Search Results - "Biswanath, Santoshi"
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Generation of heart-forming organoids from human pluripotent stem cells
Published in Nature protocols (01-12-2021)“…Heart-forming organoids (HFOs) derived from human pluripotent stem cells (hPSCs) are a complex, highly structured in vitro model of early heart, foregut and…”
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Human heart-forming organoids recapitulate early heart and foregut development
Published in Nature biotechnology (01-06-2021)“…Organoid models of early tissue development have been produced for the intestine, brain, kidney and other organs, but similar approaches for the heart have…”
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Femtosecond laser-based nanosurgery reveals the endogenous regeneration of single Z-discs including physiological consequences for cardiomyocytes
Published in Scientific reports (06-03-2019)“…A highly organized cytoskeleton architecture is the basis for continuous and controlled contraction in cardiomyocytes (CMs). Abnormalities in cytoskeletal…”
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Continuous WNT Control Enables Advanced hPSC Cardiac Processing and Prognostic Surface Marker Identification in Chemically Defined Suspension Culture
Published in Stem cell reports (13-08-2019)“…Aiming at clinical translation, robust directed differentiation of human pluripotent stem cells (hPSCs), preferentially in chemically defined conditions, is a…”
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Publisher Correction: Human heart-forming organoids recapitulate early heart and foregut development
Published in Nature biotechnology (01-06-2021)Get full text
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How Localized Z-Disc Damage Affects Force Generation and Gene Expression in Cardiomyocytes
Published in Bioengineering (Basel) (14-12-2021)“…The proper function of cardiomyocytes (CMs) is highly related to the Z-disc, which has a pivotal role in orchestrating the sarcomeric cytoskeletal function. To…”
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Myosin expression and contractile function are altered by replating stem cell-derived cardiomyocytes
Published in The Journal of general physiology (06-11-2023)“…Myosin heavy chain (MyHC) is the main determinant of contractile function. Human ventricular cardiomyocytes (CMs) predominantly express the β-isoform. We…”
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Replating of human pluripotent stem cell-derived cardiomyocytes alters myosin heavy chain expression and contractile parameters
Published in Biophysical journal (11-02-2022)Get full text
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