Intra-arterial cisplatin with or without radiation in limb-sparing for canine osteosarcoma

Forty-nine dogs with spontaneously occurring osteosarcoma underwent limb-sparing surgery after preoperative therapy consisting of intra-arterial cisplatin alone or intra-arterial cisplatin in combination with doses of radiation from 20-40 Gy in 10 fractions. All resections were marginal, and the def...

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Bibliographic Details
Published in:	Cancer Vol. 71; no. 8; p. 2484
Main Authors:	Withrow, S J, Thrall, D E, Straw, R C, Powers, B E, Wrigley, R H, Larue, S M, Page, R L, Richardson, D C, Bissonette, K W, Betts, C W
Format:	Journal Article
Language:	English
Published:	United States 15-04-1993
Subjects:	Amputation - veterinary Animals Bone Neoplasms - drug therapy Bone Neoplasms - radiotherapy Bone Neoplasms - veterinary Cisplatin - administration & dosage Combined Modality Therapy - veterinary Dogs Female Forelimb Humerus Injections, Intra-Arterial - veterinary Male Osteosarcoma - drug therapy Osteosarcoma - radiotherapy Osteosarcoma - veterinary Radiotherapy Dosage - veterinary Radius Rats Ulna
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Summary:	Forty-nine dogs with spontaneously occurring osteosarcoma underwent limb-sparing surgery after preoperative therapy consisting of intra-arterial cisplatin alone or intra-arterial cisplatin in combination with doses of radiation from 20-40 Gy in 10 fractions. All resections were marginal, and the defect was repaired with a cortical allograft. Local tumor control was strongly influenced by the percent necrosis in the excised specimen. Overall, the estimated 1-year local recurrence rate was approximately 32% (by life-table estimate). Dogs with less than 75% necrosis had an estimated 1-year recurrence rate of 65%; those with greater than 75% necrosis had an estimated 1-year recurrence rate of 15% (P = 0.004, by log-rank test). Local recurrence was influenced by the radiation dose. Dogs receiving 28 Gy or less had an estimated 50% 1-year recurrence rate, and those receiving 32 Gy or more had an estimated 8% 1-year recurrence rate (P = 0.03, by log-rank test). Normal host bone more frequently became necrotic at doses of 36 Gy or more. Intra-arterial cisplatin in combination with moderate doses of radiation (32 Gy) can achieve a high percent tumor necrosis while maintaining host bone viability. Survival was limited by distant metastasis but was lengthened by treatment compared with some earlier findings.
ISSN:	0008-543X
DOI:	10.1002/1097-0142(19930415)71:8<2484::AID-CNCR2820710810>3.0.CO;2-D