AML by Biswas, Jeetayu, Abdel-Wahab, Omar

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Aberrant pre-mRNA processing in cancer by Biswas, Jeetayu, Boussi, Leora, Stein, Eytan, Abdel-Wahab, Omar

“…Dysregulation of the flow of information from genomic DNA to RNA to protein occurs within all cancer types. In this review, we described the current state of…”
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Targeted RNA editing: novel tools to study post-transcriptional regulation by Xu, Weijin, Biswas, Jeetayu, Singer, Robert H., Rosbash, Michael

“…RNA binding proteins (RBPs) regulate nearly all post-transcriptional processes within cells. To fully understand RBP function, it is essential to identify…”
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Therapeutic strategies targeting aberrant RNA splicing in myeloid malignancies by Boussi, Leora, Biswas, Jeetayu, Abdel-Wahab, Omar, Stein, Eytan

“…In recent years, large-scale sequencing efforts have identified targetable driver mutations in haematopoietic stem cells. These efforts have led to the…”
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Imaging Organization of RNA Processing within the Nucleus by Biswas, Jeetayu, Li, Weihan, Singer, Robert H, Coleman, Robert A

“…Within the nucleus, messenger RNA is generated and processed in a highly organized and regulated manner. Messenger RNA processing begins during transcription…”
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Conformational heterogeneity suggests multiple substrate binding modes in CYP106A2 by Wong, Nathan R., Sundar, Reethy, Kazanis, Sophia, Biswas, Jeetayu, Pochapsky, Thomas C.

“…CYP106A2 (cytochrome P450meg) is a bacterial enzyme originally isolated from B. megaterium, and has been shown to hydroxylate a wide variety of substrates,…”
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Genome-Wide Mapping of R-Loops in Single Cells Reveals Cell-Type Specific Roles for R-Loops in Hematopoietic Cell Identity by Lu, Bin, Zhang, Pu, Chen, Sisi, Benbarche, Salima, Castro, Cynthia, Fox, Nina, Abubakar, Mohammad, Biswas, Jeetayu, Soldatov, Ruslan, Koche, Richard, Abdel-Wahab, Omar

“…R-loops are three-stranded structures composed of an RNA-DNA hybrid and a single strand of DNA. R-loops play critical roles in gene regulation and pathologic…”
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RNA Binding Proteins, Mechanisms Underlying Recognition of Targets by Biswas, Jeetayu

“…The fate of an RNA’s localization, translation and ultimate decay is dictated by interactions with RNA binding proteins (RBPs). Studies of RBPs have focused on…”
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GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies by Benbarche, Salima, Pineda, Jose Mario Bello, Galvis, Laura Baquero, Biswas, Jeetayu, Liu, Bo, Wang, Eric, Zhang, Qian, Hogg, Simon J, Lyttle, Kadeen, Dahi, Ariana, Lewis, Alexander M, Sarchi, Martina, Rahman, Jahan, Fox, Nina, Ai, Yuxi, Mehta, Sanjoy, Garippa, Ralph, Ortiz-Pacheco, Juliana, Li, Zhuoning, Monetti, Mara, Stanley, Robert F, Doulatov, Sergei, Bradley, Robert K, Abdel-Wahab, Omar

“…Mutations in the RNA splicing factor gene SF3B1 are common across hematologic and solid cancers and result in widespread alterations in splicing, yet there is…”
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Synthetic Introns Identify the Novel RNA Splicing Factor GPATCH8 As Required for Mis-Splicing Induced By SF3B1 Mutations by Benbarche, Salima, Pineda, Jose Maria Bello, Galvis, Laura Baquero, Liu, Bo, Biswas, Jeetayu, Wang, Eric, Lyttle, K. Ashley, Lewis, Alexander M., Sarchi, Martina, Mehta, Sanjoy, Garippa, Ralph, Ortiz-Pacheco, Juliana, Li, Zhuoning, Monetti, Mara, Stanley, Robert, Doulatov, Sergei, Bradley, Robert K., Abdel-Wahab, Omar

“…Mutations in the core RNA splicing factor SF3B1 are common across MDS, CLL, and clonal hematopoiesis. Prior studies have elucidated that mutations in SF3B1…”
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Zipcode Binding Protein 1 (ZBP1; IGF2BP1): A Model for Sequence-Specific RNA Regulation by Biswas, Jeetayu, Nunez, Leti, Das, Sulagna, Yoon, Young J, Eliscovich, Carolina, Singer, Robert H

“…The fate of an RNA, from its localization, translation, and ultimate decay, is dictated by interactions with RNA binding proteins (RBPs). β-actin mRNA has…”
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