Search Results - "Bissler, John"

Everolimus long-term use in patients with tuberous sclerosis complex: Four-year update of the EXIST-2 study by Bissler, John J, Kingswood, J Chris, Radzikowska, Elzbieta, Zonnenberg, Bernard A, Belousova, Elena, Frost, Michael D, Sauter, Matthias, Brakemeier, Susanne, de Vries, Petrus J, Berkowitz, Noah, Voi, Maurizio, Peyrard, Severine, Budde, Klemens

“…We examined the long-term effects of everolimus in patients with renal angiomyolipoma associated with tuberous sclerosis complex or sporadic…”
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Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial by Bissler, John J, Prof, Kingswood, J Christopher, FRCP, Radzikowska, Elżbieta, MD, Zonnenberg, Bernard A, MD, Frost, Michael, MD, Belousova, Elena, Prof, Sauter, Matthias, MD, Nonomura, Norio, Prof, Brakemeier, Susanne, MD, de Vries, Petrus J, Prof, Whittemore, Vicky H, PhD, Chen, David, PhD, Sahmoud, Tarek, MD, Shah, Gaurav, MD, Lincy, Jeremie, MS, Lebwohl, David, MD, Budde, Klemens, Prof

“…Summary Background Angiomyolipomas are slow-growing tumours associated with constitutive activation of mammalian target of rapamycin (mTOR), and are common in…”
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Renal manifestation of tuberous sclerosis complex by Bissler, John J., Christopher Kingswood, J.

“…Tuberous sclerosis complex (TSC) is a tumor predisposition syndrome with significant renal cystic and solid tumor disease. It commonly causes several types of…”
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Renal cystic disease in tuberous sclerosis complex by Kumar, Prashant, Zadjali, Fahad, Yao, Ying, Bissler, John J

“…Tuberous sclerosis complex (TSC) is associated with TSC1 or TSC2 gene mutations resulting in hyperactivation of the mTORC1 pathway. This mTORC1 activation is…”
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Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management by McCormack, Francis X, Gupta, Nishant, Finlay, Geraldine R, Young, Lisa R, Taveira-DaSilva, Angelo M, Glasgow, Connie G, Steagall, Wendy K, Johnson, Simon R, Sahn, Steven A, Ryu, Jay H, Strange, Charlie, Seyama, Kuniaki, Sullivan, Eugene J, Kotloff, Robert M, Downey, Gregory P, Chapman, Jeffrey T, Han, MeiLan K, D'Armiento, Jeanine M, Inoue, Yoshikazu, Henske, Elizabeth P, Bissler, John J, Colby, Thomas V, Kinder, Brent W, Wikenheiser-Brokamp, Kathryn A, Brown, Kevin K, Cordier, Jean F, Meyer, Cristopher, Cottin, Vincent, Brozek, Jan L, Smith, Karen, Wilson, Kevin C, Moss, Joel

“…Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease that primarily affects women. The purpose of these guidelines is to provide recommendations for…”
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Early therapy with sirolimus reduces size of a large solid renal mass but not seizure activity in an infant with tuberous sclerosis by Hani, Salar Bani, Artunduaga, Maddy, Ludwig, Kathleen, Bissler, John J., Wolf, Matthias T. F.

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Angiomyolipoma rebound tumor growth after discontinuation of everolimus in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis by Bissler, John J, Nonomura, Norio, Budde, Klemens, Zonnenberg, Bernard A, Fischereder, Michael, Voi, Maurizio, Louveau, Anne-Laure, Herbst, Fabian, Bebin, E Martina, Curatolo, Paolo, Zonta, Andrea, Belousova, Elena

“…The EXIST-2 (NCT00790400) study demonstrated the superiority of everolimus over placebo for the treatment of renal angiomyolipomas associated with tuberous…”
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Lymphangioleiomyomatosis Screening in Women With Tuberous Sclerosis by Cudzilo, Corey J., MD, Szczesniak, Rhonda D., PhD, Brody, Alan S., MD, Rattan, Mantosh S., MD, Krueger, Darcy A., MD, PhD, Bissler, John J., MD, Franz, David N., MD, McCormack, Francis X., MD, FCCP, Young, Lisa R., MD

“…Background Lymphangioleiomyomatosis (LAM) occurs in at least 40% of women with tuberous sclerosis complex (TSC), as diagnosed based on chest CT scan findings…”
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Everolimus for renal angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis: extension of a randomized controlled trial by Bissler, John J, Kingswood, John Christopher, Radzikowska, Elżbieta, Zonnenberg, Bernard A, Frost, Michael, Belousova, Elena, Sauter, Matthias, Nonomura, Norio, Brakemeier, Susanne, de Vries, Petrus J, Berkowitz, Noah, Miao, Sara, Segal, Scott, Peyrard, Severine, Budde, Klemens

“…Mammalian target of rapamycin (mTOR) inhibitors are recommended as first-line treatment of renal angiomyolipoma associated with tuberous sclerosis complex…”
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Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex by Barone, Sharon, Zahedi, Kamyar, Brooks, Marybeth, Henske, Elizabeth P., Yang, Yirong, Zhang, Erik, Bissler, John J., Yu, Jane J., Soleimani, Manoocher

“…Tuberous sclerosis complex (TSC) is caused by mutations in either TSC1 or TSC2 genes and affects multiple organs, including kidney, lung, and brain. In the…”
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Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis by Bissler, John J, McCormack, Francis X, Young, Lisa R, Elwing, Jean M, Chuck, Gail, Leonard, Jennifer M, Schmithorst, Vincent J, Laor, Tal, Brody, Alan S, Bean, Judy, Salisbury, Shelia, Franz, David N

“…In this open-label trial, patients with tuberous sclerosis or lymphangioleiomyomatosis — conditions with constitutive activation of signaling by the mammalian…”
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Physiologically Based Pharmacokinetic Modeling of Extracellular Vesicles by Kumar, Prashant, Mehta, Darshan, Bissler, John J

“…Extracellular vesicles (EVs) are lipid membrane bound-cell-derived structures that are a key player in intercellular communication and facilitate numerous…”
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Replication-dependent instability at (CTG)•(CAG) repeat hairpins in human cells by Leffak, Michael, Liu, Guoqi, Chen, Xiaomi, Bissler, John J, Sinden, Richard R

“…Instability of (CTG)•(CAG) repeats in microsatellite DNA has been linked to numerous neurological diseases. Probing trinucleotide repeat structures using…”
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Tuberous sclerosis complex renal disease by Dixon, Bradley P, Hulbert, John C, Bissler, John J

“…Although not as common as other genetic renal diseases such as autosomal dominant polycystic kidney disease, patients with tuberous sclerosis complex…”
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Consensus Expert Recommendations for the Diagnosis and Management of Autosomal Recessive Polycystic Kidney Disease: Report of an International Conference by Guay-Woodford, Lisa M., MD, Bissler, John J., MD, Braun, Michael C., MD, Bockenhauer, Detlef, MD, Cadnapaphornchai, Melissa A., MD, Dell, Katherine M., MD, Kerecuk, Larissa, MD, Liebau, Max C., MD, Alonso-Peclet, Maria H., MD, Shneider, Benjamin, MD, Emre, Sukru, MD, Heller, Theo, MD, Kamath, Binita M., MD, Murray, Karen F., MD, Moise, Kenneth, MD, Eichenwald, Eric E., MD, Evans, Jacquelyn, MD, Keller, Roberta L., MD, Wilkins-Haug, Louise, MD, Bergmann, Carsten, MD, Gunay-Aygun, Meral, MD, Hooper, Stephen R., PhD, Hardy, Kristina K., PhD, Hartung, Erum A., MD, Streisand, Randi, PhD, Perrone, Ronald, MD, Moxey-Mims, Marva, MD

“…Autosomal recessive polycystic kidney disease (ARPKD; MIM 263200) is a severe, typically early onset form of cystic disease that primarily involves the kidneys…”
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Pooled analysis of menstrual irregularities from three major clinical studies evaluating everolimus for the treatment of tuberous sclerosis complex by Sparagana, Steven, Franz, David N, Krueger, Darcy A, Bissler, John J, Berkowitz, Noah, Burock, Karin, Kingswood, J Christopher

“…To determine the impact of everolimus on female fertility, including menstrual irregularities, secondary amenorrhea, and luteinizing and follicle stimulating…”
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Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases by Young, Lisa R, Vandyke, Rhonda, Gulleman, Peter M, Inoue, Yoshikazu, Brown, Kevin K, Schmidt, Laura S, Linehan, W Marston, Hajjar, Fuad, Kinder, Brent W, Trapnell, Bruce C, Bissler, John J, Franz, David N, McCormack, Francis X

“…The majority of women with lymphangioleiomyomatosis (LAM) present with cystic lung disease, and most require lung biopsy for definitive diagnosis. The purpose…”
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Indocyanine green–guided nephron-sparing surgery for pediatric renal tumors by Abdelhafeez, Abdelhafeez H., Murphy, Andrew J., Brennan, Rachel, Santiago, Teresa C., Lu, Zhaohua, Krasin, Matthew J., Bissler, John J., Gleason, Joseph M., Davidoff, Andrew M.

“…Indocyanine green (ICG), a water-soluble tricarbocyanine fluorophore, is being increasingly used for tumor localization based on its passive intra-tumoral…”
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Effect of everolimus on renal function in patients with tuberous sclerosis complex: evidence from EXIST-1 and EXIST-2 by Bissler, John J, Budde, Klemens, Sauter, Matthias, Franz, David N, Zonnenberg, Bernard A, Frost, Michael D, Belousova, Elena, Berkowitz, Noah, Ridolfi, Antonia, Christopher Kingswood, J

“…Abstract Background A reduction in renal angiomyolipoma volume observed with everolimus (EVE) treatment in patients with tuberous sclerosis complex (TSC) has…”
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A step-wise approach for establishing a multidisciplinary team for the management of tuberous sclerosis complex: a Delphi consensus report by Auvin, Stéphane, Bissler, John J, Cottin, Vincent, Fujimoto, Ayataka, Hofbauer, Günther F L, Jansen, Anna C, Jóźwiak, Sergiusz, Kerecuk, Larissa, Kingswood, J Christopher, Moavero, Romina, Torra, Roser, Villanueva, Vicente

“…Tuberous sclerosis complex (TSC) is a rare autosomal dominant genetic disorder associated with mutations in TSC1 and TSC2 genes, upregulation of mammalian…”
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