Search Results - "Bissonnette, John M."

A role for glia in the progression of Rett’s syndrome by Lioy, Daniel T., Garg, Saurabh K., Monaghan, Caitlin E., Raber, Jacob, Foust, Kevin D., Kaspar, Brian K., Hirrlinger, Petra G., Kirchhoff, Frank, Bissonnette, John M., Ballas, Nurit, Mandel, Gail

“…Astrocytes targeted in Rett's syndrome Rett's syndrome, a disorder caused by loss of function of methyl CpG-binding protein 2 (MeCP2), is associated with…”
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Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome by Garg, Saurabh K, Lioy, Daniel T, Cheval, Hélène, McGann, James C, Bissonnette, John M, Murtha, Matthew J, Foust, Kevin D, Kaspar, Brian K, Bird, Adrian, Mandel, Gail

“…De novo mutations in the X-linked gene encoding the transcription factor methyl-CpG binding protein 2 (MECP2) are the most frequent cause of the neurological…”
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Correction of respiratory disorders in a mouse model of Rett syndrome by Abdala, Ana P. L., Dutschmann, Mathias, Bissonnette, John M., Paton, Julian F. R., Mandel, Gail

“…Rett syndrome (RTT) is an autism spectrum disorder caused by mutations in the X-linked gene that encodes the transcription factor methyl-CpG-binding protein 2…”
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Deficiency of GABAergic synaptic inhibition in the Kölliker–Fuse area underlies respiratory dysrhythmia in a mouse model of Rett syndrome by Abdala, Ana Paula, Toward, Marie A., Dutschmann, Mathias, Bissonnette, John M., Paton, Julian F. R.

“…Key points Life threatening breathing irregularity and central apnoeas are highly prevalent in children suffering from Rett syndrome. Abnormalities in…”
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Pinpointing brainstem mechanisms responsible for autonomic dysfunction in Rett syndrome: therapeutic perspectives for 5-HT1A agonists by Abdala, Ana P, Bissonnette, John M, Newman-Tancredi, Adrian

“…Rett syndrome is a neurological disorder caused by loss of function of methyl-CpG-binding protein 2 (MeCP2). Reduced function of this ubiquitous…”
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μ opioid receptor activation hyperpolarizes respiratory‐controlling Kölliker–Fuse neurons and suppresses post‐inspiratory drive by Levitt, Erica S., Abdala, Ana P., Paton, Julian F. R., Bissonnette, John M., Williams, John T.

“…Key points In addition to reductions in respiratory rate, opioids also cause aspiration and difficulty swallowing, indicating impairment of the upper airways…”
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Respiration and Parturition Affected by Conditional Overexpression of the Ca2+-Activated K+Channel Subunit, SK3 by Bond, Chris T., Sprengel, Rolf, Bissonnette, John M., Kaufmann, Walter A., Pribnow, David, Neelands, Torben, Storck, Thorsten, Baetscher, Manfred, Jerecic, Jasna, Maylie, James, Knaus, Hans-Günther, Seeburg, Peter H., Adelman, John P.

“…In excitable cells, small-conductance Ca2+-activated potassium channels (SK channels) are responsible for the slow after-hyperpolarization that often follows…”
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Effect of positive allosteric modulation and orthosteric agonism of dopamine D2-like receptors on respiration in mouse models of Rett syndrome by Maletz, Sebastian N., Reid, Brandon T., Baekey, David M., Whitaker-Fornek, Jessica R., Bateman, Jordan T., Arakawa, Keiko, Bissonnette, John M., Levitt, Erica S.

“…Rett syndrome (RTT) is an autism spectrum disorder caused by loss-of-function mutations in the methyl-CPG-binding protein 2 (Mecp2) gene. Frequent apneas and…”
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Conditional depletion of methyl-CpG-binding protein 2 in astrocytes depresses the hypercapnic ventilatory response in mice by Garg, Saurabh K, Lioy, Daniel T, Knopp, Sharon J, Bissonnette, John M

“…Mice that are deficient in the transcription factor methyl-CpG-binding protein 2 (MeCP2) have a depressed hypercapnic ventilatory response (HCVR). The…”
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Effect of Sarizotan, a 5-HT1a and D2-like receptor agonist, on respiration in three mouse models of Rett syndrome by Abdala, Ana P, Lioy, Daniel T, Garg, Saurabh K, Knopp, Sharon J, Paton, Julian F R, Bissonnette, John M

“…Disturbances in respiration are common and debilitating features of Rett syndrome (RTT). A previous study showed that the 5-HT1a receptor agonist…”
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A selective 5-HT1a receptor agonist improves respiration in a mouse model of Rett syndrome by Levitt, Erica S, Hunnicutt, Barbara J, Knopp, Sharon J, Williams, John T, Bissonnette, John M

“…Rett syndrome is a neurological disorder caused by loss of function mutations in the gene that encodes the DNA binding protein methyl-CpG-binding protein 2…”
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Effect of inspired oxygen on periodic breathing in methy-CpG-binding protein 2 (Mecp2) deficient mice by Bissonnette, John M, Knopp, Sharon J

“…1 Department of Obstetrics and Gynecology and 2 Department of Cell and Development Biology, Oregon Health and Sciences University, Portland, Oregon Submitted 6…”
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Increasing brain serotonin corrects CO2 chemosensitivity in methyl‐CpG‐binding protein 2 (Mecp2)‐deficient mice by Toward, Marie A., Abdala, Ana P., Knopp, Sharon J., Paton, Julian F. R., Bissonnette, John M.

“…New Findings •  What is the central question of this study? Mice deficient in methyl‐CpG‐binding protein 2 (Mecp2; a model of Rett syndrome) display reduced…”
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Hypercapnic ventilatory response in mice lacking the 65 kDa isoform of Glutamic Acid Decarboxylase (GAD65) by Bissonnette, John M, Knopp, Sharon J

“…Recent reports have shown that there are developmental changes in the ventilatory response to hypercapnia in the rat. These are characterized by an initial…”
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Autonomic dysfunction with mutations in the gene that encodes methyl-CpG-binding protein 2: Insights into Rett syndrome by Lioy, Daniel T, Wu, Wendy W, Bissonnette, John M

“…Abstract Rett syndrome (RTT) is an autism spectrum disorder with an incidence of ~ 1:10,000 females (reviewed in Bird, 2008; Chahrour et al., 2007; Francke,…”
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Mechanisms regulating hypoxic respiratory depression during fetal and postnatal life by Bissonnette, J M

“…Selected topics in the respiratory response to acute hypoxia in the fetus and newborn are reviewed. Peripheral chemoreceptors acting through ionotrophic…”
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Separate respiratory phenotypes in methyl-CpG-binding protein 2 (Mecp2) deficient mice by BISSONNETTE, John M, KNOPP, Sharon J

“…Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the X-linked gene methyl-CpG-binding protein 2 (MECP2) that encodes a DNA binding…”
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Comment on the 100 most frequently cited ob-gyn journal articles in the last 50 years by Bissonnette, John M, Smith, Virginia J

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Autonomic cardiovascular control in methyl-CpG-binding protein 2 (Mecp2) deficient mice by Bissonnette, John M, Knopp, Sharon J, Maylie, James, Thong, Tran

“…Abstract Methyl-CpG-binding protein 2 is a transcription factor that is involved in gene silencing. It is mutated in the majority of cases of Rett syndrome…”
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Effect of hypoxia on expiratory muscle activity in fetal sheep by Bissonnette, John M, Hohimer, A. Roger, Knopp, Sharon J

“…Abstract The fetal respiratory response to acute hypoxia is characterized by depression, often to apnea. This study examined the effect of hypoxia on the…”
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