Search Results - "Bishoy, Hanna"

NUDT22 promotes cancer growth through pyrimidine salvage by Walter, Melanie, Mayr, Florian, Hanna, Bishoy M. F., Cookson, Victoria, Mortusewicz, Oliver, Helleday, Thomas, Herr, Patrick

“…The NUDIX hydrolase NUDT22 converts UDP-glucose into glucose-1-phosphate and the pyrimidine nucleotide uridine monophosphate but a biological significance for…”
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Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation by Visnes, Torkild, Cázares-Körner, Armando, Hao, Wenjing, Wallner, Olov, Masuyer, Geoffrey, Loseva, Olga, Mortusewicz, Oliver, Wiita, Elisée, Sarno, Antonio, Manoilov, Aleksandr, Astorga-Wells, Juan, Jemth, Ann-Sofie, Pan, Lang, Sanjiv, Kumar, Karsten, Stella, Gokturk, Camilla, Grube, Maurice, Homan, Evert J, Hanna, Bishoy M F, Paulin, Cynthia B J, Pham, Therese, Rasti, Azita, Berglund, Ulrika Warpman, von Nicolai, Catharina, Benitez-Buelga, Carlos, Koolmeister, Tobias, Ivanic, Dag, Iliev, Petar, Scobie, Martin, Krokan, Hans E, Baranczewski, Pawel, Artursson, Per, Altun, Mikael, Jensen, Annika Jenmalm, Kalderén, Christina, Ba, Xueqing, Zubarev, Roman A, Stenmark, Pål, Boldogh, Istvan, Helleday, Thomas

“…The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA…”
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Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects by Baquero, Juan Miguel, Benítez-Buelga, Carlos, Rajagopal, Varshni, Zhenjun, Zhao, Torres-Ruiz, Raúl, Müller, Sarah, Hanna, Bishoy M. F., Loseva, Olga, Wallner, Olov, Michel, Maurice, Rodríguez-Perales, Sandra, Gad, Helge, Visnes, Torkild, Helleday, Thomas, Benítez, Javier, Osorio, Ana

“…The most common oxidative DNA lesion is 8-oxoguanine which is mainly recognized and excised by the 8-oxoG DNA glycosylase 1 (OGG1), initiating the base…”
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NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487 by Hanna, Bishoy M F, Michel, Maurice, Helleday, Thomas, Mortusewicz, Oliver

“…DNA damage caused by reactive oxygen species may result in genetic mutations or cell death. Base excision repair (BER) is the major pathway that repairs DNA…”
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The therapeutic role of interleukin-10 after spinal cord injury by Thompson, Colton D, Zurko, Joanna C, Hanna, Bishoy F, Hellenbrand, Daniel J, Hanna, Amgad

“…Spinal cord injury (SCI) is a devastating condition affecting 270,000 people in the United States. A potential treatment for decreasing the secondary…”
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OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions by Hanna, Bishoy M F, Helleday, Thomas, Mortusewicz, Oliver

“…8-oxoguanine DNA glycosylase (OGG1) is the main DNA glycosylase responsible for the excision of 7,8-dihydro-8-oxoguanine (8-oxoG) from duplex DNA to initiate…”
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The Effects of Glial Cell Line-Derived Neurotrophic Factor after Spinal Cord Injury by Rosich, Konstantin, Hanna, Bishoy F, Ibrahim, Rami K, Hellenbrand, Daniel J, Hanna, Amgad

“…Spinal cord injury (SCI) is a devastating condition affecting 270,000 people in the United States. The use of growth factors is a potential treatment for…”
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Empty Niches after Extinctions Increase Population Sizes of Modern Corals by Prada, Carlos, Hanna, Bishoy, Budd, Ann F., Woodley, Cheryl M., Schmutz, Jeremy, Grimwood, Jane, Iglesias-Prieto, Roberto, Pandolfi, John M., Levitan, Don, Johnson, Kenneth G., Knowlton, Nancy, Kitano, Hiroaki, DeGiorgio, Michael, Medina, Mónica

“…Large environmental fluctuations often cause mass extinctions, extirpating species and transforming communities [1, 2]. While the effects on community…”
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Near-future pH conditions severely impact calcification, metabolism and the nervous system in the pteropod Heliconoides inflatus by Moya, Aurelie, Howes, Ella L., Lacoue-Labarthe, Thomas, Forêt, Sylvain, Hanna, Bishoy, Medina, Mónica, Munday, Philip L., Ong, Jue-Sheng, Teyssié, Jean-Louis, Torda, Gergely, Watson, Sue-Ann, Miller, David J., Bijma, Jelle, Gattuso, Jean-Pierre

“…Shelled pteropods play key roles in the global carbon cycle and food webs of various ecosystems. Their thin external shell is sensitive to small changes in pH,…”
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Targeting OGG1 arrests cancer cell proliferation by inducing replication stress by Visnes, Torkild, Benítez-Buelga, Carlos, Cázares-Körner, Armando, Sanjiv, Kumar, Hanna, Bishoy M F, Mortusewicz, Oliver, Rajagopal, Varshni, Albers, Julian J, Hagey, Daniel W, Bekkhus, Tove, Eshtad, Saeed, Baquero, Juan Miguel, Masuyer, Geoffrey, Wallner, Olov, Müller, Sarah, Pham, Therese, Göktürk, Camilla, Rasti, Azita, Suman, Sharda, Torres-Ruiz, Raúl, Sarno, Antonio, Wiita, Elisée, Homan, Evert J, Karsten, Stella, Marimuthu, Karthick, Michel, Maurice, Koolmeister, Tobias, Scobie, Martin, Loseva, Olga, Almlöf, Ingrid, Unterlass, Judith Edda, Pettke, Aleksandra, Boström, Johan, Pandey, Monica, Gad, Helge, Herr, Patrick, Jemth, Ann-Sofie, El Andaloussi, Samir, Kalderén, Christina, Rodriguez-Perales, Sandra, Benítez, Javier, Krokan, Hans E, Altun, Mikael, Stenmark, Pål, Berglund, Ulrika Warpman, Helleday, Thomas

“…Abstract Altered oncogene expression in cancer cells causes loss of redox homeostasis resulting in oxidative DNA damage, e.g. 8-oxoguanine (8-oxoG), repaired…”
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BET inhibitor trotabresib in heavily pretreated patients with solid tumors and diffuse large B-cell lymphomas by Moreno, Victor, Vieito, Maria, Sepulveda, Juan Manuel, Galvao, Vladimir, Hernández-Guerrero, Tatiana, Doger, Bernard, Saavedra, Omar, Carlo-Stella, Carmelo, Michot, Jean-Marie, Italiano, Antoine, Magagnoli, Massimo, Carpio, Cecilia, Pinto, Antonio, Sarmiento, Rafael, Amoroso, Barbara, Aronchik, Ida, Filvaroff, Ellen, Hanna, Bishoy, Wei, Xin, Nikolova, Zariana, Braña, Irene

“…Bromodomain and extraterminal proteins (BET) play key roles in regulation of gene expression, and may play a role in cancer-cell proliferation, survival, and…”
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EKG AS A NON-FUNGIBLE TOKEN (NFT): A SCHEMA FOR STORING HEALTHCARE DATA ON THE PUBLIC BLOCKCHAIN by Hanna, Bishoy, Chatterjee, Neal A., Akoum, Nazem

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Urology Amidst the War on COVID-19 by Hanna, Bishoy, Jackson, Stuart, Narroway, Harry, Chung, Amanda

“…Objectives: We sought to review the impact of the COVID-19 pandemic on the practice of urology internationally, with particular focus on the Australian…”
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Sickle cell disease‐associated arrhythmias and in‐hospital outcomes: Insights from the National Inpatient Sample by Patel, Upenkumar, Desai, Rupak, Hanna, Bishoy, Patel, Dhruval, Akbar, Shahzad, Zubair, Mohammed, Kumar, Gautam, Sachdeva, Rajesh

“…Background The frequency and temporal trend in the prevalence of arrhythmias and associated in‐hospital outcomes in patients with sickle cell disease (SCD)…”
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Robotic repair of indirect inguinoscrotal bladder hernia by Pham, Cecile T, Hanna, Bishoy, Samra, Jaswinder, Winter, Matthew

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Urethral caruncle with intestinal metaplasia: A case report and literature review by Hanna, Bishoy, Hanna, Amir, Wines, Michael

“…A 66-year-old female presented with a urethral caruncle. Histological features of incomplete intestinal metaplasia were reported. Only five previous cases of…”
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Prognostic value of tumor‑infiltrating lymphocytes in estrogen receptor‑positive and human epidermal growth factor receptor 2‑negative breast cancer by Honda, Chikako, Kurozumi, Sasagu, Katayama, Ayaka, Hanna-Khalil, Bishoy, Masuda, Kei, Nakazawa, Yuko, Ogino, Misato, Obayashi, Sayaka, Yajima, Reina, Makiguchi, Takaya, Oyama, Tetsunari, Horiguchi, Jun, Shirabe, Ken, Fujii, Takaaki

“…Tumor-infiltrating lymphocytes (TILs) are a significant prognostic factor in triple-negative breast cancer. However, the clinicopathological significance of…”
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Double partial nephrectomy in allograft transplanted kidney by Hanna, Bishoy, White, Jared, Chalasani, Venu, McGinn, Stella, Winter, Matthew

“…A 61-year-old female presented with an incidental anterior mid pole renal mass on ultrasound. She had previously undergone live directed donor renal…”
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Contemporary Pharmacologic Management of Heart Failure with Reduced Ejection Fraction: A Review by Egbuche, Obiora, Hanna, Bishoy, Onuorah, Ifeoma, Uko, Emmanuela, Taha, Yasir, Ghali, Jalal K, Onwuanyi, Anekwe

“…Heart failure with reduced ejection fraction (HFrEF) is defined as the presence of typical symptoms of heart failure (HF) and a left ventricular ejection…”
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A Review of the Potential Health Benefits of Low Alcohol and Alcohol-Free Beer: Effects of Ingredients and Craft Brewing Processes on Potentially Bioactive Metabolites by Mellor, Duane D., Hanna-Khalil, Bishoy, Carson, Raymond

“…Beer is a beverage of significant historical and cultural importance. Interest in the potential health effects of alcoholic beverages has largely focused on…”
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