Search Results - "Bishara, Daniel"

Development of a derivatization RP-HPLC method for determination of sulfuryl chloride in chlorosulfonic acid for gefapixant citrate manufacture by Huang, Chunli, Song, Siqing, Liu, Wenjun, Parganiha, Priya, Zhuang, Ping, Lohani, Sachin, Alwedi, Embarek, Ren, Hong, Bishara, Daniel, Chang, Hsieh Yao D.

“…Control of process impurities during manufacturing of drug substance is critical to ensure quality and process robustness. During commercial process…”
Get full text

Integrating Process Development and Safety Analysis for Scale-Up of a Diborane-Generating Reduction Reaction by Armstrong, Brittany M., Behre, Taylor, Turnbull, Ben W. H., Bishara, Daniel, Hartmanshenn, Clara, McCarthy, Erin, Whittington, Michael, Ji, Yining, Jenks, Anna, Desmond, Richard, Muzzio, Daniel J., Corry, James, Zhao, Ralph, Kuhl, Nadine, Chung, Cheol K.

“…Our company has developed a robust and scalable process to synthesize an amino alcohol tosylate salt, a penultimate intermediate in the synthesis of…”
Get full text

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 2: Development of a Robust Process for Phenol Synthesis by Peng, Feng, Humphrey, Guy R, Maloney, Kevin M, Lehnherr, Dan, Weisel, Mark, Lévesque, Francois, Naber, John R, Brunskill, Andrew P. J, Larpent, Patrick, Zhang, Si-Wei, Lee, Alfred Y, Arvary, Rebecca A, Lee, Claire H, Bishara, Daniel, Narsimhan, Karthik, Sirota, Eric, Whittington, Michael

“…Various synthetic routes to 2-isopropyl-4-methoxyphenol 3, the phenol core of Gefapixant citrate (MK-7264), are described, which provide better alternatives to…”
Get full text