Search Results - "Bissler, J. J."

Renal manifestation of tuberous sclerosis complex by Bissler, John J., Christopher Kingswood, J.

“…Tuberous sclerosis complex (TSC) is a tumor predisposition syndrome with significant renal cystic and solid tumor disease. It commonly causes several types of…”
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Everolimus long-term use in patients with tuberous sclerosis complex: Four-year update of the EXIST-2 study by Bissler, John J, Kingswood, J Chris, Radzikowska, Elzbieta, Zonnenberg, Bernard A, Belousova, Elena, Frost, Michael D, Sauter, Matthias, Brakemeier, Susanne, de Vries, Petrus J, Berkowitz, Noah, Voi, Maurizio, Peyrard, Severine, Budde, Klemens

“…We examined the long-term effects of everolimus in patients with renal angiomyolipoma associated with tuberous sclerosis complex or sporadic…”
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Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management by McCormack, Francis X, Gupta, Nishant, Finlay, Geraldine R, Young, Lisa R, Taveira-DaSilva, Angelo M, Glasgow, Connie G, Steagall, Wendy K, Johnson, Simon R, Sahn, Steven A, Ryu, Jay H, Strange, Charlie, Seyama, Kuniaki, Sullivan, Eugene J, Kotloff, Robert M, Downey, Gregory P, Chapman, Jeffrey T, Han, MeiLan K, D'Armiento, Jeanine M, Inoue, Yoshikazu, Henske, Elizabeth P, Bissler, John J, Colby, Thomas V, Kinder, Brent W, Wikenheiser-Brokamp, Kathryn A, Brown, Kevin K, Cordier, Jean F, Meyer, Cristopher, Cottin, Vincent, Brozek, Jan L, Smith, Karen, Wilson, Kevin C, Moss, Joel

“…Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease that primarily affects women. The purpose of these guidelines is to provide recommendations for…”
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Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial by Bissler, John J, Prof, Kingswood, J Christopher, FRCP, Radzikowska, Elżbieta, MD, Zonnenberg, Bernard A, MD, Frost, Michael, MD, Belousova, Elena, Prof, Sauter, Matthias, MD, Nonomura, Norio, Prof, Brakemeier, Susanne, MD, de Vries, Petrus J, Prof, Whittemore, Vicky H, PhD, Chen, David, PhD, Sahmoud, Tarek, MD, Shah, Gaurav, MD, Lincy, Jeremie, MS, Lebwohl, David, MD, Budde, Klemens, Prof

“…Summary Background Angiomyolipomas are slow-growing tumours associated with constitutive activation of mammalian target of rapamycin (mTOR), and are common in…”
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Tuberous sclerosis complex: neurological, renal and pulmonary manifestations by Franz, D N, Bissler, J J, McCormack, F X

“…Tuberous sclerosis complex (TSC) is an important cause of epilepsy and autism, as well as renal and pulmonary disease in adults and children. Affected…”
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Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex by Barone, Sharon, Zahedi, Kamyar, Brooks, Marybeth, Henske, Elizabeth P., Yang, Yirong, Zhang, Erik, Bissler, John J., Yu, Jane J., Soleimani, Manoocher

“…Tuberous sclerosis complex (TSC) is caused by mutations in either TSC1 or TSC2 genes and affects multiple organs, including kidney, lung, and brain. In the…”
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Physiologically Based Pharmacokinetic Modeling of Extracellular Vesicles by Kumar, Prashant, Mehta, Darshan, Bissler, John J

“…Extracellular vesicles (EVs) are lipid membrane bound-cell-derived structures that are a key player in intercellular communication and facilitate numerous…”
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Tuberous sclerosis complex renal disease by Dixon, Bradley P, Hulbert, John C, Bissler, John J

“…Although not as common as other genetic renal diseases such as autosomal dominant polycystic kidney disease, patients with tuberous sclerosis complex…”
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Consensus Expert Recommendations for the Diagnosis and Management of Autosomal Recessive Polycystic Kidney Disease: Report of an International Conference by Guay-Woodford, Lisa M., MD, Bissler, John J., MD, Braun, Michael C., MD, Bockenhauer, Detlef, MD, Cadnapaphornchai, Melissa A., MD, Dell, Katherine M., MD, Kerecuk, Larissa, MD, Liebau, Max C., MD, Alonso-Peclet, Maria H., MD, Shneider, Benjamin, MD, Emre, Sukru, MD, Heller, Theo, MD, Kamath, Binita M., MD, Murray, Karen F., MD, Moise, Kenneth, MD, Eichenwald, Eric E., MD, Evans, Jacquelyn, MD, Keller, Roberta L., MD, Wilkins-Haug, Louise, MD, Bergmann, Carsten, MD, Gunay-Aygun, Meral, MD, Hooper, Stephen R., PhD, Hardy, Kristina K., PhD, Hartung, Erum A., MD, Streisand, Randi, PhD, Perrone, Ronald, MD, Moxey-Mims, Marva, MD

“…Autosomal recessive polycystic kidney disease (ARPKD; MIM 263200) is a severe, typically early onset form of cystic disease that primarily involves the kidneys…”
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Renal angiomyolipomata by Bissler, John J., Kingswood, J. Chris

“…Renal angiomyolipomata. Renal angiomyolipomata can exist as an imaging curiosity or represent a life-threatening condition. There are likely over 10 million…”
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Angiomyolipoma rebound tumor growth after discontinuation of everolimus in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis by Bissler, John J, Nonomura, Norio, Budde, Klemens, Zonnenberg, Bernard A, Fischereder, Michael, Voi, Maurizio, Louveau, Anne-Laure, Herbst, Fabian, Bebin, E Martina, Curatolo, Paolo, Zonta, Andrea, Belousova, Elena

“…The EXIST-2 (NCT00790400) study demonstrated the superiority of everolimus over placebo for the treatment of renal angiomyolipomas associated with tuberous…”
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Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases by Young, Lisa R, Vandyke, Rhonda, Gulleman, Peter M, Inoue, Yoshikazu, Brown, Kevin K, Schmidt, Laura S, Linehan, W Marston, Hajjar, Fuad, Kinder, Brent W, Trapnell, Bruce C, Bissler, John J, Franz, David N, McCormack, Francis X

“…The majority of women with lymphangioleiomyomatosis (LAM) present with cystic lung disease, and most require lung biopsy for definitive diagnosis. The purpose…”
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A step-wise approach for establishing a multidisciplinary team for the management of tuberous sclerosis complex: a Delphi consensus report by Auvin, Stéphane, Bissler, John J, Cottin, Vincent, Fujimoto, Ayataka, Hofbauer, Günther F L, Jansen, Anna C, Jóźwiak, Sergiusz, Kerecuk, Larissa, Kingswood, J Christopher, Moavero, Romina, Torra, Roser, Villanueva, Vicente

“…Tuberous sclerosis complex (TSC) is a rare autosomal dominant genetic disorder associated with mutations in TSC1 and TSC2 genes, upregulation of mammalian…”
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Lymphangioleiomyomatosis Screening in Women With Tuberous Sclerosis by Cudzilo, Corey J., MD, Szczesniak, Rhonda D., PhD, Brody, Alan S., MD, Rattan, Mantosh S., MD, Krueger, Darcy A., MD, PhD, Bissler, John J., MD, Franz, David N., MD, McCormack, Francis X., MD, FCCP, Young, Lisa R., MD

“…Background Lymphangioleiomyomatosis (LAM) occurs in at least 40% of women with tuberous sclerosis complex (TSC), as diagnosed based on chest CT scan findings…”
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Tuberous Sclerosis Complex and the kidneys: what nephrologists need to know by Monich, Aline Grosskopf, Bissler, John J, Barreto, Fellype Carvalho

“…Tuberous sclerosis complex (TSC) is an autosomal dominant disease characterized by the development of hamartomas in the central nervous system, heart, skin,…”
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Tuberous Sclerosis Complex Axis Controls Renal Extracellular Vesicle Production and Protein Content by Zadjali, Fahad, Kumar, Prashant, Yao, Ying, Johnson, Daniel, Astrinidis, Aristotelis, Vogel, Peter, Gross, Kenneth W, Bissler, John J

“…The tuberous sclerosis complex (Tsc) proteins regulate the conserved mTORC1 growth regulation pathway. We identified that loss of the gene in mouse inner…”
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Tsc Gene Locus Disruption and Differences in Renal Epithelial Extracellular Vesicles by Kumar, Prashant, Zadjali, Fahad, Yao, Ying, Siroky, Brian, Astrinidis, Aristotelis, Gross, Kenneth W., Bissler, John J.

“…In tuberous sclerosis complex (TSC), Tsc2 mutations are associated with more severe disease manifestations than Tsc1 mutations and the role of extracellular…”
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Review of the Tuberous Sclerosis Renal Guidelines from the 2012 Consensus Conference: Current Data and Future Study by Kingswood, J Chris, Bissler, John J, Budde, Klemens, Hulbert, John, Guay-Woodford, Lisa, Sampson, Julian R, Sauter, Matthias, Cox, Jane, Patel, Uday, Elmslie, Frances, Anderson, Chris, Zonnenberg, Bernard A

“…Renal-related disease is the most common cause of tuberous sclerosis complex (TSC)-related death in adults, and renal angiomyolipomas can lead to complications…”
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The effect of everolimus on renal angiomyolipoma in patients with tuberous sclerosis complex being treated for subependymal giant cell astrocytoma: subgroup results from the randomized, placebo-controlled, Phase 3 trial EXIST-1 by Kingswood, J Chris, Jozwiak, Sergiusz, Belousova, Elena D, Frost, Michael D, Kuperman, Rachel A, Bebin, E Martina, Korf, Bruce R, Flamini, J Robert, Kohrman, Michael H, Sparagana, Steven P, Wu, Joyce Y, Brechenmacher, Thomas, Stein, Karen, Berkowitz, Noah, Bissler, John J, Franz, David N

“…Tuberous sclerosis complex (TSC) is characterized by benign tumours in multiple organs, including the brain, kidneys, skin, lungs and heart. Our objective was…”
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Effect of everolimus on skin lesions in patients treated for subependymal giant cell astrocytoma and renal angiomyolipoma: final 4‐year results from the randomized EXIST‐1 and EXIST‐2 studies by Franz, D.N., Budde, K., Kingswood, J.C., Belousova, E., Sparagana, S., Vries, P.J., Berkowitz, N., Ridolfi, A., Bissler, J.J.

“…Background Tuberous sclerosis complex (TSC) is a genetic disorder associated with tumour growth in various organs, including the brain, kidneys, heart and…”
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